DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment flfl and 4932429P05Rik

DIOPT Version :9

Sequence 1:	NP_731849.2	Gene:	flfl / 41675	FlyBaseID:	FBgn0024555	Length:	980	Species:	Drosophila melanogaster
Sequence 2:	NP_001078980.1	Gene:	4932429P05Rik / 245509	MGIID:	3588287	Length:	785	Species:	Mus musculus

Alignment Length:	759	Identity:	325/759 - (42%)
Similarity:	475/759 - (62%)	Gaps:	48/759 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DTRRRVKLYALNAERQWDDRGTGHVSSTYVERLKGISLLVRAESDGSLLLESKIQPDTAYQKQQD 68
            |....||:|.:..:.||...|.|.:||.|:|||:|:.|:|::||||||::|.||.|:..|.||:.
Mouse     3 DKLHSVKIYVMVEDEQWKGIGAGQISSKYIERLQGVCLIVQSESDGSLIMECKIHPNVPYHKQRG 67

  Fly    69 TLIVWSEGDNFDLALSFQEKAGCDEIWEKICQVQGKDPSVEITQDIVEESEDERFEDMSDTAPPI 133
            .:|:|||..|..:|:.|||..||.||||.|||||||||:||||:::.:..  :.||::......:
Mouse    68 EIIIWSETKNHGMAIHFQEPNGCQEIWEDICQVQGKDPNVEITEELTDNL--KTFEELLPIWNLV 130

  Fly   134 ELPPCELSRLEDISETIQSCLSTPLRKEKLSMALESESYIKKLLNLFHVCEDLDNTEGLHHLFEI 198
            |:..|||..||:|::.......||..||:|.:.||...||||||..|:.||.|.|.|.|::|..|
Mouse   131 EMQNCELHTLENIADLFTFVHETPSHKERLVLVLEKGVYIKKLLQHFNTCEKLKNMESLYYLNNI 195

  Fly   199 FKNIFLLNKNALFEIMFADDTIFDVVGCLEYDPSVSQPKKHRQYLKQLAKFREAVPIKNLDLLAK 263
            .|.|..|:...||.|||:|:...|:||||||||::..||::|::|.|.|||:|.:||.:..|...
Mouse   196 IKGILFLDNTHLFNIMFSDEFFMDMVGCLEYDPALDHPKQYREFLTQNAKFKEILPITHFQLRQT 260

  Fly   264 IHQTFRVQYIQDIILPTPSVFVEDNMLNTLSSFIFFNKVEIVTMIQDDERYLLDVFAVLTDPTTG 328
            |.||:|:||:.||:||.||: .|.|:|..|::.|.:||:||:||:||||.:||:|.|.|.|.|.|
Mouse   261 IQQTYRMQYVHDIVLPIPSI-CESNLLYGLNTMIIYNKIEIITMLQDDENFLLEVLARLKDNTVG 324

  Fly   329 DAKRRDTVLFLKEFCNYAQNLQPQGKDSFYKTLTCLGILQALELTLVMNDKKTKSASIDILTAIV 393
            :.:|.:.:||.||||.:|:.|:...|....|||..||::.||:..:.|:|.:.:.|::||...:|
Mouse   325 NDRRHELLLFFKEFCTFAKTLENLEKHELLKTLINLGVMSALKAVVHMHDYQIQIAALDIFPYLV 389

  Fly   394 EFSPLVVRNYTLNQANRPEVERMLLNIAIEQMLNDSEPELGIAVQLMGIVKILLEPENM-LTEKG 457
            |::|.:||.|.|::|:..:.:.:.|||.|:||:.:|:|.....:.|..|:..||:|||| :|..|
Mouse   390 EYNPCLVREYLLDEAHDTDDDDLFLNIMIKQMICNSDPRFSQGIILPAILCALLDPENMHVTANG 454

  Fly   458 ----DFLNFFYKYSVQTLVAPVILNTIGDRPQN-------EDYQTAQLLGIVLDILSFCVEHHSY 511
                :||||||...:..|:||::..|:.....|       ::||.|||||:|::||:|||::||.
Mouse   455 CEEKEFLNFFYTRCINNLIAPILSATVEKENANNRANICPDNYQNAQLLGVVIEILTFCVQYHST 519

  Fly   512 HIKNFLLQKDLLKRILVLMKSTHTFLVLGALRLLRKIIALKDEFYNRHIVKCNLFAPVVDAFIRN 576
            :||:::|..:||.||||||.|.||||:|.|:|.:||:|.||||.||.:|:|.|||.|||:||:.|
Mouse   520 YIKSYILDNNLLSRILVLMTSKHTFLILCAVRFMRKLIGLKDEIYNLYIIKENLFEPVVNAFMHN 584

  Fly   577 NGRYNLLESAILELFEFIKLEDIRTLCVYFVENFSKIFDEIEYVQTFKYLKNRYDQYQDRLKDRD 641
            ..|||:|.|||:||||||:.|:|::|....||||...|:.||||||||.||.:|::.::..:.|.
Mouse   585 GHRYNMLNSAIIELFEFIRQENIKSLIANIVENFFISFESIEYVQTFKGLKIKYEEEKNECQVRR 649

  Fly   642 KMEN----------RTDGGLPIIRSGGRFRRD--QRQMEEEEEMWFNEEDDFTEEIDTYNNVMKS 694
            .:.|          ..|.||.:       :.|  .|::.|.:|.......||...   |..:||
Mouse   650 NLLNVVCQKIYCICTNDMGLKV-------KSDICHRRITETKEAILPNRRDFPSH---YGIIMK- 703

  Fly   695 VSEKNGPQT--QNQQ-KSSPPHSTSPHSGLLGSLSTTASSTATS 735
            :.|.|..::  :.|: |||......|..|       .||:|..|
Mouse   704 IEETNESESAIEGQKIKSSEAFERCPSHG-------DASATRMS 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flfl	NP_731849.2	PH-like	8..>66	CDD:302622	27/57 (47%)
flfl	NP_731849.2	SMK-1	169..361	CDD:282636	91/191 (48%)
4932429P05Rik	NP_001078980.1	PH-like	2..>62	CDD:302622	27/58 (47%)
4932429P05Rik	NP_001078980.1	SMK-1	169..357	CDD:282636	91/188 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2175
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54949
OrthoDB	1	1.010	-	-		D261288at33208
OrthoFinder	1	1.000	-	-		FOG0001376
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101106
Panther	1	1.100	-	-	O	PTHR23318
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X869
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.790