DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment f-cup and Lrrc40

DIOPT Version :9

Sequence 1:	NP_001262544.1	Gene:	f-cup / 41677	FlyBaseID:	FBgn0028487	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_077156.2	Gene:	Lrrc40 / 67144	MGIID:	1914394	Length:	602	Species:	Mus musculus

Alignment Length:	743	Identity:	233/743 - (31%)
Similarity:	350/743 - (47%)	Gaps:	147/743 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 RSAQSPRQASVVHSPRTNCAFRPIFHERSTHEDDQVLTQELWKLARKSGTLNLSNKALARVPKRL 126
            |..::||     ..||..      ||.........| .|.|.|.||.||.|||:.:.|..||:.:
Mouse     3 RQLRAPR-----FDPRAG------FHAEGKDRGPSV-PQGLLKAARSSGQLNLAGRNLGEVPQCV 55

  Fly   127 YDINEADADSKAVNLEQLTIKEEDAWWNQVPLNNLDLSSNTLTHISPKIENLQSLTVLTLHDNAL 191
            :.|| .|...:|  .:.|:....:.||:|..|..|.:|||.|..:|..:..|.:||||.:|||.|
Mouse    56 WRIN-VDIPEEA--NQNLSFSSTERWWDQTDLTKLIISSNKLQSLSDDLRLLPALTVLDIHDNQL 117

  Fly   192 VELPPEIGKLEKLVRLNVSHNKLSQLPRAMYSLPELRHLNISYNEFVELNPDISDLHMLEFLDGG 256
            ..||..|.:|:.|.:||||||||..||..:.||..||.|::.:||...:......|..||.||..
Mouse   118 TSLPSAIRELDNLQKLNVSHNKLKILPEEITSLKNLRTLHLQHNELTCIPEGFEHLSCLEDLDLS 182

  Fly   257 HNNIQSLPGGIGFLVRLTALLLPYNHIKELPPDLVNMRSLQKIDLMHNDLTSLPEDMGLLRKLDC 321
            .|.:.::|.....|..|..|.|..|.:|.||.::..|:.|:.:|...|.|.::|.|:|.:..|:.
Mouse   183 SNRLATVPADFALLSSLLRLNLSSNQLKNLPAEISRMKRLKHLDCDANLLETVPPDVGSMESLEL 247

  Fly   322 LYLQHNDILELPEFEGNEALNELHASNNFIKIIPKAMCSNLPHLK---ILDLRDNKITELPDELC 383
            |||:.|.:..||||.....|.|||.:.|.|:   |....:|.||:   :||||.||:..:|:|:.
Mouse   248 LYLRRNKLRVLPEFPSCRQLKELHLAENQIE---KLGAEHLQHLQAILVLDLRGNKLRSVPEEMA 309

  Fly   384 LLRNLNRLDVSNNTISVLPVTLSSLAHLISLQVEGNPIKTIRRDILQCGTTRILKTLHDRAVAKA 448
            ||::|.|||:|||.||.||.:|.:| ||..|.:||||::||||:|:..||..:||.|.    :|.
Mouse   310 LLQSLERLDLSNNDISSLPCSLGNL-HLKFLALEGNPLRTIRREIIAKGTQEVLKYLR----SKI 369

  Fly   449 KEEGGGVDDASTSAGISVTRLRGGQMDDGDIPGNFPDSFHHQQQQNGFQCPCSYPCQQQQMQQQF 513
            |::
Mouse   370 KDD-------------------------------------------------------------- 372

  Fly   514 CVYEPLRNCQEYDRQTQGRIYEPENYQQQHQNGSLRSLFVQQQQQRMEYPYPGYFMYQQQQQQQF 578
                                       :.:||.|:       .:..|..|
Mouse   373 ---------------------------RTNQNDSV-------PETAMTLP--------------- 388

  Fly   579 SYEQDPSSRSAVHPRWVYKLRHTRTLAVNLEELTSVPDQVFQIARDEGVHVVDFARNQLSTLPNG 643
                 ..:|..:|.....||     |..:.::.|.:||.:|...:...:..::|::|||..:|..
Mouse   389 -----SEARVNIHAIATLKL-----LDYSDKQATLIPDDLFDATKTTLITSINFSKNQLCEIPQR 443

  Fly   644 LQHMKDLVTELVLSNNVIGYVPQFISQFTRISFLNLSNNLLNDLPTEFGVLNTLRELNIANNRFP 708
            :..:|::|.::.||.|.:.::...:....:::||:|.||.|:.||.|...|..|:.:|::.|||.
Mouse   444 IVELKEMVLDINLSFNKLSFISHELCLLQKLTFLDLRNNFLSSLPEEMSSLTKLQTINLSFNRFK 508

  Fly   709 CIPNCVYELQGLEILIASENHIKMLNVSGLQNMRRLSTLDLRNNDIETVPPILGNLTNITHLELV 773
            ..|..:|.:..||.::.|.|.:..::...::.|..|:||||:|||:..:||.|||...:..|.|.
Mouse   509 VFPEVLYRISTLEAVLISNNQVGSVDPQKMKLMENLNTLDLQNNDLLQIPPELGNCVQLRTLLLD 573

  Fly   774 GNPFRQPRHQILMKGTDAIMSYLRDRIP 801
            |||||.||..||||||.|::.|||||||
Mouse   574 GNPFRVPRAAILMKGTAAVLEYLRDRIP 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
f-cup	NP_001262544.1	leucine-rich repeat	111..140	CDD:275380	10/28 (36%)
		LRR_RI	155..>377	CDD:238064	87/224 (39%)
		leucine-rich repeat	158..180	CDD:275380	8/21 (38%)
		LRR_8	180..235	CDD:290566	28/54 (52%)
		leucine-rich repeat	181..203	CDD:275380	12/21 (57%)
		leucine-rich repeat	204..226	CDD:275380	13/21 (62%)
		LRR_8	225..283	CDD:290566	17/57 (30%)
		leucine-rich repeat	227..249	CDD:275380	6/21 (29%)
		leucine-rich repeat	250..272	CDD:275380	7/21 (33%)
		LRR_8	272..329	CDD:290566	20/56 (36%)
		leucine-rich repeat	273..295	CDD:275380	8/21 (38%)
		leucine-rich repeat	296..318	CDD:275380	7/21 (33%)
		LRR_8	317..375	CDD:290566	24/60 (40%)
		leucine-rich repeat	319..340	CDD:275380	9/20 (45%)
		leucine-rich repeat	341..364	CDD:275380	8/22 (36%)
		leucine-rich repeat	389..410	CDD:275380	12/20 (60%)
		leucine-rich repeat	411..430	CDD:275380	11/18 (61%)
		leucine-rich repeat	627..650	CDD:275380	6/22 (27%)
		leucine-rich repeat	651..669	CDD:275380	4/17 (24%)
		leucine-rich repeat	697..719	CDD:275380	7/21 (33%)
		LRR_8	719..777	CDD:290566	22/57 (39%)
		leucine-rich repeat	720..743	CDD:275380	5/22 (23%)
		leucine-rich repeat	744..766	CDD:275380	13/21 (62%)
Lrrc40	NP_077156.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		7/33 (21%)
		LRR 1	35..58		10/22 (45%)
		leucine-rich repeat	38..83	CDD:275380	16/47 (34%)
		LRR 2	81..103		8/21 (38%)
		LRR_8	84..140	CDD:290566	27/55 (49%)
		leucine-rich repeat	84..106	CDD:275380	8/21 (38%)
		LRR_RI	101..368	CDD:238064	113/274 (41%)
		LRR 3	104..126		12/21 (57%)
		leucine-rich repeat	107..129	CDD:275380	12/21 (57%)
		LRR 4	127..149		12/21 (57%)
		LRR_8	129..186	CDD:290566	24/56 (43%)
		leucine-rich repeat	130..152	CDD:275380	13/21 (62%)
		LRR 5	150..172		6/21 (29%)
		leucine-rich repeat	153..175	CDD:275380	6/21 (29%)
		LRR 6	174..195		6/20 (30%)
		leucine-rich repeat	176..221	CDD:275380	15/44 (34%)
		LRR 7	196..219		8/22 (36%)
		LRR_8	220..277	CDD:290566	21/56 (38%)
		LRR 8	221..241		6/19 (32%)
		leucine-rich repeat	222..244	CDD:275380	7/21 (33%)
		LRR 9	242..266		9/23 (39%)
		leucine-rich repeat	245..266	CDD:275380	9/20 (45%)
		LRR_RI	248..505	CDD:238064	96/385 (25%)
		LRR_8	265..324	CDD:290566	27/61 (44%)
		leucine-rich repeat	267..290	CDD:275380	10/25 (40%)
		LRR 10	268..287		7/21 (33%)
		LRR 11	288..310		9/21 (43%)
		leucine-rich repeat	291..313	CDD:275380	10/21 (48%)
		LRR 12	311..334		13/22 (59%)
		LRR 13	336..356		11/19 (58%)
		leucine-rich repeat	365..473	CDD:275380	27/232 (12%)
		LRR 14	398..421		7/27 (26%)
		LRR 15	424..447		5/22 (23%)
		LRR 16	449..470		4/20 (20%)
		LRR_8	454..507	CDD:290566	16/52 (31%)
		LRR 17	471..494		9/22 (41%)
		LRR 18	496..517		7/20 (35%)
		leucine-rich repeat	497..519	CDD:275380	7/21 (33%)
		LRR_8	518..577	CDD:290566	22/58 (38%)
		LRR 19	519..540		4/20 (20%)
		leucine-rich repeat	520..543	CDD:275380	5/22 (23%)
		LRR 20	541..564		13/22 (59%)
		LRR 21	566..587		11/20 (55%)
		leucine-rich repeat	567..578	CDD:275378	5/10 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0472
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9825
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54393
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005608
OrthoInspector	1	1.000	-	-		oto92710
orthoMCL	1	0.900	-	-		OOG6_102107
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5134
SonicParanoid	1	1.000	-	-		X4580
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.710