DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adgf-D and Ada

DIOPT Version :9

Sequence 1:	NP_524345.2	Gene:	Adgf-D / 41679	FlyBaseID:	FBgn0038172	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001258981.1	Gene:	Ada / 11486	MGIID:	87916	Length:	352	Species:	Mus musculus

Alignment Length:	379	Identity:	80/379 - (21%)
Similarity:	146/379 - (38%)	Gaps:	98/379 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 QLEKHINMHGP-RPEALLPNRKK--------IWERFENIFTTVDR-------LYK---YRPTYCA 219
            ::|.|:::.|. :||.:|...||        ..|...||. .:|:       |.|   |.|....
Mouse    11 KVELHVHLDGAIKPETILYFGKKRGIALPADTVEELRNII-GMDKPLSLPGFLAKFDYYMPVIAG 74

  Fly   220 YH---KRMLEELCE----DNIIYAEIRASLSPLYDDN------NRTLSTLEVANELERIVEEFKA 271
            ..   ||:..|..|    :.::|.|:|.|...|.:..      |:|...: ..:::..:|.:...
Mouse    75 CREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVDPMPWNQTEGDV-TPDDVVDLVNQGLQ 138

  Fly   272 KHHDFIGVKV---IYAKRNRAS-EEEMLRRITTFKQLHHAKPNFVIGFDLIGQEDTGEPLNRYIN 332
            :.....|:||   :...|::.| ..|:|.....:.|      ..|:..||.|.|.        |.
Mouse   139 EGEQAFGIKVRSILCCMRHQPSWSLEVLELCKKYNQ------KTVVAMDLAGDET--------IE 189

  Fly   333 QLSDLPSTANYF-----------FHAGETNWNGRTDWNMMDAI-LLNTKRIGHAFALPKHPQLWS 385
            ..|..|.....:           .||||..    :...:.:|: :|.|:|:||.:...:...|::
Mouse   190 GSSLFPGHVEAYEGAVKNGIHRTVHAGEVG----SPEVVREAVDILKTERVGHGYHTIEDEALYN 250

  Fly   386 TIKKRNIAIEVNPISNQVLGFVWD---------LRNHPASFLIAENFPIVISSDDPGVWGAKGLS 441
            .:.|.|:..||.|.|:.:.| .||         .:|..|::.:..:.|::..|.         |.
Mouse   251 RLLKENMHFEVCPWSSYLTG-AWDPKTTHAVVRFKNDKANYSLNTDDPLIFKST---------LD 305

  Fly   442 YDFYYAFMALAPADADLRF----LKQLALNSIKYAVLTSDERRKINRVFQRKWQ 491
            .|:..       ...|:.|    .|:|.:|:.|.:.|..:|::::.....|::|
Mouse   306 TDYQM-------TKKDMGFTEEEFKRLNINAAKSSFLPEEEKKELLERLYREYQ 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-D	NP_524345.2	A_deaminase_N	4..100	CDD:285627
		adm_rel	27..498	CDD:273620	80/379 (21%)
		ADGF	80..490	CDD:238646	79/376 (21%)
Ada	NP_001258981.1	ADA	8..336	CDD:238645	76/361 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810