DRSC/TRiP Functional Genomics Resources

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Protein Alignment f-cup and Phlpp1

DIOPT Version :9

Sequence 1:NP_001262544.1 Gene:f-cup / 41677 FlyBaseID:FBgn0028487 Length:802 Species:Drosophila melanogaster
Sequence 2:XP_038946976.1 Gene:Phlpp1 / 59265 RGDID:621308 Length:1718 Species:Rattus norvegicus


Alignment Length:687 Identity:147/687 - (21%)
Similarity:266/687 - (38%) Gaps:202/687 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   145 TIKEEDAWWNQVP------LNNLDLSSNTLTHISPKIENLQSLTVLTLHDNALVELPP------- 196
            |..|...|..||.      ::::|||..:|.|:...:...|.||.|.|..|.|.:.|.       
  Rat   583 TFTEYLRWLRQVSKVASQRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGL 647

  Fly   197 -EIGKLEKLVRLNVSHNKLSQLPRAMYSLPELRHLNISYNEFVELNPDISDLHMLEFLDGGHNNI 260
             |:.:..||..||:|:|.|...|.|:.|:|.|..||:|.|.                       :
  Rat   648 GELQRFTKLKSLNLSNNHLGAFPSAVCSIPTLAELNVSCNA-----------------------L 689

  Fly   261 QSLPGGIGFLVRLTALLLPYNHIKELPPDLVNMRSLQKIDLMHNDLTSLPEDMGLLRKLDCLYLQ 325
            :.:|..:|.:..|...||..|.::.||.:|.||..|..:.|..|:.|.:||   :|.||      
  Rat   690 REVPAAVGAMQNLQTFLLDGNFLQSLPAELENMHQLSYLGLSFNEFTDIPE---VLEKL------ 745

  Fly   326 HNDILELPEFEGNEALNELHASNNFIKIIPKAMCSNLPHLKILDLRDNKITEL-PDELCLLRNLN 389
                         .|:::|..:.|.::.:.......:||:|.:|||.|.:.:| .||:..|:::.
  Rat   746 -------------TAVDKLCMAGNCMETLRLQALRRMPHIKHVDLRLNILRKLITDEVDFLQHVT 797

  Fly   390 RLDVSNNTISVLPVTLSSLAHLISLQVEGNPIKTIRRDILQCGTTRILKTLHDRAVAKAKEEGGG 454
            :||:.:|.:..|...:.:  ::..|..|.|.:.|:.    .||  ..||.|:             
  Rat   798 QLDLRDNKLGDLDAMIFN--NIEVLHCERNQLVTLN----ICG--YFLKALY------------- 841

  Fly   455 VDDASTSAGISVTRLRGGQMDDGDIPGNFPDSFHHQQQQNGFQCPCSYPCQQQQMQ------QQF 513
               ||::..:        |:|...:|....   :....:|..:....:.|:.::::      .|.
  Rat   842 ---ASSNELV--------QLDVYPVPNYLS---YMDVSRNCLESVPEWVCESRKLEVLDIGHNQI 892

  Fly   514 CVYEPLRNCQEYDRQTQGRIYEPENYQQQHQNGSLRSLFVQQQQ-----QRMEYPYPGYFMYQQQ 573
            |             :...|::         .|.|||.|.....:     :|:|            
  Rat   893 C-------------ELPARLF---------CNSSLRKLLAGHNRLARLPERLE------------ 923

  Fly   574 QQQQFSYEQDPSSRSAVHPRWVYKLRHTRTLAVNLEELTSVPDQVFQIARDEGVHVVDFARNQLS 638
                         |::|           ..|.|...::..:|..:  :.:.:.:..::.:.|:|.
  Rat   924 -------------RTSV-----------EVLDVQHNQIIELPPNL--LMKADSLRFLNASANKLE 962

  Fly   639 TLPNGL--QHMKDLVTELVLSNNVI--GYVPQFISQFTRISFLNLSNNLLNDLP-TEFGVLNTLR 698
            |||...  :....::.||.|:||.:  ..|| .::...|:..|:::.|.|...| ::...|..|.
  Rat   963 TLPPATLSEETSSILQELYLTNNSLTDKCVP-LLTGHPRLKILHMAYNRLQSFPASKMAKLEELE 1026

  Fly   699 ELNIANNRFPCIPNCVYELQGLEILIASENHIKML----------NVSGLQNMRRLSTL------ 747
            |::|:.|:...||..:...:.:..:||..|.|::.          :..|..::.|.|.|      
  Rat  1027 EIDISGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPEVMQLPEVKSTEGNGSLSRSSFLFPLFHQ 1091

  Fly   748 --DLRNNDI------ETVPPILGNLTNITHLELVGNP 776
              ||..|::      |.:||      .:..|:|.|||
  Rat  1092 CVDLSCNELSEITLPENLPP------KLQELDLTGNP 1122

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
f-cupNP_001262544.1 leucine-rich repeat 111..140 CDD:275380
LRR_RI 155..>377 CDD:238064 62/235 (26%)
leucine-rich repeat 158..180 CDD:275380 5/21 (24%)
LRR_8 180..235 CDD:290566 23/62 (37%)
leucine-rich repeat 181..203 CDD:275380 8/29 (28%)
leucine-rich repeat 204..226 CDD:275380 9/21 (43%)
LRR_8 225..283 CDD:290566 12/57 (21%)
leucine-rich repeat 227..249 CDD:275380 5/21 (24%)
leucine-rich repeat 250..272 CDD:275380 2/21 (10%)
LRR_8 272..329 CDD:290566 18/56 (32%)
leucine-rich repeat 273..295 CDD:275380 9/21 (43%)
leucine-rich repeat 296..318 CDD:275380 7/21 (33%)
LRR_8 317..375 CDD:290566 12/57 (21%)
leucine-rich repeat 319..340 CDD:275380 1/20 (5%)
leucine-rich repeat 341..364 CDD:275380 2/22 (9%)
leucine-rich repeat 389..410 CDD:275380 4/20 (20%)
leucine-rich repeat 411..430 CDD:275380 4/18 (22%)
leucine-rich repeat 627..650 CDD:275380 5/24 (21%)
leucine-rich repeat 651..669 CDD:275380 7/19 (37%)
leucine-rich repeat 697..719 CDD:275380 6/21 (29%)
LRR_8 719..777 CDD:290566 19/82 (23%)
leucine-rich repeat 720..743 CDD:275380 5/32 (16%)
leucine-rich repeat 744..766 CDD:275380 8/35 (23%)
Phlpp1XP_038946976.1 Ubiquitin_like_fold 176..>224 CDD:421700
PHA03247 <237..443 CDD:223021
RA_PHLPP1 <424..491 CDD:340760
PH_PHLPP-like 498..594 CDD:270131 3/10 (30%)
PLN00113 602..>1109 CDD:215061 135/647 (21%)
leucine-rich repeat 604..624 CDD:275380 5/19 (26%)
leucine-rich repeat 625..655 CDD:275380 8/29 (28%)
leucine-rich repeat 679..701 CDD:275380 7/44 (16%)
leucine-rich repeat 702..724 CDD:275380 9/21 (43%)
leucine-rich repeat 725..771 CDD:275380 12/67 (18%)
leucine-rich repeat 772..795 CDD:275380 9/22 (41%)
leucine-rich repeat 796..816 CDD:275380 4/21 (19%)
leucine-rich repeat 817..858 CDD:275380 14/70 (20%)
leucine-rich repeat 859..881 CDD:275380 2/24 (8%)
leucine-rich repeat 882..904 CDD:275380 4/43 (9%)
leucine-rich repeat 905..926 CDD:275380 6/45 (13%)
leucine-rich repeat 927..950 CDD:275380 4/35 (11%)
leucine-rich repeat 951..974 CDD:275380 5/22 (23%)
leucine-rich repeat 977..1000 CDD:275380 7/23 (30%)
leucine-rich repeat 1001..1024 CDD:275380 5/22 (23%)
leucine-rich repeat 1067..1112 CDD:275380 10/50 (20%)
PP2Cc 1151..1403 CDD:214625
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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