DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment flfl and Ppp4r3b

DIOPT Version :9

Sequence 1:	NP_731849.2	Gene:	flfl / 41675	FlyBaseID:	FBgn0024555	Length:	980	Species:	Drosophila melanogaster
Sequence 2:	NP_001101837.1	Gene:	Ppp4r3b / 360993	RGDID:	1309450	Length:	820	Species:	Rattus norvegicus

Alignment Length:	830	Identity:	450/830 - (54%)
Similarity:	602/830 - (72%)	Gaps:	53/830 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TDTRRRVKLYALNAERQWDDRGTGHVSSTYVERLKGISLLVRAESDGSLLLESKIQPDTAYQKQQ 67
            :|||||||:|.||.:|||||||||||||||||.|||:||||||||||||||||||.|:|||||||
  Rat     2 SDTRRRVKVYTLNEDRQWDDRGTGHVSSTYVEELKGMSLLVRAESDGSLLLESKINPNTAYQKQQ 66

  Fly    68 DTLIVWSEGDNFDLALSFQEKAGCDEIWEKICQVQGKDPSVEITQDIVEESEDERFEDMSDTAPP 132
            ||||||||.:|:||||||||||||||||||||||||||||||:|||:::|||:||||:|.:|:..
  Rat    67 DTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVEVTQDLIDESEEERFEEMPETSHL 131

  Fly   133 IELPPCELSRLEDISETIQSCLSTPLRKEKLSMALESESYIKKLLNLFHVCEDLDNTEGLHHLFE 197
            |:||.||||:||:|::.:.|.||:|:|:|||::|||:|.||||||.||..||:|:||||||.|:|
  Rat   132 IDLPTCELSKLEEIADLVTSVLSSPIRREKLALALENEGYIKKLLQLFQACENLENTEGLHQLYE 196

  Fly   198 IFKNIFLLNKNALFEIMFADDTIFDVVGCLEYDPSVSQPKKHRQYLKQLAKFREAVPIKNLDLLA 262
            |.:.|..|||..|||:||:|:.|.||||||||||:::|||:||::|.:.|||:|.:||.:.:|..
  Rat   197 IIRGILFLNKATLFEVMFSDECIMDVVGCLEYDPALAQPKRHREFLTKTAKFKEVIPITDSELRQ 261

  Fly   263 KIHQTFRVQYIQDIILPTPSVFVEDNMLNTLSSFIFFNKVEIVTMIQDDERYLLDVFAVLTDPTT 327
            |||||:|||||||||||||||| |:|.|:||:|||||||||||:|:|:||::|.:|||.|||..|
  Rat   262 KIHQTYRVQYIQDIILPTPSVF-EENFLSTLTSFIFFNKVEIVSMLQEDEKFLSEVFAQLTDEAT 325

  Fly   328 GDAKRRDTVLFLKEFCNYAQNLQPQGKDSFYKTLTCLGILQALELTLVMNDKKTKSASIDILTAI 392
            .|.|||:.|.|.||||.::|.||||.:|:|:|||..||||.|||:.:.|:|.:.:||:.||.:.:
  Rat   326 DDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTLAKLGILPALEIVMGMDDLQVRSAATDIFSYL 390

  Fly   393 VEFSPLVVRNYTLNQANRPEVERMLLNIAIEQMLNDSEPELGIAVQLMGIVKILLEPENML---- 453
            |||||.:||.:.:.:|.:.:.:.:|:|:.||||:.|::||||.||||||:::.|::|||||
  Rat   391 VEFSPSMVREFVMQEAQQSDDDILLINVVIEQMICDTDPELGGAVQLMGLLRTLIDPENMLATTN 455

  Fly   454 -TEKGDFLNFFYKYSVQTLVAPVILNTIGDRPQN--------------EDYQTAQLLGIVLDILS 503
             |||.:||||||.:.:..|.||::.||..|:.:.              ::|||||||.::|::|:
  Rat   456 KTEKSEFLNFFYNHCMHVLTAPLLTNTSEDKCEKDNMLGSNKTNTICPDNYQTAQLLALILELLT 520

  Fly   504 FCVEHHSYHIKNFLLQKDLLKRILVLMKSTHTFLVLGALRLLRKIIALKDEFYNRHIVKCNLFAP 568
            ||||||:|||||:::.||||:|:||||.|.||||.|.|||.:|:||.||||||||:|.|.|||.|
  Rat   521 FCVEHHTYHIKNYIMNKDLLRRVLVLMNSKHTFLALCALRFMRRIIGLKDEFYNRYITKGNLFEP 585

  Fly   569 VVDAFIRNNGRYNLLESAILELFEFIKLEDIRTLCVYFVENFSKIFDEIEYVQTFKYLKNRYDQY 633
            |::|.:.|..|||||.||::||||||::|||::|..:.||||.|..:.||||||||.||.:|:|.
  Rat   586 VINALLDNGTRYNLLNSAVIELFEFIRVEDIKSLTAHIVENFYKALESIEYVQTFKGLKTKYEQE 650

  Fly   634 QDRLKDRDKMENRTDGGLPIIRSGGRFRRDQRQMEEEEEMWFNEEDD-------------FTEE- 684
            :||       :|:....:|.|....|||||.:.:||:|||||||:||             .||:
  Rat   651 KDR-------QNQKLNSVPSILRSNRFRRDAKALEEDEEMWFNEDDDEEGKSVVTPVEKTKTEDD 708

  Fly   685 -IDTYNNVMKSVSEKNGPQTQNQQKSSP------PHSTSPHSGLLGSLSTTASSTATSATSGAPV 742
             .|:|...|::...|.....:|..|.:.      ..|.|| |...|:.||.:.|.....|..:
  Rat   709 FPDSYEKFMETKKAKESEDKENLPKRTSSGGFKFTFSHSP-SAANGTNSTNSKSVVAQTTPAS-- 770

  Fly   743 ASGSSSPEAISADEQTQAAVHLAAAALQHHQQQQQQQQQNPFQQQTQPEI 792
            ::||||.....|...|  |...:...|..:...:::.::.....:.:|.:
  Rat   771 SNGSSSKTTNLATSVT--ATKGSLVGLVDYPDDEEEDEEEESSPRKRPRL 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flfl	NP_731849.2	PH-like	8..>66	CDD:302622	49/57 (86%)
flfl	NP_731849.2	SMK-1	169..361	CDD:282636	122/191 (64%)
Ppp4r3b	NP_001101837.1	PH-like	7..>65	CDD:418428	49/57 (86%)
Ppp4r3b	NP_001101837.1	SMK-1	168..359	CDD:398462	122/191 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	353	1.000	Domainoid score	I969
eggNOG	1	0.900	-	-		E1_KOG2175
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68886
Inparanoid	1	1.050	877	1.000	Inparanoid score	I388
OMA	1	1.010	-	-		QHG54949
OrthoDB	1	1.010	-	-		D261288at33208
OrthoFinder	1	1.000	-	-		FOG0001376
OrthoInspector	1	1.000	-	-		otm45884
orthoMCL	1	0.900	-	-		OOG6_101106
Panther	1	1.100	-	-	LDO	PTHR23318
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X869
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840