DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment f-cup and scrib

DIOPT Version :10

Sequence 1:NP_001262544.1 Gene:f-cup / 41677 FlyBaseID:FBgn0028487 Length:802 Species:Drosophila melanogaster
Sequence 2:NP_001163746.1 Gene:scrib / 44448 FlyBaseID:FBgn0263289 Length:2585 Species:Drosophila melanogaster


Alignment Length:972 Identity:207/972 - (21%)
Similarity:329/972 - (33%) Gaps:382/972 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   112 LNLSNKALARVPKRLYDINEADADSKAVNLEQLTIKEEDAWWNQVP-----------LNNLDLSS 165
            |.||:..:.|:|.   ||.         |.|.|.  |.|...|.:|           |...|.||
  Fly    65 LGLSDNEIGRLPP---DIQ---------NFENLV--ELDVSRNDIPDIPDDIKHLQSLQVADFSS 115

  Fly   166 NTLTHISPKIENLQSLTVLTLHDNALVELPPEIGKLEKLVRLNVSHNKLSQLPRAMYSLPELRHL 230
            |.:..:......|::||||.|:|.:|..||.:.|.|.:|..|.:..|.|..||..:..|.:|:.|
  Fly   116 NPIPKLPSGFSQLKNLTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRL 180

  Fly   231 NISYNEFVELNPDIS---DLHMLEFLDGGHNNIQSLPGGIGFLVRLTALLLPYNHIKELPPDLVN 292
            ::..||..:|.|.:.   .||.| :||  ||.:|.||..:|.|.:||.|.:..|.::|||.::..
  Fly   181 DLGDNEIEDLPPYLGYLPGLHEL-WLD--HNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISG 242

  Fly   293 MRSLQKIDLMHNDLTSLPEDMGLLRKLDCLYLQHNDILELPEFEGN-EALNELHASNNFIKIIPK 356
            :.||..:||..|.|.:||:.:..|.:|..|.|..|.:..|.:..|| |.:.||..:.||:..:|.
  Fly   243 LVSLTDLDLAQNLLEALPDGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPA 307

  Fly   357 AM-------------------------CSNLPHLKILDLRDNKITELPDELCLLRNLNRLDVSNN 396
            ::                         |:|   |.:|.|||||:.:||.||.....|:.||||.|
  Fly   308 SIGQMTKLNNLNVDRNALEYLPLEIGQCAN---LGVLSLRDNKLKKLPPELGNCTVLHVLDVSGN 369

  Fly   397 TISVLPVTLSSLAHLISLQV--------EGNPIKTIRRD--------ILQC-------------- 431
            .:..||.:      |::||:        :..|:.|.:.|        :|.|              
  Fly   370 QLLYLPYS------LVNLQLKAVWLSENQSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPITPA 428

  Fly   432 ----------------------------------------------------------------- 431
                                                                             
  Fly   429 RDLESDSEPFEEREPSRTVVKFSEEATQEKETPFVRQNTPHPKDLKAKAQKLKVERSRNEEHANL 493

  Fly   432 -------GT--------TRILKTLHDR----------------------------AVAKAKEEGG 453
                   ||        ||.:...|.:                            .||....:||
  Fly   494 VTLPEENGTKLAETPTETRTIANNHQQQPHPVQQPIVGVNSKQPVVVGVVTPTTTTVAPTGVQGG 558

  Fly   454 GVDDASTSAGIS------VTRLR---GG--QMDDGDIPGNFPDSFHHQQQQNGFQCPCSYPCQQQ 507
            ....:||:..:.      |..|.   ||  ::.|.|            :|::.|:.......|.:
  Fly   559 SEGASSTANNVKAATAAVVAELAATVGGSDEVQDDD------------EQEDEFESDRRVGFQVE 611

  Fly   508 QMQQQFCVYEP----------LRNCQEY---DRQTQGRI------YEPENYQQQHQ-NGSLRSLF 552
            .....|....|          |:|.:..   |:|....:      .|..:...||. :|.:.|..
  Fly   612 GEDDDFYKRPPKLHRRDTPHHLKNKRVQHLTDKQASEILANALASQERNDTTPQHSLSGKVTSPI 676

  Fly   553 VQQQQQRMEYPYPGYFMYQQQQQQQFSYEQ---------------DPSSRSAVHPRWV--YKLRH 600
            .:::|..:|       ..|||||||..::.               ||.:...|....:  |::..
  Fly   677 EEEEQLEVE-------QEQQQQQQQHPFDSSLSPISAGKTAEASTDPDNLDGVTELRLEQYEIHI 734

  Fly   601 TRTLA---------------------VNLEELT----------SVPDQVFQIARDEGVHVVDFAR 634
            .||.|                     :.:..:|          .|.|:|.::   .|:.|||...
  Fly   735 ERTAAGLGLSIAGGKGSTPFKGDDDGIFISRVTEAGPADLAGLKVGDKVIKV---NGIVVVDADH 796

  Fly   635 NQLSTLPNGLQHMKDLVTELVL-----SNNVIGYVPQFISQFTRISFLNLSNN-LLNDLPTEFGV 693
            .|      .:|.:|.....|||     ...:||: |.| |:...:|.:::... |:.|.|.    
  Fly   797 YQ------AVQVLKACGAVLVLVVQREVTRLIGH-PVF-SEDGSVSQISVETRPLVADAPP---- 849

  Fly   694 LNTLRELNIANNRFPCIPNCVYELQGLEILIASENHIKMLNVSGLQNMRRLSTLDLRNNDIETVP 758
                 ..:|::.|:...|        :|| :..:.|::                ..:...|:.|.
  Fly   850 -----AASISHERYIPAP--------IEI-VPQQQHLQ----------------QQQQQPIQQVA 884

  Fly   759 PILGNLTNITHLELVGNPFRQPR-------------HQILMKGTDAIMSY-------LRDRI 800
            |        || ...||.|..|.             :.:|:.|.:|.:||       :||:|
  Fly   885 P--------TH-SYSGNVFATPTAAQTVQPAVSAAPNGLLLNGREAPLSYIQLHTTLIRDQI 937

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
f-cupNP_001262544.1 LRR 98..428 CDD:443914 112/371 (30%)
leucine-rich repeat 111..140 CDD:275380 7/27 (26%)
leucine-rich repeat 158..180 CDD:275380 6/21 (29%)
leucine-rich repeat 181..203 CDD:275380 11/21 (52%)
leucine-rich repeat 204..226 CDD:275380 7/21 (33%)
leucine-rich repeat 227..249 CDD:275380 7/24 (29%)
leucine-rich repeat 250..272 CDD:275380 10/21 (48%)
leucine-rich repeat 273..295 CDD:275380 7/21 (33%)
leucine-rich repeat 296..318 CDD:275380 8/21 (38%)
leucine-rich repeat 319..340 CDD:275380 7/21 (33%)
leucine-rich repeat 341..364 CDD:275380 7/47 (15%)
leucine-rich repeat 389..410 CDD:275380 7/20 (35%)
leucine-rich repeat 411..430 CDD:275380 6/34 (18%)
leucine-rich repeat 627..650 CDD:275380 6/22 (27%)
LRR <629..>778 CDD:443914 31/154 (20%)
leucine-rich repeat 651..669 CDD:275380 7/22 (32%)
leucine-rich repeat 697..719 CDD:275380 3/21 (14%)
leucine-rich repeat 720..743 CDD:275380 3/22 (14%)
leucine-rich repeat 744..766 CDD:275380 3/21 (14%)
scribNP_001163746.1 leucine-rich repeat 18..38 CDD:275380
LRR_8 37..95 CDD:404697 13/43 (30%)
leucine-rich repeat 39..61 CDD:275380
leucine-rich repeat 62..84 CDD:275380 8/30 (27%)
LRR 67..408 CDD:443914 111/366 (30%)
leucine-rich repeat 85..107 CDD:275380 5/23 (22%)
leucine-rich repeat 108..130 CDD:275380 6/21 (29%)
leucine-rich repeat 131..153 CDD:275380 11/21 (52%)
leucine-rich repeat 154..176 CDD:275380 7/21 (33%)
leucine-rich repeat 177..199 CDD:275380 6/21 (29%)
leucine-rich repeat 200..222 CDD:275380 12/24 (50%)
leucine-rich repeat 223..245 CDD:275380 7/21 (33%)
leucine-rich repeat 269..289 CDD:275380 6/19 (32%)
leucine-rich repeat 292..314 CDD:275380 5/21 (24%)
leucine-rich repeat 315..337 CDD:275380 1/21 (5%)
leucine-rich repeat 361..382 CDD:275380 9/26 (35%)
PDZ1_Scribble-like 730..816 CDD:467188 18/94 (19%)
PDZ2_Scribble-like 927..1019 CDD:467187 3/11 (27%)
PDZ3_Scribble-like 1238..1327 CDD:467186
PDZ4_Scribble-like 1331..1428 CDD:467185
Blue background indicates that the domain is not in the aligned region.

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