DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment flfl and 4930415L06Rik

DIOPT Version :9

Sequence 1:	NP_731849.2	Gene:	flfl / 41675	FlyBaseID:	FBgn0024555	Length:	980	Species:	Drosophila melanogaster
Sequence 2:	NP_001029052.2	Gene:	4930415L06Rik / 245511	MGIID:	3588286	Length:	813	Species:	Mus musculus

Alignment Length:	761	Identity:	337/761 - (44%)
Similarity:	474/761 - (62%)	Gaps:	52/761 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VKLYALNAERQWDDRGTGHVSSTYVERLKGISLLVRAESDGSLLLESKIQPDTAYQKQQDTLIVW 73
            ||:|.:..::||.:.|||.:||.|.|:|:|:.|||.:.||||.::|.||.|:..|||||..:|:|
Mouse    20 VKVYVMMEDKQWKNVGTGQISSKYSEQLQGVCLLVHSLSDGSPIMECKIHPNVPYQKQQGKIIIW 84

  Fly    74 SEGDNFDLALSFQEKAGCDEIWEKICQVQGKDPSVEITQDIVEESEDERFEDMSDTAPPIELPPC 138
            ||..|..:|:.|||...|.||||.|||:|||||.|||||::.::.  |.||.|......:|:..|
Mouse    85 SEAKNHGMAIHFQEPNDCQEIWEDICQIQGKDPHVEITQELTDDL--ETFEHMPLIWNWVEMSNC 147

  Fly   139 ELSRLEDISETIQSCLSTPLRKEKLSMALESESYIKKLLNLFHVCEDLDNTEGLHHLFEIFKNIF 203
            |:..|::|:|........|.:||:|::.||:|.||||||.|||.||.|.|.|||::|..|.|.|.
Mouse   148 EIHTLKNIAELFPFVFEMPSQKERLALFLENEGYIKKLLQLFHTCEKLKNMEGLYYLHNIIKGIL 212

  Fly   204 LLNKNALFEIMFADDTIFDVVGCLEYDPSVSQPKKHRQYLKQLAKFREAVPIKNLDLLAKIHQTF 268
            .||...||.|||:|:...|:||||||||::.|||::|::|.|.:||:|.:||.:..|..||.||:
Mouse   213 FLNNTRLFNIMFSDEFFMDIVGCLEYDPALDQPKQYREFLTQNSKFKEVIPIIHSQLRQKIQQTY 277

  Fly   269 RVQYIQDIILPTPSVFVEDNMLNTLSSFIFFNKVEIVTMIQDDERYLLDVFAVLTDPTTGDAKRR 333
            |:||:.||:|||||:| :.|:|:.:::.|||||:.|:||||:||.:||:||:.|.|.:.||.:|.
Mouse   278 RMQYVHDIMLPTPSIF-QTNLLSDITTMIFFNKINIITMIQEDENFLLEVFSQLKDNSIGDERRI 341

  Fly   334 DTVLFLKEFCNYAQNLQPQGKDSFYKTLTCLGILQALELTLVMNDKKTKSASIDILTAIVEFSPL 398
            :.:|||||||.:|:.||.|.|:...|||..|||:..|::.:.|||.:.:..::||...:||:||.
Mouse   342 ELLLFLKEFCEFAKTLQSQKKNELLKTLIKLGIMSVLKVVVHMNDYQIQVGALDIFAYLVEYSPC 406

  Fly   399 VVRNYTLNQANRPE-VERMLLNIAIEQMLNDSEPELGIAVQLMGIVKILLEPENMLT-----EKG 457
            :||.|.:.:|...| .:.:|:||.|:||:.|.:||....:.:..::..||.||||.|     |:.
Mouse   407 LVRAYAMEEAQDSEDNDDLLINIMIKQMICDFDPEFSQGIIMTAVLHELLNPENMRTTAKGCERK 471

  Fly   458 DFLNFFYKYSVQTLVAPVI-LNTIGDRPQN------EDYQTAQLLGIVLDILSFCVEHHSYHIKN 515
            .|||||||..::.|:||:: :....|...|      ::||.|||||.||:||:|||::||.:||:
Mouse   472 VFLNFFYKRYMRKLIAPILSIRVKYDSNDNRVYICPDNYQNAQLLGAVLEILTFCVQYHSMYIKH 536

  Fly   516 FLLQKDLLKRILVLMKSTHTFLVLGALRLLRKIIALKDEFYNRHIVKCNLFAPVVDAFIRNNGRY 580
            ::...:||:.|||||.|.||||:|.|:|.:||||.|||:.||.:|:|.|||.|||:||:.|..||
Mouse   537 YIFSNNLLRSILVLMSSKHTFLILCAVRFMRKIIGLKDKMYNHYIIKKNLFEPVVNAFMHNGHRY 601

  Fly   581 NLLESAILELFEFIKLEDIRTLCVYFVENFSKIFDEIEYVQTFKYLKNRYDQYQDRLKDRDKMEN 645
            |:|.|||:||||||:.|:|.:|.|..||||.:.|..||||||||.||.:|::.:.|...|.|
Mouse   602 NMLNSAIIELFEFIRKENITSLIVNIVENFFRAFKSIEYVQTFKGLKTKYEEEKKRKSQRRK--- 663

  Fly   646 RTDGGLPIIRSGGRFRRDQRQM--------------EEEEEMWFNEE-------DDFTEEIDTYN 689
                .|..|.....:.|....|              ||||.....||       .|||...|.:.
Mouse   664 ----NLHSIMHPKMYYRHIEDMEVKVKADICCRGIIEEEERQGGGEEGAILPMGSDFTNNYDIFM 724

  Fly   690 NVMKSVSEKNGPQTQNQQKSSPPHSTSPHSGLLGSLSTTASSTATS 735
            . .|..:|........:.|||......|..|       .||:|..|
Mouse   725 K-NKDTNESESAIEGQKIKSSEASECCPSHG-------DASATRMS 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flfl	NP_731849.2	PH-like	8..>66	CDD:302622	27/56 (48%)
flfl	NP_731849.2	SMK-1	169..361	CDD:282636	101/191 (53%)
4930415L06Rik	NP_001029052.2	PH-like	17..>83	CDD:302622	30/62 (48%)
		SMK-1	178..369	CDD:282636	101/191 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	730..813		10/40 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2175
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54949
OrthoDB	1	1.010	-	-		D261288at33208
OrthoFinder	1	1.000	-	-		FOG0001376
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101106
Panther	1	1.100	-	-	O	PTHR23318
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X869
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.790