DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment f-cup and PIRL2

DIOPT Version :9

Sequence 1:	NP_001262544.1	Gene:	f-cup / 41677	FlyBaseID:	FBgn0028487	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_189281.2	Gene:	PIRL2 / 822257	AraportID:	AT3G26500	Length:	471	Species:	Arabidopsis thaliana

Alignment Length:	472	Identity:	121/472 - (25%)
Similarity:	214/472 - (45%)	Gaps:	77/472 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 SNPS-----TSRIPRSAQSPRQASVVHSPRTNCAFRPIFHERSTHEDDQVLTQELWKLARKSGTL 112
            |||.     |..||.:.             |...|  :|:...:..|...::...:|:|:...:|
plant    42 SNPEIMSMLTQSIPTTI-------------TQTLF--VFNSLGSRPDPLAVSSARFKIAQIMDSL 91

  Fly   113 NLSNKALARVPKRLYDINEADADSKAVNLEQLTIKEEDAWWNQVPLNNLDLSSNTLTHISPKIEN 177
            :....|           .|::..:..|.|:::    .|::..::.....:||....|.:...:.:
plant    92 SPEEAA-----------KESEIYAGVVRLDEV----HDSYEKKLKDTEEELSRVYSTEVESMLRS 141

  Fly   178 LQSLTVLTLHDNALVELPPEIGKLEKLVRLNVSHNKLSQLPRAMYSLPELRHLNISYNEFVELNP 242
            .:.:....|   |:::.....|.:|   |:::|..:|..:|.|.:.:..|.:||:|.|:...:..
plant   142 GEEVNEKVL---AVLKEAESGGTVE---RIDLSSQELKLIPEAFWKVVGLVYLNLSGNDLTFIPD 200

  Fly   243 DISDLHMLEFLDGGHNNIQSLPGGIGFLVRLTALLLPYNHIKELPPDLVNMRSLQKIDLMHNDLT 307
            .||.|..||.||...|:::|||..||.|:.|..|.:..|::..||..:.:.|||.::|..:|:||
plant   201 AISKLKKLEELDVSSNSLESLPDSIGMLLNLRILNVNANNLTALPESIAHCRSLVELDASYNNLT 265

  Fly   308 SLPEDMGL-LRKLDCLYLQHNDILELPEFEGNEA----LNELHASNNFIKIIPKAMCSNLPHLKI 367
            |||.::|. |:.|:.|.:|.|   :|..|.|:.:    |..|.|..|.|..||.:: ..|..|::
plant   266 SLPTNIGYGLQNLERLSIQLN---KLRYFPGSISEMYNLKYLDAHMNEIHGIPNSI-GRLTKLEV 326

  Fly   368 LDLRD--NKITELPDELCLLRNLNRLDVSNNTISVLPVTLSSLAHLISLQVEGNPIKTIRRDILQ 430
            |:|..  |.:..:||.:..|.||..||:|||.|..:|.:...|..|..|.::.||::...:::..
plant   327 LNLSSNFNNLMGVPDTITDLTNLRELDLSNNQIQAIPDSFYRLRKLEKLNLDQNPLEIPSQEVAT 391

  Fly   431 CGTTRILKTLHDR--AVAKAKEEGGGVDDA-----------STS------AGISVTRLRGGQMDD 476
            .|...:.:.:..|  .:...:::..||:..           .||      :|::.|...||...|
plant   392 QGAEVVREFMRKRWGDIMAEQQQRIGVEAERHGDENGWVYWGTSMVTNLVSGVTHTIGFGGATSD 456

  Fly   477 G--DIPGNFPDS-FHHQ 490
            |  ..||   || |:||
plant   457 GGDKKPG---DSYFYHQ 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
f-cup	NP_001262544.1	leucine-rich repeat	111..140	CDD:275380	3/28 (11%)
		LRR_RI	155..>377	CDD:238064	67/228 (29%)
		leucine-rich repeat	158..180	CDD:275380	3/21 (14%)
		LRR_8	180..235	CDD:290566	13/54 (24%)
		leucine-rich repeat	181..203	CDD:275380	3/21 (14%)
		leucine-rich repeat	204..226	CDD:275380	5/21 (24%)
		LRR_8	225..283	CDD:290566	22/57 (39%)
		leucine-rich repeat	227..249	CDD:275380	8/21 (38%)
		leucine-rich repeat	250..272	CDD:275380	11/21 (52%)
		LRR_8	272..329	CDD:290566	21/57 (37%)
		leucine-rich repeat	273..295	CDD:275380	5/21 (24%)
		leucine-rich repeat	296..318	CDD:275380	10/22 (45%)
		LRR_8	317..375	CDD:290566	19/63 (30%)
		leucine-rich repeat	319..340	CDD:275380	7/20 (35%)
		leucine-rich repeat	341..364	CDD:275380	8/22 (36%)
		leucine-rich repeat	389..410	CDD:275380	8/20 (40%)
		leucine-rich repeat	411..430	CDD:275380	4/18 (22%)
		leucine-rich repeat	627..650	CDD:275380
		leucine-rich repeat	651..669	CDD:275380
		leucine-rich repeat	697..719	CDD:275380
		LRR_8	719..777	CDD:290566
		leucine-rich repeat	720..743	CDD:275380
		leucine-rich repeat	744..766	CDD:275380
PIRL2	NP_189281.2	leucine-rich repeat	162..184	CDD:275380	6/24 (25%)
		LRR_RI	169..408	CDD:238064	77/242 (32%)
		LRR_8	184..241	CDD:290566	22/56 (39%)
		leucine-rich repeat	185..207	CDD:275380	8/21 (38%)
		leucine-rich repeat	208..230	CDD:275380	11/21 (52%)
		LRR_8	230..288	CDD:290566	21/60 (35%)
		leucine-rich repeat	231..253	CDD:275380	5/21 (24%)
		leucine-rich repeat	254..277	CDD:275380	10/22 (45%)
		leucine-rich repeat	278..300	CDD:275380	7/24 (29%)
		leucine-rich repeat	301..323	CDD:275380	8/22 (36%)
		LRR_8	322..382	CDD:290566	20/59 (34%)
		leucine-rich repeat	324..348	CDD:275380	7/23 (30%)
		leucine-rich repeat	349..371	CDD:275380	9/21 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45752
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010