DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment flfl and RGD1563978

DIOPT Version :9

Sequence 1:	NP_731849.2	Gene:	flfl / 41675	FlyBaseID:	FBgn0024555	Length:	980	Species:	Drosophila melanogaster
Sequence 2:	XP_006257065.1	Gene:	RGD1563978 / 302447	RGDID:	1563978	Length:	788	Species:	Rattus norvegicus

Alignment Length:	797	Identity:	338/797 - (42%)
Similarity:	481/797 - (60%)	Gaps:	74/797 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DTRRRVKLYALNAERQWDDRGTGHVSSTYVERLKGISLLVRAESDGSLLLESKIQPDTAYQKQQD 68
            |....||::.|..:.||...|||.:||.|:|||:|:.|||.:|||||.::|.||.|:..|.||:.
  Rat     3 DKLHSVKVFVLVEDEQWKIIGTGQISSKYIERLQGVCLLVHSESDGSQIMECKIYPNVPYHKQRG 67

  Fly    69 TLIVWSEGDNFDLALSFQEKAGCDEIWEKICQVQGKDPSVEITQDIVEESEDERFEDMSDTAPPI 133
            .:|||||..|..:|:.|||.:||.||||.|||||||||||||||::.::.  |.|.|:.......
  Rat    68 EIIVWSEAKNHGMAIYFQEPSGCQEIWEDICQVQGKDPSVEITQEVTDDL--ETFADLLPIGNLF 130

  Fly   134 ELPPCELSRLEDISETIQSCLSTPLRKEKLSMALESESYIKKLLNLFHVCEDLDNTEGLHHLFEI 198
            |:|.|||:.||.|::.......||..:|:::|.||..|||||||.||:.||.|.|.|.||.|..|
  Rat   131 EMPNCELNTLEHIADLFTFVDKTPNHRERMAMVLEKGSYIKKLLQLFNTCEKLKNMEALHFLNNI 195

  Fly   199 FKNIFLLNKNALFEIMFADDTIFDVVGCLEYDPSVSQPKKHRQYLKQLAKFREAVPIKNLDLLAK 263
            .|.|..|:...|..|||:|:...||||||||||::.|||::|::|.|.|||||.:||.|..|..|
  Rat   196 IKGILFLDDTRLLNIMFSDEFFMDVVGCLEYDPALDQPKQYREFLLQNAKFREIMPITNSQLRQK 260

  Fly   264 IHQTFRVQYIQDIILPTPSVFVEDNMLNTLSSFIFFNKVEIVTMIQDDERYLLDVFAVLTDPTTG 328
            |.:|:|:||:.||:||.||:| :.|:|:.|::.|.|||.||:||:||||.:||:..:.|.|.|.|
  Rat   261 IQETYRMQYVYDIVLPAPSIF-DSNLLSDLNAMIIFNKSEIITMLQDDENFLLEALSQLKDNTVG 324

  Fly   329 DAKRRDTVLFLKEFCNYAQNLQPQGKDSFYKTLTCLGILQALELTLVMNDKKTKSASIDILTAIV 393
            ..:..:.:||.||||.:|:.|:.|.||...|||..|||:.||::.:.|:|.:.:.|::||...:|
  Rat   325 YERWYELLLFFKEFCIFAKALENQEKDELLKTLIKLGIMSALKVLVHMHDYQIQKAALDIFPYLV 389

  Fly   394 EFSPLVVRNYTLNQANRPE-VERMLLNIAIEQMLNDSEPELGIAVQLMGIVKILLEPENMLT--- 454
            |::|.:||.|.|.:|...| .:.:|:|:.|:||:.|.:||....:.|..:::.||:||||..
  Rat   390 EYNPCLVREYLLEEAQDSEDNDELLINVMIKQMIYDPDPEFSKDIILPAVLRALLDPENMHVTAN 454

  Fly   455 --EKGDFLNFFYKYSVQTLVAPVILNTI-GDRPQN-----EDYQTAQLLGIVLDILSFCVEHHSY 511
              ||..||||||...:..|:||::..|: .|...|     .:||.|||||::|:||:|||::||.
  Rat   455 GCEKAKFLNFFYARCMGNLIAPILSTTVENDTDDNMVNICPNYQNAQLLGVILEILTFCVQYHST 519

  Fly   512 HIKNFLLQKDLLKRILVLMKSTHTFLVLGALRLLRKIIALKDEFYNRHIVKCNLFAPVVDAFIRN 576
            ::||::|..:||.|||:||.|.||||:|.|:|.:||||:||||.||.:|:|.|||.|:|:||:.|
  Rat   520 YMKNYILNNNLLSRILMLMSSKHTFLILCAVRFMRKIISLKDEIYNLYIIKKNLFEPIVNAFMHN 584

  Fly   577 NGRYNLLESAILELFEFIKLEDIRTLCVYFVENFSKIFDEIEYVQTFKYLKNRYDQYQDRLKDRD 641
            ..|||:|.|||:||||||:.|:|::|....||||...|:.||||||||.||.:|::
  Rat   585 GTRYNMLNSAIIELFEFIRQENIKSLIANIVENFFIAFESIEYVQTFKGLKTKYEE--------- 640

  Fly   642 KMENRTDGGLPIIRSGGRFRRDQ--------------------------RQMEEEEEMWFNEEDD 680
              |.:.:.|:         ||:.                          |::.|||........:
  Rat   641 --EKKRESGI---------RRNLYNVIYQKIYCRHIKVMELKVKADICCREITEEEGAILPMGKE 694

  Fly   681 FTEEIDTYNNVMKSVSEKNGPQTQNQQKSSPPHSTSPHSGLLGSLSTTASSTATSATSGAPV--- 742
            |...   |:.:|| :.|.|  :.:|..:....:.||..|...|..|:...| ....:|..|:
  Rat   695 FPSH---YDIIMK-IKETN--ENENVIEHPKSNETSKCSSSCGDASSNKMS-MVHCSSLVPLVDY 752

  Fly   743 ---ASGSSSPEAISADE 756
               ..|.|..:....||
  Rat   753 PYDTDGESDDDPYGNDE 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flfl	NP_731849.2	PH-like	8..>66	CDD:302622	28/57 (49%)
flfl	NP_731849.2	SMK-1	169..361	CDD:282636	97/191 (51%)
RGD1563978	XP_006257065.1	PH-like	2..>62	CDD:418428	28/58 (48%)
RGD1563978	XP_006257065.1	SMK-1	166..357	CDD:398462	97/191 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D261288at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010