DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ninaB and bco2l

DIOPT Version :9

Sequence 1:	NP_650307.2	Gene:	ninaB / 41678	FlyBaseID:	FBgn0002937	Length:	620	Species:	Drosophila melanogaster
Sequence 2:	NP_571874.1	Gene:	bco2l / 84041	ZFINID:	ZDB-GENE-010509-1	Length:	549	Species:	Danio rerio

Alignment Length:	616	Identity:	196/616 - (31%)
Similarity:	304/616 - (49%)	Gaps:	98/616 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 KYDEQRNDPQAERLDGNGRLYPNCSSDVWLRSCEREIVDPIEGHHSGHIPKWICGSLLRNGPGSW 81
            |....:..|.|..|:..|.|.          |...||.|||.....|.||.||.||.||||||.:
Zfish    11 KVPANKKRPSASGLEFIGPLV----------SSVEEIPDPITTLIKGQIPSWINGSFLRNGPGKF 65

  Fly    82 KVGDMTFGHLFDCSALLHRFAIRNGRVTYQNRFVDTETLRKNRSAQRIVVTEFGTAAVPDPCHSI 146
            :.|:..|.|.||..||:|||.|::|:|||.:||:.:::..:|....||||:||||.|.||||.:|
Zfish    66 EFGESKFTHWFDGMALMHRFNIKDGQVTYSSRFLQSDSYVQNSEKNRIVVSEFGTLATPDPCKNI 130

  Fly   147 FDRFAAIFRPDSGTDNSMISIYPFGDQYYTFTETPFMHRINPCTLATEARICTTDFVGVVNHTSH 211
            |.||.:.|:....|||:.::...:...:|..|||.||.:|:|.:|.|:.::..:.|:.|...|:|
Zfish   131 FARFFSRFQIPKTTDNAGVNFVKYKGDFYVSTETNFMRKIDPVSLETKEKVDWSKFIAVSAATAH 195

  Fly   212 PHVLPSGTVYNLGTTMTRSGPAYTILSFPHGEQMFED-----AHVVATLPCRWKLHPGYMHTFGL 271
            ||....|..||:|.:..|.|..|.||..|.||:..:|     |.::.::|......|.|.|:|.:
Zfish   196 PHYDREGATYNMGNSYGRKGFFYHILRVPPGEKQDDDADLSGAEILCSIPAADPRKPSYYHSFVM 260

  Fly   272 TDHYFVIVEQPLSVSLTEYIKAQLGGQNLSACLKWFEDRPTLFHLIDRVSGKLVQT-YESEAFFY 335
            :::|.|.:|||:.:.|.:::..::.|::....:.|..:..|:||:.||.:|:|:.| |.|.|.|.
Zfish   261 SENYIVFIEQPIKLDLLKFMLYRIAGKSFHKVMSWNPELDTIFHVADRHTGQLLNTKYYSSAMFA 325

  Fly   336 LHIINCFERDGHVVVDICSYRNPEMINCMYLEAIANMQTNPN-----YATLFRGRPLRFVLPLGT 395
            ||.||.:|.:|::::|:|...:..:|....||   |:|:...     :.:|....|.|:||||
Zfish   326 LHQINAYEENGYLIMDMCCGDDGNVIGEFTLE---NLQSTGEDLDKFFNSLCTNLPRRYVLPL-- 385

  Fly   396 IPPASIAKRGLVKSFSLAGLSAPQVSRTMKHSVSQYADITYMPTNGKQATAGEESPKRDAKRGRY 460
                                                                      :.|....
Zfish   386 ----------------------------------------------------------EVKEDEP 392

  Fly   461 EEENLVNLVTMEGSQAEAFQGTNGIQL------RPEMLCDWGCETPRIYYERYMGKNYRYFYAIS 519
            .::||:||   ..:.|.|.:...|:.|      ..::|...|.|.|:|.|..|..:.||||||..
Zfish   393 NDQNLINL---PYTTASAVKTQTGVFLYHEDLYNDDLLQYGGLEFPQINYANYNARPYRYFYACG 454

  Fly   520 SDVDAVNPGTLIKVDVWNKSCLTWCEENVYPSEPIFVPSPDPKSEDDGVILASMVLGGLNDRYVG 584
              ...|...:|:|:|:..|....|....::||||:|:|:||.:.|||||:: |:::.....:...
Zfish   455 --FGHVFGDSLLKMDLEGKKLKVWRHAGLFPSEPVFIPAPDAQDEDDGVVM-SVIITPREKKSSF 516

  Fly   585 LIVLCAKTMTELGRCDFHTNGPVPKCLHGWF 615
            |:||.|||.|||||.:...:  :|...||.|
Zfish   517 LLVLDAKTFTELGRAEVPVD--IPYGTHGLF 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ninaB	NP_650307.2	RPE65	52..617	CDD:281102	189/581 (33%)
bco2l	NP_571874.1	RPE65	35..545	CDD:281102	188/580 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581446
Domainoid	1	1.000	353	1.000	Domainoid score	I958
eggNOG	1	0.900	-	-		E1_COG3670
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12912
Inparanoid	1	1.050	357	1.000	Inparanoid score	I2188
OMA	1	1.010	-	-		QHG59724
OrthoDB	1	1.010	-	-		D342267at33208
OrthoFinder	1	1.000	-	-		FOG0000856
OrthoInspector	1	1.000	-	-		otm24986
orthoMCL	1	0.900	-	-		OOG6_100941
Panther	1	1.100	-	-	O	PTHR10543
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X319
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770