DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Adgf-D and ada2

DIOPT Version :9

Sequence 1:	NP_524345.2	Gene:	Adgf-D / 41679	FlyBaseID:	FBgn0038172	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	XP_031754454.1	Gene:	ada2 / 100487564	XenbaseID:	XB-GENE-6258151	Length:	513	Species:	Xenopus tropicalis

Alignment Length:	512	Identity:	205/512 - (40%)
Similarity:	294/512 - (57%)	Gaps:	35/512 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VVLLTGSVQATDLPYETLREQIMEAERVASLGGNIWLSSDEEKANSILMNAKRAEIAEGLKTPEK 77
            ::||:.:..|..||..|.|..::|.|....|||||.|:..|..||..||..|.|||.|..:| ..
Frog     8 LLLLSLASAALSLPLWTKRSGLIEMEDSIRLGGNIILTPSEATANWKLMTVKEAEIKEAERT-GL 71

  Fly    78 YAPAMHFFQGRQYVRQSEVFRMIQKIPKGAFLHGHNTGMVTSRWIIQNLTTTNNLYTCRNVDGLL 142
            :.|:||||:.|..::||::|.:::::||||.||.|:..:::..|:::|.|...:.|.|...||.:
Frog    72 FPPSMHFFKARPLIQQSKIFSIVRQMPKGAALHLHDFAILSVDWLVKNATYMQDCYICFTRDGGV 136

  Fly   143 VFTYDQ--------SGCHSEVQNVCTERINAEDRGKYERQLEKHINMHGPRPEALLPNRKKIWER 199
            .|.:.:        .|| ||...:.|.|....|..::::.|.:::.:....||..:|::.:||.|
Frog   137 RFLFSKPAPVGMLPPGC-SEWVLLETYRKKLGDVTEFDKGLIRNLTLLAESPEPHIPSQDEIWRR 200

  Fly   200 FENIFTTVDRLYKYRPTYCAYHKRMLEELCEDNIIYAEIRASLSPLYDDNNRTLSTLEVANELER 264
            ||..|.|...|..|.|.:..|....|:||.||||.|.|:||.|.|:|:.:...............
Frog   201 FEGAFITASGLICYAPVFKEYFYESLKELYEDNIQYIEMRAMLPPVYELDGTVHDPFWSMALYRD 265

  Fly   265 IVEEFKAKHHDFIGVKVIYAKRNRASEEEMLRRITTFKQLHHAK------PNFVIGFDLIGQEDT 323
            :..:|...|.||:|.|:||.    ....|.|.|:|  :.:|.|.      |..:.||||:||||.
Frog   266 VTNQFIGAHPDFLGAKIIYT----VHRHEDLARVT--QAVHLAMELMKEFPEIMAGFDLVGQEDA 324

  Fly   324 GEPLNRYINQLSD---LPSTAN----YFFHAGETNWNGR-TDWNMMDAILLNTKRIGHAFALPKH 380
            |..|    .||||   :||...    ||||||||||.|: .|.|::||:||||.||||.:||.||
Frog   325 GNSL----YQLSDALNIPSKLGVKLPYFFHAGETNWQGKDVDENVLDALLLNTTRIGHGYALLKH 385

  Fly   381 PQLWSTIKKRNIAIEVNPISNQVLGFVWDLRNHPASFLIAENFPIVISSDDPGVWGAKGLSYDFY 445
            |...:...|..:.:|:.|||||||..|.|||||||:.|:||..|:|:|||||.::||:|||||.|
Frog   386 PVARNLSLKMEVPLEICPISNQVLLLVSDLRNHPAAVLMAEGHPLVVSSDDPSIFGAQGLSYDIY 450

  Fly   446 YAFMALAPADADLRFLKQLALNSIKYAVLTSDERRKINRVFQRKWQEFIANV-LNPK 501
            ...|.:..|.||||.||:||.|||||:.|:.:.:.|:..::||||.:||.:: :|.|
Frog   451 EVVMGIGGAKADLRTLKKLAENSIKYSALSKEGKAKLTEIWQRKWDKFIEDLAMNSK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-D	NP_524345.2	A_deaminase_N	4..100	CDD:285627	35/86 (41%)
		adm_rel	27..498	CDD:273620	198/493 (40%)
		ADGF	80..490	CDD:238646	173/431 (40%)
ada2	XP_031754454.1	adm_rel	25..503	CDD:273620	197/489 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H81852
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D197912at33208
OrthoFinder	1	1.000	-	-		FOG0003006
OrthoInspector	1	1.000	-	-		otm48092
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010