DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment f-cup and CG10307

DIOPT Version :9

Sequence 1:	NP_001262544.1	Gene:	f-cup / 41677	FlyBaseID:	FBgn0028487	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_001286690.1	Gene:	CG10307 / 37477	FlyBaseID:	FBgn0034655	Length:	341	Species:	Drosophila melanogaster

Alignment Length:	358	Identity:	92/358 - (25%)
Similarity:	145/358 - (40%)	Gaps:	70/358 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 EDAWWNQVPLNNLDLSSNTLTHISPKIENLQSLTVLTLHDNALVELPPEIGKLEKLVRLNVSHNK 213
            |||.:.:.  .:|:||...::.:...||..::|..|.|:.|.|.::|..||.|.:|..|.:.:||
  Fly    18 EDAIYKKA--FSLNLSHYQISDVPGIIEKCETLMKLFLNQNKLTKIPSSIGSLMRLQVLTLDYNK 80

  Fly   214 LSQLPRAMYSLPELRHLNISYNEFVELNPDISDLHMLEFLDGGHNNIQSLPGGIGFLVRLTALLL 278
            |.:.|..:..|..|:.||||.                       |||.|||..:|:|.:|.....
  Fly    81 LDEFPLCICRLVRLKFLNISC-----------------------NNISSLPPELGYLTQLETFWC 122

  Fly   279 PYNHIKELPPDLVNMRSLQKIDLMHNDLTSLPEDMGLLRKLDCLYLQHNDILELPEFEGNEALNE 343
            ....:.|||.::.|...|:.:.:..|.|..||:.:|.|..|..|..:..::.|:|
  Fly   123 NNTGLLELPNEIRNCEHLETLGVRGNPLKKLPDAIGALSSLRWLTAEGCELSEVP---------- 177

  Fly   344 LHASNNFIKIIPKAMCSNLPHLKILDLRDNKITELPDELCLLRNLNRLDVSNNTISVLPV--TLS 406
                      :..|:..||.|   |:|:.|::..||..|..::.|....::.|.|..:|.  .|.
  Fly   178 ----------LTMALLGNLVH---LNLKGNRLRRLPRMLMAMQKLRFAFLNENCIDEMPTRSQLE 229

  Fly   407 SLAHLISLQVEGNPIKTIRRDI-------------LQCGTTRILKTLHDRAVAKAKEE------G 452
            .|..|..|.:..||| ::.||:             |......|...|..||...|:|:      |
  Fly   230 ELRTLHMLNLSKNPI-SLHRDLQLMALRQTNLYVELPSDPANICDGLASRASLNAQEQQEDQARG 293

  Fly   453 GGVDDASTSAGISVTRLRGGQMDDGDIPGNFPD 485
            .|.|..|:....||........|:..:..|..|
  Fly   294 AGQDLDSSDWANSVRTSELDTTDESALENNIED 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
f-cup	NP_001262544.1	leucine-rich repeat	111..140	CDD:275380
		LRR_RI	155..>377	CDD:238064	57/221 (26%)
		leucine-rich repeat	158..180	CDD:275380	5/21 (24%)
		LRR_8	180..235	CDD:290566	21/54 (39%)
		leucine-rich repeat	181..203	CDD:275380	9/21 (43%)
		leucine-rich repeat	204..226	CDD:275380	7/21 (33%)
		LRR_8	225..283	CDD:290566	14/57 (25%)
		leucine-rich repeat	227..249	CDD:275380	5/21 (24%)
		leucine-rich repeat	250..272	CDD:275380	8/21 (38%)
		LRR_8	272..329	CDD:290566	14/56 (25%)
		leucine-rich repeat	273..295	CDD:275380	5/21 (24%)
		leucine-rich repeat	296..318	CDD:275380	7/21 (33%)
		LRR_8	317..375	CDD:290566	11/57 (19%)
		leucine-rich repeat	319..340	CDD:275380	4/20 (20%)
		leucine-rich repeat	341..364	CDD:275380	3/22 (14%)
		leucine-rich repeat	389..410	CDD:275380	5/22 (23%)
		leucine-rich repeat	411..430	CDD:275380	7/31 (23%)
		leucine-rich repeat	627..650	CDD:275380
		leucine-rich repeat	651..669	CDD:275380
		leucine-rich repeat	697..719	CDD:275380
		LRR_8	719..777	CDD:290566
		leucine-rich repeat	720..743	CDD:275380
		leucine-rich repeat	744..766	CDD:275380
CG10307	NP_001286690.1	leucine-rich repeat	27..44	CDD:275380	4/16 (25%)
		LRR_8	47..104	CDD:290566	22/79 (28%)
		leucine-rich repeat	48..70	CDD:275380	9/21 (43%)
		LRR	69..>244	CDD:227223	55/220 (25%)
		leucine-rich repeat	71..93	CDD:275380	7/21 (33%)
		leucine-rich repeat	94..116	CDD:275380	13/44 (30%)
		leucine-rich repeat	117..139	CDD:275380	5/21 (24%)
		leucine-rich repeat	140..162	CDD:275380	7/21 (33%)
		leucine-rich repeat	163..185	CDD:275380	5/41 (12%)
		leucine-rich repeat	186..208	CDD:275380	8/24 (33%)
		leucine-rich repeat	209..233	CDD:275380	6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467263
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45752
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940