DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment f-cup and lrrc8c

DIOPT Version :9

Sequence 1:	NP_001262544.1	Gene:	f-cup / 41677	FlyBaseID:	FBgn0028487	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_001313473.1	Gene:	lrrc8c / 571216	ZFINID:	ZDB-GENE-030131-2965	Length:	792	Species:	Danio rerio

Alignment Length:	459	Identity:	110/459 - (23%)
Similarity:	185/459 - (40%)	Gaps:	125/459 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 HSPRTNCAFRPIFHERSTHEDDQVLTQELW---KLARKSGTLNLSNK------ALARVPKRLYDI 129
            :.|..:..|.....|.|.::..|:.....|   ||.:|..| |.:|:      .|..:|..::::
Zfish   369 YDPLYSKRFAVFLSEVSENKLKQLNLNHEWTADKLRQKLQT-NSNNRLELQLFMLYGLPDTIFEV 432

  Fly   130 NEADADSKAVNLEQLTIKEEDAWWNQVPLNNLDLSSNTLTHISPKIENLQSLTV----LTLHDNA 190
            .|         |:.|.::         .:||:     |:.....::|:||.|::    |.:|..|
Zfish   433 TE---------LQSLKLE---------IINNV-----TIPAAIAQLEDLQELSLYQCSLKIHSAA 474

  Fly   191 LVELPPEIGKLEKLVRLNVSHNKLSQLPRAMYSLPELRHL------------NISYNEFVELNP- 242
            ...|.      |.|..|.|..:...:||:.:|.|..|..|            |::.:...||..
Zfish   475 TSFLK------ENLKVLRVKFDDSRELPQWLYVLRNLEELHLIGSLGSDAAKNVTLDSLRELKAL 533

  Fly   243 -----------------DI-SDLHMLEFLDGGH-----NNIQSLPGGIGFLVRLTALLLPYNHIK 284
                             |: |.|..|...:.|.     ||::.:.       .||.|.|.:..::
Zfish   534 KTLTLKSNFTKIPQSIVDVASHLQRLSICNDGTKLVMLNNLKKMG-------NLTELELVHCDLE 591

  Fly   285 ELPPDLVNMRSLQKIDLMHNDLTSLPEDMGL--LRKLDCLYLQHNDILELPE-FEGNEALNELHA 346
            .:|..:.::.:||.:||..|:|.|:.|.:..  ||||.||.|.||.|..:|| .:...:|..|:.
Zfish   592 RIPHAIFSLTNLQMLDLKENNLRSIEEILSFQHLRKLTCLKLWHNGIAFIPEHIKKLGSLERLYL 656

  Fly   347 SNNFIKIIPK--AMCSNLPHLKIL--DLR------------------DNKITELPDELCLLRNLN 389
            |:|.|:|:|.  .:|:.|.:|.:.  |:|                  .|||..:||||...:.|.
Zfish   657 SHNKIEILPSHLFLCNKLRYLDVSNNDIRFIPPEIGVLQSLQYFSVSCNKIENIPDELFFCKKLK 721

  Fly   390 RLDVSNNTISVLPVTLSSLAHLISLQVEGNPIKTIRRDILQCGTTRILKTLHDRAVAKAKEEGGG 454
            .|.:..|.:|||...:|.|:.|..|:::||..:.:..::..|              ...|..|..
Zfish   722 TLKLGRNMLSVLSPKISFLSVLTHLELKGNHFEILPAELGAC--------------CALKRSGLA 772

  Fly   455 VDDA 458
            |:||
Zfish   773 VEDA 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
f-cup	NP_001262544.1	leucine-rich repeat	111..140	CDD:275380	6/34 (18%)
		LRR_RI	155..>377	CDD:238064	71/286 (25%)
		leucine-rich repeat	158..180	CDD:275380	5/21 (24%)
		LRR_8	180..235	CDD:290566	16/70 (23%)
		leucine-rich repeat	181..203	CDD:275380	5/25 (20%)
		leucine-rich repeat	204..226	CDD:275380	7/21 (33%)
		LRR_8	225..283	CDD:290566	16/93 (17%)
		leucine-rich repeat	227..249	CDD:275380	8/52 (15%)
		leucine-rich repeat	250..272	CDD:275380	4/26 (15%)
		LRR_8	272..329	CDD:290566	22/58 (38%)
		leucine-rich repeat	273..295	CDD:275380	5/21 (24%)
		leucine-rich repeat	296..318	CDD:275380	9/23 (39%)
		LRR_8	317..375	CDD:290566	24/80 (30%)
		leucine-rich repeat	319..340	CDD:275380	9/21 (43%)
		leucine-rich repeat	341..364	CDD:275380	9/24 (38%)
		leucine-rich repeat	389..410	CDD:275380	7/20 (35%)
		leucine-rich repeat	411..430	CDD:275380	4/18 (22%)
		leucine-rich repeat	627..650	CDD:275380
		leucine-rich repeat	651..669	CDD:275380
		leucine-rich repeat	697..719	CDD:275380
		LRR_8	719..777	CDD:290566
		leucine-rich repeat	720..743	CDD:275380
		leucine-rich repeat	744..766	CDD:275380
lrrc8c	NP_001313473.1	Pannexin_like	1..326	CDD:289311
		leucine-rich repeat	435..457	CDD:275380	5/35 (14%)
		leucine-rich repeat	458..481	CDD:275380	7/28 (25%)
		LRR_RI	476..684	CDD:238064	56/220 (25%)
		leucine-rich repeat	482..501	CDD:275380	5/18 (28%)
		leucine-rich repeat	505..532	CDD:275380	5/26 (19%)
		leucine-rich repeat	533..555	CDD:275380	1/21 (5%)
		leucine-rich repeat	556..579	CDD:275380	5/29 (17%)
		LRR_8	579..638	CDD:290566	22/58 (38%)
		leucine-rich repeat	580..602	CDD:275380	5/21 (24%)
		leucine-rich repeat	603..627	CDD:275380	9/23 (39%)
		LRR_8	626..684	CDD:290566	21/57 (37%)
		leucine-rich repeat	628..650	CDD:275380	9/21 (43%)
		leucine-rich repeat	651..673	CDD:275380	8/21 (38%)
		leucine-rich repeat	674..696	CDD:275380	4/21 (19%)
		LRR_8	696..753	CDD:290566	19/56 (34%)
		leucine-rich repeat	697..719	CDD:275380	7/21 (33%)
		leucine-rich repeat	720..742	CDD:275380	8/21 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910