DRSC/TRiP Functional Genomics Resources

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Protein Alignment f-cup and Lrrc8c

DIOPT Version :9

Sequence 1:NP_001262544.1 Gene:f-cup / 41677 FlyBaseID:FBgn0028487 Length:802 Species:Drosophila melanogaster
Sequence 2:NP_001032256.1 Gene:Lrrc8c / 289443 RGDID:1306585 Length:803 Species:Rattus norvegicus


Alignment Length:457 Identity:107/457 - (23%)
Similarity:187/457 - (40%) Gaps:121/457 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 HSPRTNCAFRPIFHERSTHEDDQVLTQELW---KLARKSGTLNLSNK------ALARVPKRLYDI 129
            :.|..:..|.....|.|.::..|:.....|   ||.:|..| |..|:      .|:.:|..:::|
  Rat   380 YDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKLQT-NAHNRLELPLIMLSGLPDTVFEI 443

  Fly   130 NEADADSKAVNLEQLTIKEEDAWWNQVPLNNLDLSSNTLTHIS-PKIENLQSLTV----LTLHDN 189
            .|         |:.|               .|::..|.:...: .:::|||.|::    :.:|..
  Rat   444 TE---------LQSL---------------KLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSA 484

  Fly   190 ALVELPPEIGKLEKLVRLNVSHNKLSQLPRAMYSLPELRHL--------NISYNEFVELNPDISD 246
            ||..|.      |.|..|:|..:.:.:||..||.|..|..|        :||.|..:|...|:..
  Rat   485 ALSFLK------ENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISKNVTLESLRDLKS 543

  Fly   247 LHMLEFLDGGHNNIQSLP-------------------------GGIGFLVRLTALLLPYNHIKEL 286
            |.:|..    .:|:..:|                         ..:..:..||.|.|.:..::.:
  Rat   544 LKILSI----KSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERI 604

  Fly   287 PPDLVNMRSLQKIDLMHNDLTSLPEDMGL--LRKLDCLYLQHNDILELPE-FEGNEALNELHASN 348
            |..:.::.|||::||..|:|.|:.|.:..  ||||..|.|.:|.|..:|| .:...:|..|..|:
  Rat   605 PHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWYNSIAYIPEHIKKLTSLERLFFSH 669

  Fly   349 NFIKIIPK--AMCSNLPHLKIL--DLR------------------DNKITELPDELCLLRNLNRL 391
            |.::::|.  .:|:.:.:|.:.  |:|                  .||:..|||||...:.|..|
  Rat   670 NKVEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTL 734

  Fly   392 DVSNNTISVLPVTLSSLAHLISLQVEGNPIKTIRRDILQCGTTRILKTLHDRAVAKAKEEGGGVD 456
            .:..|::|||...:.:|..|..|.::||..:.:..::..|           ||:.:|   |..|:
  Rat   735 KIGKNSLSVLSPKIGNLLFLSYLDIKGNHFEVLPPELGDC-----------RALKRA---GLVVE 785

  Fly   457 DA 458
            ||
  Rat   786 DA 787

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
f-cupNP_001262544.1 leucine-rich repeat 111..140 CDD:275380 7/34 (21%)
LRR_RI 155..>377 CDD:238064 65/284 (23%)
leucine-rich repeat 158..180 CDD:275380 4/22 (18%)
LRR_8 180..235 CDD:290566 18/66 (27%)
leucine-rich repeat 181..203 CDD:275380 5/25 (20%)
leucine-rich repeat 204..226 CDD:275380 8/21 (38%)
LRR_8 225..283 CDD:290566 15/90 (17%)
leucine-rich repeat 227..249 CDD:275380 8/29 (28%)
leucine-rich repeat 250..272 CDD:275380 3/46 (7%)
LRR_8 272..329 CDD:290566 21/58 (36%)
leucine-rich repeat 273..295 CDD:275380 5/21 (24%)
leucine-rich repeat 296..318 CDD:275380 9/23 (39%)
LRR_8 317..375 CDD:290566 19/80 (24%)
leucine-rich repeat 319..340 CDD:275380 7/21 (33%)
leucine-rich repeat 341..364 CDD:275380 6/24 (25%)
leucine-rich repeat 389..410 CDD:275380 6/20 (30%)
leucine-rich repeat 411..430 CDD:275380 4/18 (22%)
leucine-rich repeat 627..650 CDD:275380
leucine-rich repeat 651..669 CDD:275380
leucine-rich repeat 697..719 CDD:275380
LRR_8 719..777 CDD:290566
leucine-rich repeat 720..743 CDD:275380
leucine-rich repeat 744..766 CDD:275380
Lrrc8cNP_001032256.1 Pannexin_like 1..338 CDD:289311
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 177..211
LRR 1. /evidence=ECO:0000255 397..420 5/22 (23%)
LRR 2. /evidence=ECO:0000255 421..443 4/21 (19%)
leucine-rich repeat 446..468 CDD:275380 4/36 (11%)
LRR 3. /evidence=ECO:0000255 446..466 4/34 (12%)
LRR 4. /evidence=ECO:0000255 467..488 7/20 (35%)
leucine-rich repeat 469..492 CDD:275380 7/28 (25%)
LRR 5. /evidence=ECO:0000255 490..513 8/28 (29%)
leucine-rich repeat 493..515 CDD:275380 8/21 (38%)
LRR 6. /evidence=ECO:0000255 515..537 5/21 (24%)
leucine-rich repeat 516..543 CDD:275380 7/26 (27%)
LRR 7. /evidence=ECO:0000255 541..563 4/25 (16%)
leucine-rich repeat 544..566 CDD:275380 4/25 (16%)
LRR 8. /evidence=ECO:0000255 565..587 0/21 (0%)
leucine-rich repeat 567..590 CDD:275380 0/22 (0%)
LRR 9. /evidence=ECO:0000255 588..611 5/22 (23%)
LRR_8 589..649 CDD:290566 21/59 (36%)
LRR_RI <590..695 CDD:238064 31/104 (30%)
leucine-rich repeat 591..613 CDD:275380 5/21 (24%)
LRR 10. /evidence=ECO:0000255 613..635 9/21 (43%)
leucine-rich repeat 614..638 CDD:275380 9/23 (39%)
LRR_8 637..695 CDD:290566 16/57 (28%)
LRR 11. /evidence=ECO:0000255 637..659 9/21 (43%)
leucine-rich repeat 639..661 CDD:275380 7/21 (33%)
LRR 12. /evidence=ECO:0000255 660..682 5/21 (24%)
leucine-rich repeat 662..684 CDD:275380 6/21 (29%)
LRR 13. /evidence=ECO:0000255 684..705 3/20 (15%)
LRR 14. /evidence=ECO:0000255 706..728 7/21 (33%)
LRR_8 707..764 CDD:290566 18/56 (32%)
leucine-rich repeat 708..730 CDD:275380 7/21 (33%)
LRR 15. /evidence=ECO:0000255 730..751 6/20 (30%)
leucine-rich repeat 731..752 CDD:275380 6/20 (30%)
LRR 16. /evidence=ECO:0000255 752..774 4/21 (19%)
LRR 17. /evidence=ECO:0000255 776..799 6/15 (40%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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