DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment f-cup and si:zfos-323e3.4

DIOPT Version :9

Sequence 1:	NP_001262544.1	Gene:	f-cup / 41677	FlyBaseID:	FBgn0028487	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	XP_005168747.1	Gene:	si:zfos-323e3.4 / 100333177	ZFINID:	ZDB-GENE-120215-44	Length:	791	Species:	Danio rerio

Alignment Length:	408	Identity:	101/408 - (24%)
Similarity:	165/408 - (40%)	Gaps:	128/408 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 STSRIPRS-AQSPR--QASVVHSPRTNCAFRP--IFHERSTHEDDQVLTQELWKLARKSGTLNLS 115
            |...||.| .|.|.  :.:::|||   |..:|  :.|.|     ||:   ::.::|.:|..|
Zfish   451 SNITIPSSVTQLPALVELTLIHSP---CRLQPAALGHLR-----DQL---KVLRVATESQEL--- 501

  Fly   116 NKALARVPKRLYDINEADADSKAVNLEQLTIKEEDAWWNQVPLNNLDLSSNTLTHISPKIENLQS 180
                  :|..:|.:.         |||:|.:.           .:|.|.|         :..|::
Zfish   502 ------LPLWMYTLQ---------NLEELHLS-----------GDLTLDS---------LRELKN 531

  Fly   181 LTVLTLHDNALVELPPEI----------------------GKLEKLVR---LNVSHNKLSQLPRA 220
            |.||||... |.::||.:                      ..|:||||   |.::...|.::|.|
Zfish   532 LRVLTLRCK-LTKIPPGVMDVSQQLLRLCVHNEGTRLQAFSSLKKLVRLAALELTGCGLERIPSA 595

  Fly   221 MYSLPELRHLNISYNEFVELNPDISDLH--MLEFLDGGHNNIQSLPGGIGFLVRLTALLLPYNHI 283
            ::||..|:.|::..|..:.:...:|..|  .|..|..|||.|..:|..|..|..|..|.:.:|.:
Zfish   596 VFSLSHLQELDLRENRLMAVEEILSLQHCRRLATLRLGHNRISCIPEHISRLRALETLDVSWNSL 660

  Fly   284 KELPPDLVNMRSLQKIDLMHNDLTSLPEDMGLLRKLDCLYLQHNDILELPEFEGNEALNELHASN 348
            ..|||.|.....|:.:||.||.|.|||.::|:|:
Zfish   661 CRLPPRLCYCPRLRHLDLSHNQLVSLPSEIGVLQ------------------------------- 694

  Fly   349 NFIKIIPKAMCSNLPHLKILDLRDNKITELPDELCLLRNLNRLDVSNNTISVLPVTLSSLAHLIS 413
                           .|:.|.:..|.:..||:||...|.|..|.:.||:|:.|...:.:||.|:.
Zfish   695 ---------------GLQFLSVAFNALESLPEELFSCRRLRVLALGNNSITALSPRVGNLAQLVR 744

  Fly   414 LQVEGNPIKTIRRDILQC 431
            |:::||.::.:..:|..|
Zfish   745 LELKGNRLEGLPVEIADC 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
f-cup	NP_001262544.1	leucine-rich repeat	111..140	CDD:275380	3/28 (11%)
		LRR_RI	155..>377	CDD:238064	58/248 (23%)
		leucine-rich repeat	158..180	CDD:275380	4/21 (19%)
		LRR_8	180..235	CDD:290566	21/79 (27%)
		leucine-rich repeat	181..203	CDD:275380	9/43 (21%)
		leucine-rich repeat	204..226	CDD:275380	9/24 (38%)
		LRR_8	225..283	CDD:290566	17/59 (29%)
		leucine-rich repeat	227..249	CDD:275380	5/23 (22%)
		leucine-rich repeat	250..272	CDD:275380	9/21 (43%)
		LRR_8	272..329	CDD:290566	18/56 (32%)
		leucine-rich repeat	273..295	CDD:275380	7/21 (33%)
		leucine-rich repeat	296..318	CDD:275380	11/21 (52%)
		LRR_8	317..375	CDD:290566	3/57 (5%)
		leucine-rich repeat	319..340	CDD:275380	0/20 (0%)
		leucine-rich repeat	341..364	CDD:275380	0/22 (0%)
		leucine-rich repeat	389..410	CDD:275380	6/20 (30%)
		leucine-rich repeat	411..430	CDD:275380	5/18 (28%)
		leucine-rich repeat	627..650	CDD:275380
		leucine-rich repeat	651..669	CDD:275380
		leucine-rich repeat	697..719	CDD:275380
		LRR_8	719..777	CDD:290566
		leucine-rich repeat	720..743	CDD:275380
		leucine-rich repeat	744..766	CDD:275380
si:zfos-323e3.4	XP_005168747.1	Pannexin_like	1..334	CDD:289311
		leucine-rich repeat	465..488	CDD:275380	7/30 (23%)
		leucine-rich repeat	489..508	CDD:275380	4/30 (13%)
		leucine-rich repeat	512..531	CDD:275380	7/38 (18%)
		leucine-rich repeat	532..575	CDD:275380	9/43 (21%)
		LRR_RI	<573..752	CDD:238064	63/224 (28%)
		leucine-rich repeat	576..601	CDD:275380	9/24 (38%)
		LRR_8	578..637	CDD:290566	17/58 (29%)
		leucine-rich repeat	602..626	CDD:275380	5/23 (22%)
		LRR_8	625..683	CDD:290566	21/57 (37%)
		leucine-rich repeat	627..649	CDD:275380	9/21 (43%)
		leucine-rich repeat	650..672	CDD:275380	7/21 (33%)
		LRR_8	671..752	CDD:290566	31/126 (25%)
		leucine-rich repeat	673..695	CDD:275380	11/67 (16%)
		leucine-rich repeat	696..718	CDD:275380	7/21 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910