DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adgf-D and ADA

DIOPT Version :9

Sequence 1:	NP_524345.2	Gene:	Adgf-D / 41679	FlyBaseID:	FBgn0038172	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_000013.2	Gene:	ADA / 100	HGNCID:	186	Length:	363	Species:	Homo sapiens

Alignment Length:	368	Identity:	77/368 - (20%)
Similarity:	142/368 - (38%)	Gaps:	94/368 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 QLEKHINMHGP-RPEALL--PNRKKI------WERFENI------FTTVDRLYK---YRPTYCAY 220
            ::|.|:::.|. :||.:|  ..|:.|      .|...|:      .|..|.|.|   |.|.....
Human    11 KVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPDFLAKFDYYMPAIAGC 75

  Fly   221 H---KRMLEELCE----DNIIYAEIRASLSPLYDDNNRTLSTLEVANEL--ERIV----EEFKAK 272
            .   ||:..|..|    :.::|.|:|.|...|.:.....:...:...:|  :.:|    :..:..
Human    76 REAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQAEGDLTPDEVVALVGQGLQEG 140

  Fly   273 HHDFIGVK---VIYAKRNRAS-EEEMLRRITTFKQLHHAKPNFVIGFDLIGQEDTGEPLNRYINQ 333
            ..|| |||   ::...|::.: ..:::.....::|      ..|:..||.|.|.        |..
Human   141 ERDF-GVKARSILCCMRHQPNWSPKVVELCKKYQQ------QTVVAIDLAGDET--------IPG 190

  Fly   334 LSDLPSTANYF-----------FHAGETNWNGRTDWNMMDAILLNTKRIGHAFALPKHPQLWSTI 387
            .|.||.....:           .||||.   |..:.......:|.|:|:||.:...:...|::.:
Human   191 SSLLPGHVQAYQEAVKSGIHRTVHAGEV---GSAEVVKEAVDILKTERLGHGYHTLEDQALYNRL 252

  Fly   388 KKRNIAIEVNPISNQVLGFVWD---------LRNHPASFLIAENFPIVISSDDPGVWGAKGLSYD 443
            ::.|:..|:.|.|:.:.| .|.         |:|..|::.:..:.|::..|.         |..|
Human   253 RQENMHFEICPWSSYLTG-AWKPDTEHAVIRLKNDQANYSLNTDDPLIFKST---------LDTD 307

  Fly   444 FYYAFMALAPADADLRF----LKQLALNSIKYAVLTSDERRKI 482
            :..       ...|:.|    .|:|.:|:.|.:.|..||:|::
Human   308 YQM-------TKRDMGFTEEEFKRLNINAAKSSFLPEDEKREL 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-D	NP_524345.2	A_deaminase_N	4..100	CDD:285627
		adm_rel	27..498	CDD:273620	77/368 (21%)
		ADGF	80..490	CDD:238646	77/368 (21%)
ADA	NP_000013.2	metallo-dependent_hydrolases	9..347	CDD:320877	77/368 (21%)
ADA	NP_000013.2	Required for binding to DDP4. /evidence=ECO:0000269\|PubMed:15016824	126..143		1/16 (6%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810