DRSC/TRiP Functional Genomics Resources

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Protein Alignment f-cup and CYR1

DIOPT Version :9

Sequence 1:NP_001262544.1 Gene:f-cup / 41677 FlyBaseID:FBgn0028487 Length:802 Species:Drosophila melanogaster
Sequence 2:NP_012529.3 Gene:CYR1 / 853452 SGDID:S000003542 Length:2026 Species:Saccharomyces cerevisiae


Alignment Length:764 Identity:159/764 - (20%)
Similarity:269/764 - (35%) Gaps:227/764 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    82 FRPIFHERSTHEDDQVLTQELWKLARKSGT-LNLSNKALARVPKRLY----DINEADADSKAVNL 141
            |.|:.....|.|.:|       ::.|.... ::|.|..|...|...|    :|...|..:.|...
Yeast   773 FHPVTPSHFTPEQEQ-------RIMRSEFVHVDLRNMDLTTPPIIFYQHTSEIESLDVSNNANIF 830

  Fly   142 EQLTIKEEDAWWNQVPLNNLDLSSNTLTHISPKIENLQSLTVLTLHDNALVELPPEIGKLEKLVR 206
            ..|...|     :.:.|.:|.:.:...:.....|.....|..|.|..|.:.::|..|.||..|..
Yeast   831 LPLEFIE-----SSIKLLSLRMVNIRASKFPSNITKAYKLVSLELQRNFIRKVPNSIMKLSNLTI 890

  Fly   207 LNVSHNKLSQLPRAMYSLPELRHLNISYNEFVELNPDISDLHMLEFLDGGHNNIQSLPGGIGFLV 271
            ||:..|:|..||.....|..|:.|::|.|:|:.....|:....|..:|..:|.|||||....:||
Yeast   891 LNLQCNELESLPAGFVELKNLQLLDLSSNKFMHYPEVINYCTNLLQIDLSYNKIQSLPQSTKYLV 955

  Fly   272 RLTALLLPYNHIKELPPDLVNMRSLQKIDLMHNDLTSLPEDMGLLR-----------------KL 319
            :|..:.|.:|.:..: .||..|..|:.::|.:|.::|:..:...|:                 ||
Yeast   956 KLAKMNLSHNKLNFI-GDLSEMTDLRTLNLRYNRISSIKTNASNLQNLFLTDNRISNFEDTLPKL 1019

  Fly   320 DCLYLQHNDILEL------PEFEGNEALNELHASNNFIKIIPKAMCSNLPHLKILDLRDNKITEL 378
            ..|.:|.|.|..:      |:...:..||:...|:     ||..:.:.|..|:.|:|..|.:|.|
Yeast  1020 RALEIQENPITSISFKDFYPKNMTSLTLNKAQLSS-----IPGELLTKLSFLEKLELNQNNLTRL 1079

  Fly   379 PDELCLLRNLNRLDVSNNTISVLPVTLSSLAHLISLQVEGNPIKTIRRDILQCGTTRILKTLHDR 443
            |.|:..|..|..|.|:.|.:..:|..||.|..|.:|.:..|.|    ||.:.             
Yeast  1080 PQEISKLTKLVFLSVARNKLEYIPPELSQLKSLRTLDLHSNNI----RDFVD------------- 1127

  Fly   444 AVAKAKEEGGGVDDAS-TSAGISVTRLRGGQMDDGDIPGNFPDSFHHQQQQNGFQCPCSYPCQQQ 507
                      |:::.. ||..||                  .::|.:...:|.|....||..:..
Yeast  1128 ----------GMENLELTSLNIS------------------SNAFGNSSLENSFYHNMSYGSKLS 1164

  Fly   508 QMQQQFCVYE--------PLRNCQEYDRQTQGRIYEPENYQQQHQNGSLRSLFVQQQQQRMEYPY 564
            :....|...:        ||.||                                          
Yeast  1165 KSLMFFIAADNQFDDAMWPLFNC------------------------------------------ 1187

  Fly   565 PGYFMYQQQQQQQFSYEQDPSSRSAVHPRWVYKLRHTRTLAVNLEELTSVPDQVFQIARDEGVHV 629
                                                    .|||:                   |
Yeast  1188 ----------------------------------------FVNLK-------------------V 1193

  Fly   630 VDFARNQLSTLPNGLQHMK-DLVTELVLSNNVIGYVP-QFISQFTRISFLNLSNNLLNDLPTEFG 692
            ::.:.|..|    .:.||| :.:|||.||.|.:..:. ..:.:::.:..|.|::|.:..||.|..
Yeast  1194 LNLSYNNFS----DVSHMKLESITELYLSGNKLTTLSGDTVLKWSSLKTLMLNSNQMLSLPAELS 1254

  Fly   693 VLNTLRELNIANNRFPC-IPNCVYELQGLEILIASENHIKMLNVSGLQNMRRLSTLDLRNNDIET 756
            .|:.|...::..|:... |.|..|:...     .:...:|.||.||   .||.......::||:.
Yeast  1255 NLSQLSVFDVGANQLKYNISNYHYDWNW-----RNNKELKYLNFSG---NRRFEIKSFISHDIDA 1311

  Fly   757 VPPILGNLTNITHLELVG------NPFRQPRHQI--LMKGTDAIMSYLR 797
               .|.:||.:..|:::|      |..:.|...:  .::.|.:|::.:|
Yeast  1312 ---DLSDLTVLPQLKVLGLMDVTLNTTKVPDENVNFRLRTTASIINGMR 1357

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
f-cupNP_001262544.1 leucine-rich repeat 111..140 CDD:275380 8/33 (24%)
LRR_RI 155..>377 CDD:238064 63/244 (26%)
leucine-rich repeat 158..180 CDD:275380 3/21 (14%)
LRR_8 180..235 CDD:290566 19/54 (35%)
leucine-rich repeat 181..203 CDD:275380 8/21 (38%)
leucine-rich repeat 204..226 CDD:275380 8/21 (38%)
LRR_8 225..283 CDD:290566 19/57 (33%)
leucine-rich repeat 227..249 CDD:275380 6/21 (29%)
leucine-rich repeat 250..272 CDD:275380 9/21 (43%)
LRR_8 272..329 CDD:290566 16/73 (22%)
leucine-rich repeat 273..295 CDD:275380 6/21 (29%)
leucine-rich repeat 296..318 CDD:275380 5/38 (13%)
LRR_8 317..375 CDD:290566 17/80 (21%)
leucine-rich repeat 319..340 CDD:275380 6/26 (23%)
leucine-rich repeat 341..364 CDD:275380 6/22 (27%)
leucine-rich repeat 389..410 CDD:275380 7/20 (35%)
leucine-rich repeat 411..430 CDD:275380 6/18 (33%)
leucine-rich repeat 627..650 CDD:275380 6/23 (26%)
leucine-rich repeat 651..669 CDD:275380 6/18 (33%)
leucine-rich repeat 697..719 CDD:275380 5/22 (23%)
LRR_8 719..777 CDD:290566 15/63 (24%)
leucine-rich repeat 720..743 CDD:275380 5/22 (23%)
leucine-rich repeat 744..766 CDD:275380 4/21 (19%)
CYR1NP_012529.3 Ad_cyc_g-alpha 368..418 CDD:369912
RA_PHLPP_like 678..776 CDD:340473 1/2 (50%)
PLN00113 792..>1273 CDD:215061 131/641 (20%)
leucine-rich repeat 796..817 CDD:275380 5/20 (25%)
leucine-rich repeat 818..839 CDD:275380 5/25 (20%)
leucine-rich repeat 840..864 CDD:275380 3/23 (13%)
leucine-rich repeat 865..887 CDD:275380 8/21 (38%)
leucine-rich repeat 888..910 CDD:275380 8/21 (38%)
leucine-rich repeat 911..933 CDD:275380 6/21 (29%)
leucine-rich repeat 934..956 CDD:275380 9/21 (43%)
leucine-rich repeat 957..978 CDD:275380 6/21 (29%)
leucine-rich repeat 979..1018 CDD:275380 5/38 (13%)
leucine-rich repeat 1019..1041 CDD:275380 6/21 (29%)
leucine-rich repeat 1042..1065 CDD:275380 6/27 (22%)
leucine-rich repeat 1066..1088 CDD:275380 9/21 (43%)
leucine-rich repeat 1089..1111 CDD:275380 8/21 (38%)
leucine-rich repeat 1167..1187 CDD:275380 3/19 (16%)
leucine-rich repeat 1191..1211 CDD:275380 7/42 (17%)
leucine-rich repeat 1236..1258 CDD:275380 7/21 (33%)
leucine-rich repeat 1259..1287 CDD:275380 5/32 (16%)
PP2C 1374..1617 CDD:395385
CYCc 1613..1825 CDD:214485
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157345011
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

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