DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment flfl and RGD1563554

DIOPT Version :9

Sequence 1:	NP_731849.2	Gene:	flfl / 41675	FlyBaseID:	FBgn0024555	Length:	980	Species:	Drosophila melanogaster
Sequence 2:	XP_038956417.1	Gene:	RGD1563554 / 317272	RGDID:	1563554	Length:	840	Species:	Rattus norvegicus

Alignment Length:	846	Identity:	334/846 - (39%)
Similarity:	506/846 - (59%)	Gaps:	83/846 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DTRRRVKLYALNAERQWDDRGTGHVSSTYVERLKGISLLVRAESDGSLLLESKIQPDTAYQKQQD 68
            |...|||:|.:..::||.|.|.|.:||.|::||:|:.|||.:|||||.:||.||||:..|||.|.
  Rat     3 DKLYRVKVYVMMEDKQWKDIGAGQISSKYIDRLQGVCLLVHSESDGSPILECKIQPNVPYQKHQG 67

  Fly    69 TLIVWSEGDNFDLALSFQEKAGCDEIWEKICQVQGKDPSVEITQDIVEESEDERFEDMSDTAPPI 133
            .:|:|||..|...|:.|||...|.|.||.|||||||||:|||||.:.::.|.  |:||..:...:
  Rat    68 KVIIWSEAKNHGTAIHFQEPNDCQETWEVICQVQGKDPNVEITQLLTDDLES--FKDMLLSWNKV 130

  Fly   134 ELPPCELSRLEDISETIQSCLSTPLRKEKLSMALESESYIKKLLNLFHVCEDLDNTEGLHHLFEI 198
            |:..|||..||:|::.:......|..|:.|::.||.|.||||||.||..||...|.:|||:|..|
  Rat   131 EMSSCELHTLENIADLLSFVNEAPSHKKILTLVLEKEGYIKKLLQLFKTCEKHQNIDGLHYLNNI 195

  Fly   199 FKNIFLLNKNALFEIMFADDTIFDVVGCLEYDPSVSQPKKHRQYLKQLAKFREAVPIKNLDLLAK 263
            .:.|..|:...||.|||:|:.|.||||||||.|.:.:||:|||:|.|..||:..:.|.:..|..|
  Rat   196 IRGILFLDNIHLFNIMFSDEFIMDVVGCLEYGPGLDEPKQHRQFLTQNVKFKNVMQITHSQLRKK 260

  Fly   264 IHQTFRVQYIQDIILPTPSVFVEDNMLNTLSSFIFFNKVEIVTMIQDDERYLLDVFAVLTDPTTG 328
            |.||:|:|||.||:|||||:| |.|:|:.||:.|||||:||:||:|:||.:||:|.|.|.|.|..
  Rat   261 IQQTYRMQYIYDIVLPTPSIF-EVNLLHDLSTMIFFNKIEIITMLQEDEHFLLEVLAQLKDNTVS 324

  Fly   329 DAKRRDTVLFLKEFCNYAQNLQPQGKDSFYKTLTCLGILQALELTLVMNDKKTKSASIDILTAIV 393
            :.:|.:.:||.||||.:|:.|..|.|::..|||..|||:.||::.:.|:|.:.:.|::::...:|
  Rat   325 NERRHELLLFFKEFCAFAKTLHFQKKNTLLKTLIKLGIISALKVVVHMHDYQIQVAALELFAHLV 389

  Fly   394 EFSPLVVRNYTLNQANRPE-VERMLLNIAIEQMLNDSEPELGIAVQLMGIVKILLEPENM-LTEK 456
            |:||.::|.|.:.:|...| .:.:|:||.|:||..||:||...::.|..::..:|:|||| :|.|
  Rat   390 EYSPRLIRAYAMKEAQYSEDNDGLLINIMIKQMTCDSDPEFSRSIILTTVLHAILDPENMRVTTK 454

  Fly   457 G----DFLNFFYKYSVQTLVAPVILNTIGDRPQN-------EDYQTAQLLGIVLDILSFCVEHHS 510
            |    .|||:||::.:..|:.|::..|:.:...:       ::||.|||||.:|:||:|||::||
  Rat   455 GHERRKFLNYFYRHCMNKLIEPILSITVENNSDDNRVNICPDNYQNAQLLGAILEILTFCVQYHS 519

  Fly   511 YHIKNFLLQKDLLKRILVLMKSTHTFLVLGALRLLRKIIALKDEFYNRHIVKCNLFAPVVDAFIR 575
            .::||:::.|:||.|||:||.|.||||:|.|:|.:||:|.|||:.||.:||:.|||.|||:||:.
  Rat   520 KYVKNYIISKNLLSRILILMSSKHTFLILCAVRFMRKMIGLKDKMYNLYIVEKNLFEPVVNAFMH 584

  Fly   576 NNGRYNLLESAILELFEFIKLEDIRTLCVYFVENFSKIFDEIEYVQTFKYLKNRYDQYQDRLKDR 640
            |..|||:|.|||:||||||:.|:|::|....||.|...|:.|:||||||.||.:|::.:.:.::|
  Rat   585 NGHRYNMLNSAIIELFEFIRQENIKSLIANIVEKFFMFFESIQYVQTFKGLKTKYEEEKKKKRER 649

  Fly   641 ------------------------------------DKMENRTDGGLPIIRSGGRFRRDQRQME- 668
                                                ||.|.|..||......|||....:...|
  Rat   650 QLRKSLHNIIYQRIYCRHIKAMEVKVKADIFCRQITDKEEEREKGGGGGEGGGGRGGEGEGGREG 714

  Fly   669 --EEEEMWFNEEDDFTE---------EIDTYNNVMKSVSEKNGPQTQN-----QQKSSPPHSTSP 717
              .|.|.....:....|         :|.::.::...::|.|  :.:|     ::|||   :||.
  Rat   715 GGREGEGGGGGKGGRGEGGAVLSMGSDIPSHYDMFVKINEMN--ERENVIECRKRKSS---ATSE 774

  Fly   718 HSGLLGSLSTTASSTATSATSGAPVASGSSSPEAISADEQTQAAVHLAAAALQHHQQQQQQQQQN 782
            :|...|..|....|| ...:|..|:...:...:....|.        :....::.:::::::::.
  Rat   775 YSTSCGDTSDNGIST-VYCSSLVPLVDYAYDTDGEDDDG--------SYGNNENEEEEEEEEEEE 830

  Fly   783 P 783
            |
  Rat   831 P 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flfl	NP_731849.2	PH-like	8..>66	CDD:302622	31/57 (54%)
flfl	NP_731849.2	SMK-1	169..361	CDD:282636	98/191 (51%)
RGD1563554	XP_038956417.1	PH-like	2..>71	CDD:418428	34/67 (51%)
RGD1563554	XP_038956417.1	SMK-1	166..357	CDD:398462	98/191 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D261288at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010