Protein Alignment f-cup and Phlpp

DIOPT Version :10

• Sequence 1: NP_001262544.1
• Gene: f-cup / 41677
• FlyBaseID: FBgn0028487
• Length: 802
• Species: Drosophila melanogaster
• Sequence 2: NP_609938.1
• Gene: Phlpp / 35178
• FlyBaseID: FBgn0032749
• Length: 954
• Species: Drosophila melanogaster
• Alignment Length: 716
• Identity: 171/716 - (23%)
• Similarity: 268/716 - (37%)
• Gaps: 213/716 - (29%)

  Fly    47 KTGRGRSNPSTSRIPRSAQSPRQASVVHS-PRTNCAFRPIFHERSTHEDDQVLT------QEL-W 103
            |..|.:::|..|::..||.        || |      .|:..|.:..|::|..|      |:| .
  Fly     3 KATRKQADPYKSKLKVSAS--------HSGP------HPLPVEVTAAEEEQAATFGQTSPQKLSL 53

  Fly   104 KLARKSGTLNLSNKALARVPKRLYDINEADADSKAVNLEQLTIKEEDAWWNQVPLNNLDLSSNTL 168
            |.::..|::.:.|          |:.           |.||.:.|.:       :..|||||
  Fly    54 KGSQLGGSILIGN----------YNY-----------LTQLEVCENE-------MEVLDLSS--- 87

  Fly   169 THISPKIENLQSLTVLTLHDNALVELPPEIGKLEKLVRLNVSHNKLSQLPRA-MYSLP-ELRHLN 231
                     |..|..|....|.|:||......|:.||   ..||.|..:... .:.:| :|:.::
  Fly    88 ---------LAQLETLKCSRNKLMELIINGTNLQTLV---ADHNYLHNISTTNTHPVPLKLQRID 140

  Fly   232 ISYNEFVELNPDISDLHMLEFLDGGHNNIQSLPGGIGFLVR------LTALLLPYNHIKEL---P 287
            ||:|.|.||...:.....|..::..||.:.:    :..|:|      |.:|.|.||.:|:|   |
  Fly   141 ISHNNFSELPNWVGACASLTAINASHNRLNN----VAVLLRNYRITELVSLDLAYNDLKQLDQFP 201

  Fly   288 PDLVNMRSLQKIDLMHNDLTSLPEDMGLL--RKLDCLYLQHNDILELPEFEGNE----------- 339
            ....::||||   |..|:|.|||::...:  .:|:.|.:..|.:..||.:|.|.
  Fly   202 EGFSSIRSLQ---LQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAG 263

  Fly   340 ---------------ALNELHASNNFIKIIPKAMCSNLPHLKILDLRDNKITELPDELCLLRNLN 389
                           .|..||.:.|.|.::|.|...|.|.|:||.|..|.:.:||:|:..|..|.
  Fly   264 NHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLR 328

  Fly   390 RLDVSNNTISVLPVTLSSLAHLISLQVEGNPIKTIRRDILQCGTTRILKTLH---------DR-- 443
            .|...||.:...| .|:.||.|..|.:..|.:.  |.::|....:|.||.|.         |.
  Fly   329 VLRCCNNLLLCTP-QLAKLAMLKVLDLSHNHLD--RVNLLALVPSRNLKYLDLSGNLQLQVDEQQ 390

  Fly   444 ---AVAKAKEEGGGVD-DASTSAGISVTRLRGGQMDDGDIPGNFPDSFHHQQQQN--------GF 496
               ..::::.....|| ..:..|.:..|::|               ....|:.||        ||
  Fly   391 FKVCQSQSQRHWSLVDVSGNNRAALPTTKIR---------------QVSAQRNQNKTSGPWTMGF 440

  Fly   497 -QCPCSYPCQQQQMQQQFCVYEPLR--NCQEYDRQTQGRIYEPENYQQQHQNGS-LRSLFVQQQQ 557
             :.|.|..|::..:.|       ||  |....|....|.....|...:..|..| |....::|:|
  Fly   441 AETPGSGDCRKLSVYQ-------LRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQEQ 498

  Fly   558 QRMEYPYPGYFMYQQQQQQQFSYEQDPSSRSA-------------VHP----RWVYKLRHTRTLA 605
            ...:.....|..:.....||    |..|.|||             |.|    |:|.::..|..|.
  Fly   499 MVKDSAVRDYMKFTLLAAQQ----QCGSVRSAALFHLTRTRAPSKVRPLKSKRYVLRMASTGGLD 559

  Fly   606 VNLEELTS-----VPDQVFQIARDEGVHVVDFARNQLSTLPNGLQHMKDLVTELVLSNN----VI 661
            ..|...||     .||.:              .::|:.::|:  .|    |.||:|||:    |:
  Fly   560 AYLIRRTSQLRLTKPDVI--------------QKDQIHSMPD--PH----VLELILSNDDEYLVV 604

  Fly   662 G 662
            |
  Fly   605 G 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
f-cup	NP_001262544.1	LRR	98..428	CDD:443914	97/375 (26%)
		leucine-rich repeat	111..140	CDD:275380	2/28 (7%)
		leucine-rich repeat	158..180	CDD:275380	6/21 (29%)
		leucine-rich repeat	181..203	CDD:275380	7/21 (33%)
		leucine-rich repeat	204..226	CDD:275380	6/23 (26%)
		leucine-rich repeat	227..249	CDD:275380	7/21 (33%)
		leucine-rich repeat	250..272	CDD:275380	4/21 (19%)
		leucine-rich repeat	273..295	CDD:275380	8/24 (33%)
		leucine-rich repeat	296..318	CDD:275380	8/23 (35%)
		leucine-rich repeat	319..340	CDD:275380	7/46 (15%)
		leucine-rich repeat	341..364	CDD:275380	8/22 (36%)
		leucine-rich repeat	389..410	CDD:275380	6/20 (30%)
		leucine-rich repeat	411..430	CDD:275380	4/18 (22%)
		leucine-rich repeat	627..650	CDD:275380	3/22 (14%)
		LRR	<629..>778	CDD:443914	11/38 (29%)
		leucine-rich repeat	651..669	CDD:275380	8/16 (50%)
		leucine-rich repeat	697..719	CDD:275380
		leucine-rich repeat	720..743	CDD:275380
		leucine-rich repeat	744..766	CDD:275380
Phlpp	NP_609938.1	LRR	82..>381	CDD:443914	91/323 (28%)
		leucine-rich repeat	91..110	CDD:275380	6/18 (33%)
		leucine-rich repeat	111..135	CDD:275380	7/26 (27%)
		leucine-rich repeat	136..158	CDD:275380	7/21 (33%)
		leucine-rich repeat	159..183	CDD:275380	5/27 (19%)
		leucine-rich repeat	184..209	CDD:275380	8/24 (33%)
		leucine-rich repeat	210..230	CDD:275380	8/22 (36%)
		leucine-rich repeat	232..255	CDD:275380	7/22 (32%)
		leucine-rich repeat	256..276	CDD:275380	0/19 (0%)
		leucine-rich repeat	280..303	CDD:275380	8/22 (36%)
		leucine-rich repeat	304..348	CDD:275380	16/44 (36%)
		leucine-rich repeat	349..372	CDD:275380	5/24 (21%)
		PP2Cc	461..655	CDD:469621	39/169 (23%)