DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment flfl and ppp4r3b

DIOPT Version :9

Sequence 1:	NP_731849.2	Gene:	flfl / 41675	FlyBaseID:	FBgn0024555	Length:	980	Species:	Drosophila melanogaster
Sequence 2:	NP_956295.2	Gene:	ppp4r3b / 336198	ZFINID:	ZDB-GENE-030131-8142	Length:	778	Species:	Danio rerio

Alignment Length:	802	Identity:	419/802 - (52%)
Similarity:	555/802 - (69%)	Gaps:	73/802 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TDTRRRVKLYALNAERQWDDRGTGHVSSTYVERLKGISLLVRAESDGSLLLESKIQPDTAYQKQQ 67
            :|||||||:|.||.||||:|||||||..:    .:..:|.|.|||||||||||||:|.|||||||
Zfish     2 SDTRRRVKVYTLNEERQWEDRGTGHVCCS----AEDTALSVTAESDGSLLLESKIKPSTAYQKQQ 62

  Fly    68 DTLIVWSEGDNFDLALSFQEKAGCDEIWEKICQVQGKDPSVEITQDIVEESEDERFEDMSDTAPP 132
            ||||||||.:|:|||||||||||||||||||||||||||||||||:.|:|||:||.||.......
Zfish    63 DTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVEITQEPVDESEEERCEDSGAECDA 127

  Fly   133 IELPPCELSRLEDISETIQSCLSTPLRKEKLSMALESESYIKKLLNLFHVCEDLDNTEGLHHLFE 197
            ::||.|...||::::|.:.|.|.:|:|:|||::||.|..|:::||.||..||:.:|...|..||:
Zfish   128 LDLPECVPERLQELAELVSSVLPSPVRREKLALALVSGGYLRQLLLLFRRCEEQENRPRLQQLFQ 192

  Fly   198 IFKNIFLLNKNALFEIMFADDTIFDVVGCLEYDPSVSQPKKHRQYLKQLAKFREAVPIKNLDLLA 262
            |.:.:..|||.||||::|:||.|.||||||||||::.|||:||.:|.:.|:|||.:||::.:|..
Zfish   193 ILRGLLFLNKAALFEVLFSDDCIMDVVGCLEYDPALLQPKRHRDFLTKTARFREVIPIQDSELRQ 257

  Fly   263 KIHQTFRVQYIQDIILPTPSVFVEDNMLNTLSSFIFFNKVEIVTMIQDDERYLLDVFAVLTDPTT 327
            |||||:|||||||||||||||| |:|.|:||||||||||||||:|:|:||::|.:|||.|||.:|
Zfish   258 KIHQTYRVQYIQDIILPTPSVF-EENFLSTLSSFIFFNKVEIVSMLQEDEKFLTEVFAQLTDEST 321

  Fly   328 GDAKRRDTVLFLKEFCNYAQNLQPQGKDSFYKTLTCLGILQALELTLVMNDKKTKSASIDILTAI 392
            .|:|||:.|.|.||||.::|.||||.:|:|:|||..||||.|||:.:.|:|.:.|:|:.||.:.:
Zfish   322 EDSKRRELVNFFKEFCAFSQTLQPQNRDAFFKTLANLGILPALEIVMGMDDVQVKAAATDIFSYL 386

  Fly   393 VEFSPLVVRNYTLNQANRPEVERMLLNIAIEQMLNDSEPELGIAVQLMGIVKILLEPENML---- 453
            |||||.:||.:.:.:..:.:.:.:|:|:.|:||:.||:||||.||||||:::.|::|||||
Zfish   387 VEFSPSMVREFVMQEPQQADDDVLLINVVIKQMICDSDPELGGAVQLMGLLRTLIDPENMLAPSN 451

  Fly   454 -TEKGDFLNFFYKYSVQTLVAPVILNTI--------GDRPQN----EDYQTAQLLGIVLDILSFC 505
             |||.:||:|||||.:..|.||::.||.        |....|    :::||||||.::|::|:||
Zfish   452 KTEKSEFLSFFYKYCMHVLTAPLLANTAEEDQDLDEGSAKVNPVCPDNFQTAQLLALILELLTFC 516

  Fly   506 VEHHSYHIKNFLLQKDLLKRILVLMKSTHTFLVLGALRLLRKIIALKDEFYNRHIVKCNLFAPVV 570
            ||||:|||||:::.:|||:|:|.||.|.||||.|.|||.:|:||.||||:|||:|:|.|||.||:
Zfish   517 VEHHTYHIKNYIMTRDLLRRVLTLMNSKHTFLALCALRFMRRIIGLKDEYYNRYIMKGNLFEPVI 581

  Fly   571 DAFIRNNGRYNLLESAILELFEFIKLEDIRTLCVYFVENFSKIFDEIEYVQTFKYLKNRYDQYQD 635
            :|.:.|..|||||.|||:|||:||::||||:|..:.||||......|:||||||.||.||:|.|:
Zfish   582 NALLDNGTRYNLLNSAIIELFDFIRVEDIRSLTAHIVENFQSALQSIQYVQTFKGLKGRYEQEQE 646

  Fly   636 RLKDRDKMENRTDGGLPIIRSGGRFRRDQRQMEEEEEMWFNEEDDFTEEIDT--------YNNVM 692
            |..                |...|||||.|...|:||:|..||:|..|..||        |...|
Zfish   647 RQS----------------RGLSRFRRDARSFPEDEELWKEEEEDEEEPADTETQHCKSDYGRFM 695

  Fly   693 KSVSEKNGPQTQNQQKSSPPHSTSPHSGLLGSLSTTASSTATSATSGAPVASGSSSPEAISA--- 754
            :|...|...:.:||.|.|..          ||...|.|.:|.||.| |...|.|||..:.:|
Zfish   696 ESEKAKENQEKENQAKRSSS----------GSFKFTFSHSAASANS-AKATSASSSGASTAARTA 749

  Fly   755 -------------DEQTQAAVH 763
                         |::.|.|.|
Zfish   750 LVDYPDDEDEDEDDDEDQQAPH 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flfl	NP_731849.2	PH-like	8..>66	CDD:302622	37/57 (65%)
flfl	NP_731849.2	SMK-1	169..361	CDD:282636	115/191 (60%)
ppp4r3b	NP_956295.2	SMK-1	178..355	CDD:282636	109/177 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H68886
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D261288at33208
OrthoFinder	1	1.000	-	-		FOG0001376
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101106
Panther	1	1.100	-	-	LDO	PTHR23318
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X869
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.920