DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ninaB and BCO1

DIOPT Version :9

Sequence 1:	NP_650307.2	Gene:	ninaB / 41678	FlyBaseID:	FBgn0002937	Length:	620	Species:	Drosophila melanogaster
Sequence 2:	NP_059125.2	Gene:	BCO1 / 53630	HGNCID:	13815	Length:	547	Species:	Homo sapiens

Alignment Length:	585	Identity:	186/585 - (31%)
Similarity:	290/585 - (49%)	Gaps:	97/585 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 REIVDPIEGHHSGHIPKWICGSLLRNGPGSWKVGDMTFGHLFDCSALLHRFAIRNGRVTYQNRFV 115
            :|.::|:....:|.||.|:.|:|||||||...||:..:.|.||..||||.|.||:|.|.|:::::
Human    10 KEQLEPVRAKVTGKIPAWLQGTLLRNGPGMHTVGESRYNHWFDGLALLHSFTIRDGEVYYRSKYL 74

  Fly   116 DTETLRKNRSAQRIVVTEFGTAAVPDPCHSIFDR-FAAIFR--PDSGTDNSMISIYPFGDQYYTF 177
            .::|...|..|.||||:||||.|.||||.:||.: |:.:..  ||. |||.:|:|...|:.:|..
Human    75 RSDTYNTNIEANRIVVSEFGTMAYPDPCKNIFSKAFSYLSHTIPDF-TDNCLINIMKCGEDFYAT 138

  Fly   178 TETPFMHRINPCTLATEARICTTDFVGVVNHTSHPHVLPSGTVYNLGTTMTRSGPA-YTILSFP- 240
            :||.::.:|||.||.|..::....:|.|...|||||...:|.|.|:||::...|.. |.|...|
Human   139 SETNYIRKINPQTLETLEKVDYRKYVAVNLATSHPHYDEAGNVLNMGTSIVEKGKTKYVIFKIPA 203

  Fly   241 -------HGEQMFEDAHVVATLPCRWKLHPGYMHTFGLTDHYFVIVEQPLSVSLTEYIKAQLGGQ 298
                   .|:..::...|..::|.|..|.|.|.|:||:|::|.:.:|||..:.:.:...|.:...
Human   204 TVPEGKKQGKSPWKHTEVFCSIPSRSLLSPSYYHSFGVTENYVIFLEQPFRLDILKMATAYIRRM 268

  Fly   299 NLSACLKWFEDRPTLFHLIDRVSGKLVQT-YESEAFFYLHIINCFERDGHVVVDICSYRNPEMIN 362
            :.::||.:..:..|..|:||:.:.:.||| :.::|....|.:|.:|.||.:|.|:.:|.:..:..
Human   269 SWASCLAFHREEKTYIHIIDQRTRQPVQTKFYTDAMVVFHHVNAYEEDGCIVFDVIAYEDNSLYQ 333

  Fly   363 CMYLEAIANMQTNPNYATLFRGRPL--RFVLPLGTIPPASIAKRGLVKSFSLAGLSAPQVSRTMK 425
            ..||   ||:..:....:.....|.  ||.:||
Human   334 LFYL---ANLNQDFKENSRLTSVPTLRRFAVPL-------------------------------- 363

  Fly   426 HSVSQYADITYMPTNGKQATAGEESPKRDAKRGRYEEENLVNLVTMEGSQAEAFQGTNG-IQLRP 489
                 :.|        |.|..|                  .||:.:..:.|.|.:..:| :..:|
Human   364 -----HVD--------KNAEVG------------------TNLIKVASTTATALKEEDGQVYCQP 397

  Fly   490 EMLCDWGCETPRIYYERYMGKNYRYFYAISSDVDAVNPGTLIKVDVWNKSCLTWCEENVYPSEPI 554
            |.|.: |.|.||:.| .:.||.|||.:|.......: |..:||.|:..||.|.|.|::.:|:||:
Human   398 EFLYE-GLELPRVNY-AHNGKQYRYVFATGVQWSPI-PTKIIKYDILTKSSLKWREDDCWPAEPL 459

  Fly   555 FVPSPDPKSEDDGVILASMVLGGLNDRYVGLIVLCAKTMTELGRC----DFHTNGPVPKCLHGWF 615
            |||:|..|.|||||||:::|... ..:...|::|.||:.|||.|.    |.|.:      |||.|
Human   460 FVPAPGAKDEDDGVILSAIVSTD-PQKLPFLLILDAKSFTELARASVDVDMHMD------LHGLF 517

Fly 616 615
Human 518 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ninaB	NP_650307.2	RPE65	52..617	CDD:281102	186/584 (32%)
BCO1	NP_059125.2	RPE65	9..519	CDD:281102	186/585 (32%)
BCO1	NP_059125.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	528..547
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	337	1.000	Domainoid score	I1113
eggNOG	1	0.900	-	-		E1_COG3670
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	337	1.000	Inparanoid score	I2389
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59724
OrthoDB	1	1.010	-	-		D342267at33208
OrthoFinder	1	1.000	-	-		FOG0000856
OrthoInspector	1	1.000	-	-		otm40806
orthoMCL	1	0.900	-	-		OOG6_100941
Panther	1	1.100	-	-	LDO	PTHR10543
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X319
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840