DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment f-cup and Lrrc8b

DIOPT Version :9

Sequence 1:	NP_001262544.1	Gene:	f-cup / 41677	FlyBaseID:	FBgn0028487	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_001028722.1	Gene:	Lrrc8b / 433926	MGIID:	2141353	Length:	803	Species:	Mus musculus

Alignment Length:	338	Identity:	94/338 - (27%)
Similarity:	153/338 - (45%)	Gaps:	62/338 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 RPIFHERSTHE---DDQVLTQELWKLARKSGTLNLSN-------KALARVPKRLYDINEADADSK 137
            |.:||.::..|   ...||.::|..| ...|..:|.|       .:|:|:|:.:.|:
Mouse   504 RWVFHLKNLKELYLSGCVLPEQLSSL-HLEGFQDLKNLRTLYLKSSLSRIPQVVTDL-------- 559

  Fly   138 AVNLEQLTIKEEDAWWNQVPLNNLDLSSNTLTHISPKIENLQSLTVLTLHDNALVELPPEIGKLE 202
            ..:|::|::..|.:  ..|.||||           .|:.||:||.:|:..   |..:|..|..|.
Mouse   560 LPSLQKLSLDNEGS--KLVVLNNL-----------KKMVNLKSLELLSCD---LERIPHSIFSLN 608

  Fly   203 KLVRLNVSHNKLSQLPR--AMYSLPELRHLNISYNEFVELNPDISDLHMLEFLDGGHNNIQSLPG 265
            .|..|::..|.|..:..  :...||.|..|.:.:|....:...|..|..||.|..|||||:|||.
Mouse   609 NLHELDLKENNLKTVEEIISFQHLPSLSCLKLWHNNIAYIPAQIGALSNLEQLFLGHNNIESLPL 673

  Fly   266 GIGFLVRLTALLLPYNHIKELPPDLVNMRSLQKIDLMHNDLTSLPEDMGLLRKLDCLYLQHNDIL 330
            .:....:|..|.|.|||:..:|.::..:.:||...:.:|::..||:.:...:||.||.|..|.:.
Mouse   674 QLFLCTKLHYLDLSYNHLTFIPEEIQYLTNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGRNSLT 738

  Fly   331 ELPEFEGNEALNELHASNNFIKIIPKAMCSNLPHLKILDLRDNKITELPDELCLLRNLNR--LDV 393
            :|....|     ||               |||.|   |:|..|.:..||.||...::|.|  |.|
Mouse   739 DLSPLVG-----EL---------------SNLTH---LELTGNYLETLPVELEGCQSLKRSCLIV 780

  Fly   394 SNNTISVLPVTLS 406
            .::.::.||:.::
Mouse   781 EDSLLNSLPLPVA 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
f-cup	NP_001262544.1	leucine-rich repeat	111..140	CDD:275380	6/35 (17%)
		LRR_RI	155..>377	CDD:238064	66/223 (30%)
		leucine-rich repeat	158..180	CDD:275380	7/21 (33%)
		LRR_8	180..235	CDD:290566	15/56 (27%)
		leucine-rich repeat	181..203	CDD:275380	6/21 (29%)
		leucine-rich repeat	204..226	CDD:275380	5/23 (22%)
		LRR_8	225..283	CDD:290566	22/57 (39%)
		leucine-rich repeat	227..249	CDD:275380	5/21 (24%)
		leucine-rich repeat	250..272	CDD:275380	11/21 (52%)
		LRR_8	272..329	CDD:290566	18/56 (32%)
		leucine-rich repeat	273..295	CDD:275380	7/21 (33%)
		leucine-rich repeat	296..318	CDD:275380	5/21 (24%)
		LRR_8	317..375	CDD:290566	17/57 (30%)
		leucine-rich repeat	319..340	CDD:275380	7/20 (35%)
		leucine-rich repeat	341..364	CDD:275380	5/22 (23%)
		leucine-rich repeat	389..410	CDD:275380	5/20 (25%)
		leucine-rich repeat	411..430	CDD:275380
		leucine-rich repeat	627..650	CDD:275380
		leucine-rich repeat	651..669	CDD:275380
		leucine-rich repeat	697..719	CDD:275380
		LRR_8	719..777	CDD:290566
		leucine-rich repeat	720..743	CDD:275380
		leucine-rich repeat	744..766	CDD:275380
Lrrc8b	NP_001028722.1	Pannexin_like	1..334	CDD:372171
		LRR 1	415..439
		PLN00113	<428..>692	CDD:215061	61/212 (29%)
		LRR 2	440..462
		LRR 3	464..486
		leucine-rich repeat	465..488	CDD:275380
		LRR 4	488..509		2/4 (50%)
		leucine-rich repeat	489..511	CDD:275380	3/6 (50%)
		LRR 5	511..532		5/21 (24%)
		leucine-rich repeat	512..539	CDD:275380	7/27 (26%)
		LRR 6	539..559		4/19 (21%)
		leucine-rich repeat	540..562	CDD:275380	4/29 (14%)
		LRR 7	562..582		8/32 (25%)
		leucine-rich repeat	563..586	CDD:275380	9/35 (26%)
		LRR	<578..794	CDD:227223	75/253 (30%)
		LRR 8	586..607		8/23 (35%)
		leucine-rich repeat	587..609	CDD:275380	8/24 (33%)
		LRR 9	609..630		4/20 (20%)
		leucine-rich repeat	610..634	CDD:275380	5/23 (22%)
		LRR 10	634..655		4/20 (20%)
		leucine-rich repeat	635..657	CDD:275380	5/21 (24%)
		LRR 11	657..678		11/20 (55%)
		leucine-rich repeat	658..680	CDD:275380	11/21 (52%)
		LRR 12	680..701		7/20 (35%)
		LRR 13	703..724		5/20 (25%)
		leucine-rich repeat	704..726	CDD:275380	5/21 (24%)
		LRR 14	726..747		8/25 (32%)
		leucine-rich repeat	727..749	CDD:275380	9/41 (22%)
		LRR 15	749..771		10/24 (42%)
		leucine-rich repeat	750..772	CDD:275380	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000