Protein Alignment ninaB and BCO2

DIOPT Version :10

• Sequence 1: NP_650307.2
• Gene: ninaB / 41678
• FlyBaseID: FBgn0002937
• Length: 620
• Species: Drosophila melanogaster
• Sequence 2: NP_114144.5
• Gene: BCO2 / 83875
• HGNCID: 18503
• Length: 579
• Species: Homo sapiens
• Alignment Length: 646
• Identity: 203/646 - (31%)
• Similarity: 305/646 - (47%)
• Gaps: 130/646 - (20%)

  Fly     5 VFKSFMRDFFAVKYDEQRNDPQAERLDGNGRLYPNCSSDVWLRSCEREIVDPIEGHHSGHIPKWI 69
            |||.:|           .|.||.:.:.|..|..| |.:.  |.:...|....|.....||.|||:
Human    30 VFKRYM-----------GNTPQKKAVFGQCRGLP-CVAP--LLTTVEEAPRGISARVWGHFPKWL 80

  Fly    70 CGSLLRNGPGSWKVGDMTFGHLFDCSALLHRFAIRNGRVTYQNRFVDTETLRKNRSAQRIVVTEF 134
            .|||||.|||.::.|...:.|.||..||||:|.:..|.|||:::|:.::|.:.|.:..|||::||
Human    81 NGSLLRIGPGKFEFGKDKYNHWFDGMALLHQFRMAKGTVTYRSKFLQSDTYKANSAKNRIVISEF 145

  Fly   135 GTAAVPDPCHSIFDRFAAIF----RPDSGTDNSMISIYPFGDQYYTFTETPFMHRINPCTLATEA 195
            ||.|:||||.::|:||.:.|    :..:.|||:.::...:...||..|||.||::::..||....
Human   146 GTLALPDPCKNVFERFMSRFELPGKAAAMTDNTNVNYVRYKGDYYLCTETNFMNKVDIETLEKTE 210

  Fly   196 RICTTDFVGVVNHTSHPHVLPSGTVYNLGTTMTRSGPAYTILSFP----------HGEQMFEDAH 250
            ::..:.|:.|...|:|||....||.||:|.:....|.:|.::..|          ||.|
Human   211 KVDWSKFIAVNGATAHPHYDLDGTAYNMGNSFGPYGFSYKVIRVPPEKVDLGETIHGVQ------ 269

  Fly   251 VVATLPCRWKLHPGYMHTFGLTDHYFVIVEQPLSVSLTEYIKAQLGGQNLSACLKWFEDRPTLFH 315
            |:.::....|..|.|.|:||:|.:|.:.:||||.::|.:...:::.|:..|..:.|.....|.||
Human   270 VICSIASTEKGKPSYYHSFGMTRNYIIFIEQPLKMNLWKIATSKIRGKAFSDGISWEPQCNTRFH 334

  Fly   316 LIDRVSGKLVQ-TYESEAFFYLHIINCFERDGHVVVDICSYRNPEMINCMYLEAIANM-----QT 374
            ::::.:|:|:. .|.|:.|...|.||.||..|.|::|:|...|...:....|:.:...     |.
Human   335 VVEKRTGQLLPGRYYSKPFVTFHQINAFEDQGCVIIDLCCQDNGRTLEVYQLQNLRKAGEGLDQV 399

  Fly   375 NPNYATLFRGRPLRFVLPLGTIPPASIAKRGLVKSFSLAGLSAPQ------VSRTMKHSVSQYAD 433
            :.:.|..|   |.||||||.                  ..|:||:      :|.|...:|.| ||
Human   400 HNSAAKSF---PRRFVLPLN------------------VSLNAPEGDNLSPLSYTSASAVKQ-AD 442

  Fly   434 ITYMPTNGKQATAGEESPKRDAKRGRYEEENLVNLVTMEGSQAEAFQGTNGIQLRPEMLCDWGCE 498
            .|...::                      |||    ..|..:.|.                 |.|
Human   443 GTIWCSH----------------------ENL----HQEDLEKEG-----------------GIE 464

  Fly   499 TPRIYYERYMGKNYRYFYA-----ISSDVDAVNPGTLIKVDVWNKSCLTWCEENVYPSEPIFVPS 558
            .|:|||:|:.||.|.:||.     :..|       :||||||.||:...|.|:..|||||:|||:
Human   465 FPQIYYDRFSGKKYHFFYGCGFRHLVGD-------SLIKVDVVNKTLKVWREDGFYPSEPVFVPA 522

  Fly   559 PDPKSEDDGVILASMVLGGLNDRYVGLIVLCAKTMTELGRCDFHTNGPV--PKCLHGWFAP 617
            |....||.||||:.::....|:... ::||.||...||||.:.    ||  |...||.|.|
Human   523 PGTNEEDGGVILSVVITPNQNESNF-ILVLDAKNFEELGRAEV----PVQMPYGFHGTFIP 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaB	NP_650307.2	RPE65	46..617	CDD:460788	191/603 (32%)
BCO2	NP_114144.5	RPE65	74..578	CDD:460788	188/586 (32%)