DRSC/TRiP Functional Genomics Resources

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Protein Alignment f-cup and Lrrc8e

DIOPT Version :9

Sequence 1:NP_001262544.1 Gene:f-cup / 41677 FlyBaseID:FBgn0028487 Length:802 Species:Drosophila melanogaster
Sequence 2:NP_001029311.1 Gene:Lrrc8e / 304203 RGDID:1311979 Length:795 Species:Rattus norvegicus


Alignment Length:255 Identity:75/255 - (29%)
Similarity:117/255 - (45%) Gaps:41/255 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 STHEDDQVL--TQELWKLA--RKSGTLNLSNKALARVPKRLYDINEADADSKAVNLEQLTIKEED 150
            |.|.|...|  ...|.|||  |:   |.|....|.|:|..::.:.                    
  Rat   563 SLHNDGARLLALNSLKKLAVLRE---LELVACGLERIPHAIFSLG-------------------- 604

  Fly   151 AWWNQVPLNNLDLSSNTLTHISP--KIENLQSLTVLTLHDNALVELPPEIGKLEKLVRLNVSHNK 213
                  .|..|||..|.|..|..  ..::.:.|.:|.|..|.:..:|..:.||..|.:|.:||||
  Rat   605 ------ALQELDLKDNHLRSIEEILSFQHCRKLVILRLWHNQIAYVPEHVRKLRSLEQLYLSHNK 663

  Fly   214 LSQLPRAMYSLPELRHLNISYNEFVELNPDISDLHMLEFLDGGHNNIQSLPGGIGFLVRLTALLL 278
            |..||..:.....||.|::|:|....|.|::..|..|:.|...:|.::|||..:.|..:|..|||
  Rat   664 LETLPAQLGQCFGLRLLDVSHNGLRSLPPELGLLQSLQHLALSYNALESLPDELFFCHKLRTLLL 728

  Fly   279 PYNHIKELPPDLVNMRSLQKIDLMHNDLTSLPEDMGLLRKLDCLYLQHNDIL-ELPEFEG 337
            .|||:.:..|.:..:::|.:::|..|.|.:|||::|     ||..|:.:.:| |...:||
  Rat   729 GYNHLTQFSPHVAALQALSRLELKGNRLEALPEELG-----DCKGLKKSGLLVEDTLYEG 783

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
f-cupNP_001262544.1 leucine-rich repeat 111..140 CDD:275380 5/28 (18%)
LRR_RI 155..>377 CDD:238064 61/186 (33%)
leucine-rich repeat 158..180 CDD:275380 7/23 (30%)
LRR_8 180..235 CDD:290566 20/54 (37%)
leucine-rich repeat 181..203 CDD:275380 7/21 (33%)
leucine-rich repeat 204..226 CDD:275380 9/21 (43%)
LRR_8 225..283 CDD:290566 21/57 (37%)
leucine-rich repeat 227..249 CDD:275380 8/21 (38%)
leucine-rich repeat 250..272 CDD:275380 7/21 (33%)
LRR_8 272..329 CDD:290566 19/56 (34%)
leucine-rich repeat 273..295 CDD:275380 8/21 (38%)
leucine-rich repeat 296..318 CDD:275380 8/21 (38%)
LRR_8 317..375 CDD:290566 7/22 (32%)
leucine-rich repeat 319..340 CDD:275380 7/20 (35%)
leucine-rich repeat 341..364 CDD:275380
leucine-rich repeat 389..410 CDD:275380
leucine-rich repeat 411..430 CDD:275380
leucine-rich repeat 627..650 CDD:275380
leucine-rich repeat 651..669 CDD:275380
leucine-rich repeat 697..719 CDD:275380
LRR_8 719..777 CDD:290566
leucine-rich repeat 720..743 CDD:275380
leucine-rich repeat 744..766 CDD:275380
Lrrc8eNP_001029311.1 Pannexin_like 1..330 CDD:289311
leucine-rich repeat 508..532 CDD:275380
LRR_RI 526..790 CDD:238064 75/255 (29%)
LRR 1 535..556
leucine-rich repeat 536..558 CDD:275380
LRR 2 558..578 4/14 (29%)
leucine-rich repeat 559..582 CDD:275380 7/18 (39%)
LRR 3 582..603 6/23 (26%)
LRR_8 583..641 CDD:290566 17/86 (20%)
leucine-rich repeat 583..605 CDD:275380 6/50 (12%)
LRR 4 605..626 7/20 (35%)
leucine-rich repeat 606..630 CDD:275380 7/23 (30%)
LRR_8 629..687 CDD:290566 21/57 (37%)
LRR 5 630..651 5/20 (25%)
leucine-rich repeat 631..653 CDD:275380 7/21 (33%)
LRR 6 653..674 9/20 (45%)
leucine-rich repeat 654..676 CDD:275380 9/21 (43%)
LRR_8 676..733 CDD:290566 21/56 (38%)
LRR 7 676..697 7/20 (35%)
leucine-rich repeat 677..699 CDD:275380 8/21 (38%)
LRR 8 699..720 6/20 (30%)
leucine-rich repeat 700..722 CDD:275380 7/21 (33%)
LRR 9 722..743 8/20 (40%)
leucine-rich repeat 723..745 CDD:275380 8/21 (38%)
LRR 10 745..766 8/25 (32%)
leucine-rich repeat 746..766 CDD:275380 8/24 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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