DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment f-cup and lrrc8db

DIOPT Version :9

Sequence 1:	NP_001262544.1	Gene:	f-cup / 41677	FlyBaseID:	FBgn0028487	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_001070848.1	Gene:	lrrc8db / 563923	ZFINID:	ZDB-GENE-061013-487	Length:	841	Species:	Danio rerio

Alignment Length:	458	Identity:	108/458 - (23%)
Similarity:	196/458 - (42%)	Gaps:	96/458 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 QASVVHSPRTNCAFRPIFHERSTHEDDQVLTQELW---KLARKSGTLNLSNK------ALARVPK 124
            |...::|.|    |.....|.|.::..::.....|   || |:..|.|..:|      .|:.||.
Zfish   408 QYDQLYSKR----FGVFLSEVSENKLREISLNHEWTFEKL-RQHVTRNAQDKLELHLFMLSGVPD 467

  Fly   125 RLYDINEADADSKAVNLEQLTIKEEDAWWNQVPLNNLDLSSNTLTHISPKIENL------QSLTV 183
            .::|:    .|.:.:.||.:......|..:|:    ::|:.....|...|:|..      ..|..
Zfish   468 AVFDL----TDIEVLKLELIPEARITAKISQM----INLTELHFYHCPAKVEQTAFSFLRDHLRC 524

  Fly   184 LTLHDNALVELPPEIGKLEKL------VRLNVSHNKLSQLPRAMYSLPELRHLNISY--NEFVEL 240
            |.:....:.|:|..:..|:.|      ..||..:||:..|.    ||.:||||.:.:  :...::
Zfish   525 LHVKFTDVAEIPTWVYMLKNLRELYLVGNLNSENNKMIGLE----SLRDLRHLKVLHLKSNLTKI 585

  Fly   241 NPDISDL--HMLEFLDGGHNN------IQSLPGGIGFLVRLTALLLPYNHIKELPPDLVNMRSLQ 297
            ..:|:||  |:::.:  .||:      :.||..    ::.|:.|.|....::.:|..:.::.:||
Zfish   586 PTNITDLSPHLIKLV--VHNDGTKLLVLNSLKK----MMNLSDLELHNCELERIPHAIFSLTNLQ 644

  Fly   298 KIDLMHNDLTSLPEDMGL--LRKLDCLYLQHNDILELPEFEGNEALNELHASNNFIKIIPKAMCS 360
            ::||..|::.::.|.:..  |::|:||.|.||.|:.:|       |:..|..|
Zfish   645 ELDLKSNNIRTIEEVISFQHLKRLNCLKLWHNKIISIP-------LSISHVKN------------ 690

  Fly   361 NLPHLKILDLRDNKITELPDELCLLRNLNRLDVSNNTISVLPVTLSSLAHLISLQVEGNPIKTIR 425
                |:.|.|..||:..||..|..|..|..||||:|:|.|:|..:..|.:|....:.||.::.:.
Zfish   691 ----LEFLYLSHNKLESLPTTLFNLLKLRYLDVSHNSIVVIPPEVGFLQNLQHFAITGNKVEVVP 751

  Fly   426 RDILQCGTTRILKTLHDRAVAKAKEEGGGVDDASTSAGISVTRLRGGQMDDGDIPGNFPDSFHHQ 490
            :.:.:|...|.|...|: .::...|:.|.:        :.:|.|        ::.||..|....|
Zfish   752 KQLFKCTKLRTLSLGHN-CISSLPEKIGQL--------LQLTHL--------ELKGNCLDRLPAQ 799

  Fly   491 QQQ 493
            ..|
Zfish   800 LGQ 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
f-cup	NP_001262544.1	leucine-rich repeat	111..140	CDD:275380	8/34 (24%)
		LRR_RI	155..>377	CDD:238064	57/245 (23%)
		leucine-rich repeat	158..180	CDD:275380	4/27 (15%)
		LRR_8	180..235	CDD:290566	17/62 (27%)
		leucine-rich repeat	181..203	CDD:275380	5/21 (24%)
		leucine-rich repeat	204..226	CDD:275380	8/27 (30%)
		LRR_8	225..283	CDD:290566	15/67 (22%)
		leucine-rich repeat	227..249	CDD:275380	7/25 (28%)
		leucine-rich repeat	250..272	CDD:275380	4/27 (15%)
		LRR_8	272..329	CDD:290566	17/58 (29%)
		leucine-rich repeat	273..295	CDD:275380	4/21 (19%)
		leucine-rich repeat	296..318	CDD:275380	7/23 (30%)
		LRR_8	317..375	CDD:290566	15/57 (26%)
		leucine-rich repeat	319..340	CDD:275380	8/20 (40%)
		leucine-rich repeat	341..364	CDD:275380	3/22 (14%)
		leucine-rich repeat	389..410	CDD:275380	9/20 (45%)
		leucine-rich repeat	411..430	CDD:275380	3/18 (17%)
		leucine-rich repeat	627..650	CDD:275380
		leucine-rich repeat	651..669	CDD:275380
		leucine-rich repeat	697..719	CDD:275380
		LRR_8	719..777	CDD:290566
		leucine-rich repeat	720..743	CDD:275380
		leucine-rich repeat	744..766	CDD:275380
lrrc8db	NP_001070848.1	Pannexin_like	1..367	CDD:289311
		leucine-rich repeat	498..521	CDD:275380	4/22 (18%)
		leucine-rich repeat	522..541	CDD:275380	4/18 (22%)
		LRR_RI	<544..821	CDD:238064	77/309 (25%)
		leucine-rich repeat	545..572	CDD:275380	9/30 (30%)
		leucine-rich repeat	573..619	CDD:275380	9/51 (18%)
		leucine-rich repeat	597..611	CDD:275380	2/15 (13%)
		leucine-rich repeat	620..642	CDD:275380	4/21 (19%)
		LRR_8	641..701	CDD:290566	22/82 (27%)
		leucine-rich repeat	643..667	CDD:275380	7/23 (30%)
		leucine-rich repeat	668..690	CDD:275380	10/28 (36%)
		LRR_8	689..747	CDD:290566	23/73 (32%)
		LRR_4	689..729	CDD:289563	18/55 (33%)
		leucine-rich repeat	691..713	CDD:275380	9/21 (43%)
		leucine-rich repeat	714..736	CDD:275380	10/21 (48%)
		LRR_8	736..791	CDD:290566	11/71 (15%)
		leucine-rich repeat	737..759	CDD:275380	4/21 (19%)
		leucine-rich repeat	760..782	CDD:275380	5/30 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910