Protein Alignment Adgf-D and AMPD1

DIOPT Version :9

• Sequence 1: NP_524345.2
• Gene: Adgf-D / 41679
• FlyBaseID: FBgn0038172
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_000027.3
• Gene: AMPD1 / 270
• HGNCID: 468
• Length: 747
• Species: Homo sapiens
• Alignment Length: 544
• Identity: 110/544 - (20%)
• Similarity: 186/544 - (34%)
• Gaps: 179/544 - (32%)

  Fly    49 LSSDEEK------ANSIL--MNAKRAEIAEG-LKTPE----KYAPAMHFFQGRQYVRQSEVFRMI 100
            :|.||.|      .::.|  ||...|.||:| :||..    |:..:.  ||..|.:.:.:..:.:
Human   224 VSKDEPKPLPYPNLDTFLDDMNFLLALIAQGPVKTYTHRRLKFLSSK--FQVHQMLNEMDELKEL 286

  Fly   101 QKIPKGAFLHGHNTGMVTSRWIIQNLTTTNNLYTCRNVDGLLVFTYDQSGCHSEVQ--------- 156
            :..|...|                        |.||.||..:    ..:.|.::..
Human   287 KNNPHRDF------------------------YNCRKVDTHI----HAAACMNQKHLLRFIKKSY 323

  Fly   157 NVCTERI--NAEDRGKYERQLEKHINMHGPRPEALLPNR------KKIWERFENIFTTVDRLYKY 213
            .:..:|:  :.:::....::|...:.||   |..|..:.      ::.::||:....      ||
Human   324 QIDADRVVYSTKEKNLTLKELFAKLKMH---PYDLTVDSLDVHAGRQTFQRFDKFND------KY 379

  Fly   214 RPT--------------------YCAYHKRMLEELCEDNIIYAEIRASLSPLYDDNNRTLSTLEV 258
            .|.                    :....|.:..:|.|....:||.|.|:.....|....||:..|
Human   380 NPVGASELRDLYLKTDNYINGEYFATIIKEVGADLVEAKYQHAEPRLSIYGRSPDEWSKLSSWFV 444

  Fly   259 AN-----------ELERIVEEFKAKHH--------DFIGVKVIYAKRNRASEEEM---LRRITTF 301
            .|           ::.||.:.|::|:.        :.|.:.|..|..|..::.|:   |:.||.|
Human   445 CNRIHCPNMTWMIQVPRIYDVFRSKNFLPHFGKMLENIFMPVFEATINPQADPELSVFLKHITGF 509

  Fly   302 -------KQLHH------AKPNFVIGFDLIGQEDTGEPLNRY-------------INQLSDLPST 340
                   |...|      .||          ||.|.|....|             :|.|......
Human   510 DSVDDESKHSGHMFSSKSPKP----------QEWTLEKNPSYTYYAYYMYANIMVLNSLRKERGM 564

  Fly   341 ANYFF--HAGETNWNGRTDWNMMDAILLNTKRIGHAFALPKHPQLWSTIKKRNIAIEVNPISNQV 403
            ..:.|  |.||..    ...::|.|.:: ...|.|...|.|.|.|........|.|.::|:||..
Human   565 NTFLFRPHCGEAG----ALTHLMTAFMI-ADDISHGLNLKKSPVLQYLFFLAQIPIAMSPLSNNS 624

  Fly   404 LGFVWDLRNHPASFLIAENFPIVISSDDPGVWGAKGLSYDF-------YYAFMA----LAPADAD 457
            | |:...:|....|| .:...|.:|:|||       :.:.|       .||..|    |:..|
Human   625 L-FLEYAKNPFLDFL-QKGLMISLSTDDP-------MQFHFTKEPLMEEYAIAAQVFKLSTCD-- 678

  Fly   458 LRFLKQLALNSIKYAVLTSDERRK 481
               :.::|.||:....::.:|:.|
Human   679 ---MCEVARNSVLQCGISHEEKVK 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-D	NP_524345.2	A_deaminase_N	4..100	CDD:285627	17/63 (27%)
		adm_rel	27..498	CDD:273620	110/544 (20%)
		ADGF	80..490	CDD:238646	96/500 (19%)
AMPD1	NP_000027.3	AMPD	240..736	CDD:238644	106/528 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810