DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment flfl and Ppp4r3a

DIOPT Version :9

Sequence 1:	NP_731849.2	Gene:	flfl / 41675	FlyBaseID:	FBgn0024555	Length:	980	Species:	Drosophila melanogaster
Sequence 2:	XP_017170662.1	Gene:	Ppp4r3a / 68734	MGIID:	1915984	Length:	842	Species:	Mus musculus

Alignment Length:	992	Identity:	475/992 - (47%)
Similarity:	642/992 - (64%)	Gaps:	175/992 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TDTRRRVKLYALNAERQWDDRGTGHVSSTYVERLKGISLLVRAESDGSLLLESKIQPDTAYQKQQ 67
            ||||||||:|.||.:|||||||||||||.|||||||:||||||||||||||||||.|:|||||||
Mouse     2 TDTRRRVKVYTLNEDRQWDDRGTGHVSSGYVERLKGMSLLVRAESDGSLLLESKINPNTAYQKQQ 66

  Fly    68 DTLIVWSEGDNFDLALSFQEKAGCDEIWEKICQVQGKDPSVEITQDIVEESEDERFEDMSDTAPP 132
            ||||||||.:|:|||||||||||||||||||||||||||||:||||:|:|||:|||:|||  :|.
Mouse    67 DTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVDITQDLVDESEEERFDDMS--SPG 129

  Fly   133 IELPPCELSRLEDISETIQSCLSTPLRKEKLSMALESESYIKKLLNLFHVCEDLDNTEGLHHLFE 197
            :|||.|||||||:|:|.:.|.|.:|||:|||::|||:|.||||||.||||||||:|.||||||:|
Mouse   130 LELPSCELSRLEEIAELVASSLPSPLRREKLALALENEGYIKKLLELFHVCEDLENIEGLHHLYE 194

  Fly   198 IFKNIFLLNKNALFEIMFADDTIFDVVGCLEYDPSVSQPKKHRQYLKQLAKFREAVPIKNLDLLA 262
            |.|.|||||:.||||:||:::.|.||:|||||||::|||:|||::|.:.|||:|.:||.:.:|..
Mouse   195 IIKGIFLLNRTALFEVMFSEECIMDVIGCLEYDPTLSQPRKHREFLTKTAKFKEVIPISDPELKQ 259

  Fly   263 KIHQTFRVQYIQDIILPTPSVFVEDNMLNTLSSFIFFNKVEIVTMIQDDERYLLDVFAVLTDPTT 327
            |||||:|||||||::||||||| |:|||:||.|||||||||||.|:|:||::|.|:||.|||..|
Mouse   260 KIHQTYRVQYIQDMVLPTPSVF-EENMLSTLHSFIFFNKVEIVGMLQEDEKFLTDLFAQLTDEAT 323

  Fly   328 GDAKRRDTVLFLKEFCNYAQNLQPQGKDSFYKTLTCLGILQALELTLVMNDKKTKSASIDILTAI 392
            .:.||::.|.||||||.::|.||||.:|:|:|||:.:|||.|||:.|.|:|.:.:||:.||.:.:
Mouse   324 DEEKRQELVNFLKEFCAFSQTLQPQNRDAFFKTLSNMGILPALEVILGMDDTQVRSAATDIFSYL 388

  Fly   393 VEFSPLVVRNYTLNQANR-PEVER------------MLLNIAIEQMLNDSEPELGIAVQLMGIVK 444
            ||::|.:||.:.:.:|.: .:|.:            :|:|:.||.|:.|::||||.||||||:::
Mouse   389 VEYNPSMVREFVMQEAQQNDDVSKKLTEQKITSKDILLINLIIEHMICDTDPELGGAVQLMGLLR 453

  Fly   445 ILLEPENML-----TEKGDFLNFFYKYSVQTLVAPVILNTIGDRPQNEDYQTAQLLGIVLDILSF 504
            .|::|||||     |||.:||.||||:.:..|.||::.||..|:|..:|:||||||.:||::|:|
Mouse   454 TLVDPENMLATANKTEKTEFLGFFYKHCMHVLTAPLLANTTEDKPSKDDFQTAQLLALVLELLTF 518

  Fly   505 CVEHHSYHIKNFLLQKDLLKRILVLMKSTHTFLVLGALRLLRKIIALKDEFYNRHIVKCNLFAPV 569
            |||||:|||||:::.||:|:|:||||.|.|.||.|.|||..||||.||||||||:|:|..||.||
Mouse   519 CVEHHTYHIKNYIINKDILRRVLVLMASKHAFLALCALRFKRKIIGLKDEFYNRYIMKSFLFEPV 583

  Fly   570 VDAFIRNNGRYNLLESAILELFEFIKLEDIRTLCVYFVENFSKIFDEIEYVQTFKYLKNRYDQYQ 634
            |.||:.|..||||:.|||:|:||||::|||::|..:.:||:.|..::::||||||.||.|::|.:
Mouse   584 VKAFLNNGSRYNLMNSAIIEMFEFIRVEDIKSLTAHVIENYWKALEDVDYVQTFKGLKLRFEQQR 648

  Fly   635 DRLKDRDKMENRTDGGLPIIRSGGRFRRDQRQMEEEEEMWFNEEDDFTEEIDTYNNVMKSVSEKN 699
            :| :|..|:::...    |:|: .|:|||.|.:|:|||||||.::|..|:    ...:.|.|:|
Mouse   649 ER-QDNPKLDSMRS----ILRN-HRYRRDARTLEDEEEMWFNTDEDDMED----GEAVVSPSDK- 702

  Fly   700 GPQTQNQQKSSPPHSTSPHSGLLGSLSTTASSTATSATSGAPVASGSSSPEAISADEQTQAAVHL 764
               |:|......|.|
Mouse   703 ---TKNDDDIMDPIS-------------------------------------------------- 714

  Fly   765 AAAALQHHQQQQQQQQQNPFQQQTQPEIAELQQQLSSVEAPQSQELELSQSAAASASPTSSSSSL 829
                              .|.::.:   ..|:|:...::..:.:|:.|..:.:...||     |.
Mouse   715 ------------------KFMERKK---CMLKQRAREMKESEEKEVLLKTNLSGRQSP-----SF 753

  Fly   830 EASTSSSSASSSSSSSSSSSPPGSSAAASLCDSATVAAVAASQFLSTIATAMAASVTAAAATNSS 894
            :.|.||.:.::.:|.||::|.|||.                                      .|
Mouse   754 KLSLSSGTKTNLTSQSSATSLPGSP--------------------------------------GS 780

  Fly   895 PSISPAPAVSSPDIENADAQLPPSDDASSPASGEQDAN-STEGTSSEADKTTAKKGLVDYESDSG 958
            |. ||.               .|....|.|.|..|.|. :|:|         ...|||||..|..
Mouse   781 PG-SPG---------------SPGSPGSVPKSTSQTAAITTKG---------GLVGLVDYPDDDE 820

  Fly   959 EDDYEEDEYSEGPQAQK 975
            :||.:||:....|.::|
Mouse   821 DDDEDEDKEDTLPVSKK 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flfl	NP_731849.2	PH-like	8..>66	CDD:302622	49/57 (86%)
flfl	NP_731849.2	SMK-1	169..361	CDD:282636	125/191 (65%)
Ppp4r3a	XP_017170662.1	PH-like	7..>65	CDD:388408	49/57 (86%)
		SMK-1	166..357	CDD:368128	125/191 (65%)
		DUF2052	<626..>741	CDD:370656	42/199 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848894
Domainoid	1	1.000	353	1.000	Domainoid score	I1000
eggNOG	1	0.900	-	-		E1_KOG2175
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	887	1.000	Inparanoid score	I396
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54949
OrthoDB	1	1.010	-	-		D261288at33208
OrthoFinder	1	1.000	-	-		FOG0001376
OrthoInspector	1	1.000	-	-		otm43802
orthoMCL	1	0.900	-	-		OOG6_101106
Panther	1	1.100	-	-	O	PTHR23318
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3995
SonicParanoid	1	1.000	-	-		X869
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.800