DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment f-cup and phlp-2

DIOPT Version :9

Sequence 1:	NP_001262544.1	Gene:	f-cup / 41677	FlyBaseID:	FBgn0028487	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_001337270.1	Gene:	phlp-2 / 185690	WormBaseID:	WBGene00009647	Length:	1126	Species:	Caenorhabditis elegans

Alignment Length:	808	Identity:	178/808 - (22%)
Similarity:	288/808 - (35%)	Gaps:	294/808 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 SVVHSPRTNCAFRPIF---------HERSTHEDDQVLTQEL----------WKLAR--------K 108
            |...||    |||.||         ..:||...| :|::|:          |:.||        :
Worm   110 SYTDSP----AFRHIFSFFLGRPRIRAKSTLNLD-ILSEEVVIRKGKLIHTWQNARAVFYNSNIR 169

  Fly   109 SGTLNLSNKALARVPKRLYDINEADADSKAVNLEQLTIKEED--------------AWWNQV--- 156
            ..|.|..::|| ::.....|::|:...      ..|.:|::|              ||..:.
Worm   170 LQTKNNQDEAL-QIRNMKVDVHESKRG------RALRLKDDDVCYLIIFQRPNILEAWLTRAQQV 227

  Fly   157 -PLNNLDLSSNTLTHISPKIENLQS-LTVLTLHDNALVELPPEIGKLEKLVRLNVSHNKLSQLPR 219
             ..|::|.|...||.|..:|.|.:: :.:|.|..|:|:..||    .||           |..|
Worm   228 EKSNHVDASDEQLTLIPEQILNNEARVQILNLRRNSLISRPP----TEK-----------SMAP- 276

  Fly   220 AMYSLPELRHLNISYNEFVELNPDISDLHMLEFLDGGHNNIQSLPGGIGFLVRLTALLLPYNHIK 284
                                          |.::|
Worm   277 ------------------------------LGYID------------------------------ 281

  Fly   285 ELPPDLVNMRSLQKIDLMHNDLTSLPEDMGLLRKLDCLYLQHNDILELPEFEGNEALNELHASNN 349
                ||..:.|||.|||..|.:.|.|..:.|        |.|              |.:|:.|:|
Worm   282 ----DLYRVHSLQVIDLSANQILSFPIQLTL--------LSH--------------LRQLNLSSN 320

  Fly   350 FIKIIPKAMCSNLPHLKILDLRDNKITELPDELCLLRNLNRLDVSNNTISVLPVTLSSLAHLISL 414
            :|..:| :.|||:..|:.|:|.:|::..|||.:..|:||..||:|.|..|.:|..|..|. |...
Worm   321 YISSVP-SECSNMRRLQYLNLSNNQLDTLPDSISELQNLQSLDISFNQFSQIPPCLFHLT-LEMW 383

  Fly   415 QVEGNPIKTIRR-DILQCGTTRILKTLHDRAVAKAKEEGGGVD--DASTSAGISVTRLRGGQMDD 476
            ::.||.|:.|.| ..:|.....:.:.:.|.:.....|....:|  |.|..:.:.:|.||
Worm   384 RLAGNNIEKIDRVGEMQIQKIDLRRNVLDTSFRLDIENITHLDLRDNSMISTVHLTNLR------ 442

  Fly   477 GDIPGNFPDSFHHQQQQNGFQCPCSYPCQQQQMQQQFCVYEPLRNCQEYDRQTQGRIYEPENYQQ 541
                  |....|               |::.|:.......|.|.:           :|...|.
Worm   443 ------FLKVIH---------------CERLQLSSLHLSGESLTH-----------VYADHNL-- 473

  Fly   542 QHQNGSLRSLFVQQQQQRMEYPYPGYFMYQQQQQQQFSYEQDPSSRSAVH----PRWVYKLRHTR 602
                  |.||.|.        |.|     |..|....|:.         |    |.|:....:..
Worm   474 ------LDSLVVM--------PLP-----QNLQTLSLSFN---------HFRNLPDWISDCPNLT 510

  Fly   603 TLAVNLEELTSVPDQVF--QIAR------DEGVHVVDFA-----------RNQLSTLPNGLQHMK 648
            .|..|...|.::|:::|  |..|      :|..|:.||.           :|:||:||.....:.
Worm   511 FLRANNNSLVALPERIFYSQSLRSIFAFINEIEHIPDFGEENCLETLILYKNKLSSLPKHFFSIL 575

  Fly   649 DLVTELVLSNNVIGYVPQFI-SQFTRISFLNLSNNLL--NDLP---------------------- 688
            ..:.:|.:|:|.|..:|.|. |.|.|:..|..:||.|  |.:|
Worm   576 PRLRQLNISSNFIELLPYFDGSSFCRLQILRCANNYLTENSVPVIVNMKHLKIIDLSHNRLNSFD 640

  Fly   689 -TEFGVLNTLRELNIANNRFPCIPNCVYELQGLEILIASENHIKMLNVSGLQNMRRLSTLDLRNN 752
             :....|..|.:||:::||...:.:|:..|..|::|.|..|  ::::|...:...:|.|:|:.:|
Worm   641 DSALSSLELLEDLNLSSNRLTRLADCLALLPCLQVLRAHSN--QLVHVPEFRASNQLHTIDVSSN 703

  Fly   753 DIETVPPILGNL-----TNITHLELVGN 775
            :|.     ||.|     .|:.|.::..|
Worm   704 NIS-----LGTLQFKAPPNLRHFDVTCN 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
f-cup	NP_001262544.1	leucine-rich repeat	111..140	CDD:275380	6/28 (21%)
		LRR_RI	155..>377	CDD:238064	47/226 (21%)
		leucine-rich repeat	158..180	CDD:275380	8/21 (38%)
		LRR_8	180..235	CDD:290566	10/55 (18%)
		leucine-rich repeat	181..203	CDD:275380	6/21 (29%)
		leucine-rich repeat	204..226	CDD:275380	2/21 (10%)
		LRR_8	225..283	CDD:290566	2/57 (4%)
		leucine-rich repeat	227..249	CDD:275380	0/21 (0%)
		leucine-rich repeat	250..272	CDD:275380	2/21 (10%)
		LRR_8	272..329	CDD:290566	14/56 (25%)
		leucine-rich repeat	273..295	CDD:275380	2/21 (10%)
		leucine-rich repeat	296..318	CDD:275380	9/21 (43%)
		LRR_8	317..375	CDD:290566	15/57 (26%)
		leucine-rich repeat	319..340	CDD:275380	2/20 (10%)
		leucine-rich repeat	341..364	CDD:275380	9/22 (41%)
		leucine-rich repeat	389..410	CDD:275380	8/20 (40%)
		leucine-rich repeat	411..430	CDD:275380	6/19 (32%)
		leucine-rich repeat	627..650	CDD:275380	8/33 (24%)
		leucine-rich repeat	651..669	CDD:275380	6/18 (33%)
		leucine-rich repeat	697..719	CDD:275380	7/21 (33%)
		LRR_8	719..777	CDD:290566	16/62 (26%)
		leucine-rich repeat	720..743	CDD:275380	5/22 (23%)
		leucine-rich repeat	744..766	CDD:275380	8/26 (31%)
phlp-2	NP_001337270.1	leucine-rich repeat	232..253	CDD:275380	7/20 (35%)
		leucine-rich repeat	254..288	CDD:275380	14/113 (12%)
		PLN00113	283..>718	CDD:331614	127/533 (24%)
		leucine-rich repeat	289..311	CDD:275380	10/29 (34%)
		leucine-rich repeat	312..334	CDD:275380	9/22 (41%)
		leucine-rich repeat	335..357	CDD:275380	8/21 (38%)
		leucine-rich repeat	358..379	CDD:275380	8/20 (40%)
		leucine-rich repeat	380..440	CDD:275380	12/59 (20%)
		leucine-rich repeat	441..485	CDD:275380	16/102 (16%)
		leucine-rich repeat	486..508	CDD:275380	5/30 (17%)
		leucine-rich repeat	509..534	CDD:275380	6/24 (25%)
		leucine-rich repeat	554..577	CDD:275380	5/22 (23%)
		leucine-rich repeat	578..602	CDD:275380	8/23 (35%)
		leucine-rich repeat	603..625	CDD:275380	6/21 (29%)
		leucine-rich repeat	626..649	CDD:275380	1/22 (5%)
		leucine-rich repeat	650..672	CDD:275380	7/21 (33%)
		leucine-rich repeat	673..694	CDD:275380	5/22 (23%)
		PP2Cc	754..985	CDD:214625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910