DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment f-cup and PIRL3

DIOPT Version :9

Sequence 1:	NP_001262544.1	Gene:	f-cup / 41677	FlyBaseID:	FBgn0028487	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_563921.1	Gene:	PIRL3 / 837855	AraportID:	AT1G12970	Length:	464	Species:	Arabidopsis thaliana

Alignment Length:	372	Identity:	101/372 - (27%)
Similarity:	156/372 - (41%)	Gaps:	68/372 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 KRLYDINEADADSKAVNLEQLT----IKEE------DAWWNQVPLNNLDLSSNTLTHISPKIENL 178
            |:|.|:.|......|..:|.|:    :.||      ||....| :..:|||.:.|..:...:..:
plant   120 KQLRDLEEEIGRVYASAVESLSGGDEVNEEVLAVIKDAEDGGV-VERIDLSDHELKLLPDALGKI 183

  Fly   179 QSLTVLTLHDNALVELPPEIGKLEKLVRLNVSHNKLSQLPRAMYSLPELRHLNISYNEFVELNPD 243
            ..|..|.:..|.|..||..|..||||..|::|.|:|..||.::..|..||.||::.|:...|...
plant   184 VGLVSLNVSRNNLRFLPDTISGLEKLEELDLSSNRLVFLPDSIGLLLNLRILNVTGNKLTLLPES 248

  Fly   244 ISDLHMLEFLDGGHNNIQSLPGGIGF-LVRLTALLLPYNHIKELPPDLVNMRSLQKIDLMHNDLT 307
            |:....|..||...||:.|||...|: |:.|..|.:..|.|:..|..:..||||:.:|...|::.
plant   249 IAQCRSLVELDASFNNLTSLPANFGYGLLNLERLSIQLNKIRFFPNSICEMRSLRYLDAHMNEIH 313

  Fly   308 SLPEDMGLLRKLDCLYLQHNDILELPEFEGNEALNELHASNNFIKIIPKAMCSNLPHLKILDLRD 372
            .||..:|.|..|:.:.|                      |:||..:|
plant   314 GLPIAIGRLTNLEVMNL----------------------SSNFSDLI------------------ 338

  Fly   373 NKITELPDELCLLRNLNRLDVSNNTISVLPVTLSSLAHLISLQVEGNPIKTIRRDILQCGTTRIL 437
                ||||.:..|.||..||:|||.|.|||.:...|..|..|.::.||::...::::......:.
plant   339 ----ELPDTISDLANLRELDLSNNQIRVLPDSFFRLEKLEKLNLDQNPLEYPPQEMVNQSAEAVR 399

  Fly   438 KTLHDR------------AVAKAKEEGGGVDDASTSAGISVTRLRGG 472
            :.:..|            .:...|::||.....|..:.|..:...||
plant   400 EFMRKRWEEMVEEEQLRSVIEAEKQQGGATGWLSWGSSIVTSLFSGG 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
f-cup	NP_001262544.1	leucine-rich repeat	111..140	CDD:275380	5/15 (33%)
		LRR_RI	155..>377	CDD:238064	61/222 (27%)
		leucine-rich repeat	158..180	CDD:275380	4/21 (19%)
		LRR_8	180..235	CDD:290566	22/54 (41%)
		leucine-rich repeat	181..203	CDD:275380	8/21 (38%)
		leucine-rich repeat	204..226	CDD:275380	8/21 (38%)
		LRR_8	225..283	CDD:290566	20/58 (34%)
		leucine-rich repeat	227..249	CDD:275380	7/21 (33%)
		leucine-rich repeat	250..272	CDD:275380	10/22 (45%)
		LRR_8	272..329	CDD:290566	17/56 (30%)
		leucine-rich repeat	273..295	CDD:275380	6/21 (29%)
		leucine-rich repeat	296..318	CDD:275380	7/21 (33%)
		LRR_8	317..375	CDD:290566	6/57 (11%)
		leucine-rich repeat	319..340	CDD:275380	2/20 (10%)
		leucine-rich repeat	341..364	CDD:275380	4/22 (18%)
		leucine-rich repeat	389..410	CDD:275380	10/20 (50%)
		leucine-rich repeat	411..430	CDD:275380	4/18 (22%)
		leucine-rich repeat	627..650	CDD:275380
		leucine-rich repeat	651..669	CDD:275380
		leucine-rich repeat	697..719	CDD:275380
		LRR_8	719..777	CDD:290566
		leucine-rich repeat	720..743	CDD:275380
		leucine-rich repeat	744..766	CDD:275380
PIRL3	NP_563921.1	leucine-rich repeat	163..185	CDD:275380	4/21 (19%)
		LRR	<185..385	CDD:227223	77/243 (32%)
		leucine-rich repeat	186..208	CDD:275380	8/21 (38%)
		leucine-rich repeat	209..231	CDD:275380	8/21 (38%)
		leucine-rich repeat	232..254	CDD:275380	7/21 (33%)
		leucine-rich repeat	255..278	CDD:275380	10/22 (45%)
		leucine-rich repeat	279..301	CDD:275380	6/21 (29%)
		leucine-rich repeat	302..324	CDD:275380	7/21 (33%)
		leucine-rich repeat	325..349	CDD:275380	11/67 (16%)
		leucine-rich repeat	350..372	CDD:275380	11/21 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45752
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010