Protein Alignment flfl and smk-1

DIOPT Version :10

• Sequence 1: NP_731849.2
• Gene: flfl / 41675
• FlyBaseID: FBgn0024555
• Length: 980
• Species: Drosophila melanogaster
• Sequence 2: NP_001023909.2
• Gene: smk-1 / 179243
• WormBaseID: WBGene00018285
• Length: 1085
• Species: Caenorhabditis elegans
• Alignment Length: 989
• Identity: 332/989 - (33%)
• Similarity: 533/989 - (53%)
• Gaps: 158/989 - (15%)

  Fly     4 DTRRRVKLYALNAERQWDDRGTGHVSSTYVERLKG-------ISLLVRAESDGSLLLESKIQPDT 61
            |...|||||.|..:|.|:|||||||.:..:....|       ..:|||.|.....:|||:||.||
 Worm   171 DATNRVKLYVLCDQRIWEDRGTGHVVTHQLSAEDGAPSNAGNTMVLVRLEGQNKNMLESRIQMDT 235

  Fly    62 AYQKQQDTLIVWSEGDNFDLALSFQEKAGCDEIWEKICQVQGKDP-SVEITQDIVEESEDERFED 125
            .|||||:|||||||.|..|||||||||:||:|:|:|||:|||:|| ..:.|.|   :.:|....:
 Worm   236 VYQKQQETLIVWSETDVMDLALSFQEKSGCEELWQKICEVQGRDPGDPDATFD---DGDDSDVGE 297

  Fly   126 MSDTAPPIELPPCELSRLEDISETIQSCLSTPLRKEKLSMALESESYIKKLLNLFHVCEDLDNTE 190
            |..:|..::|||.|:.||.::...:...|:|...:||:::|:|:::.:.||..:|.:|||:::||
 Worm   298 MPSSASRLQLPPIEIGRLGELDALLHMHLTTNSAREKMTLAIENDNVVTKLCEVFRMCEDIEHTE 362

  Fly   191 GLHHLFEIFKNIFLLNKNALFEIMFADDTIFDVVGCLEYDPSVSQPKKHRQYLKQLAKFREAVPI 255
            ||...:.|.||:|:||:|.:.|::..|:.|.||:|..|:||:...|:|||.::.:.|||||.:.|
 Worm   363 GLRTFYSIVKNLFMLNRNTVIEMLLDDNNIKDVIGMFEFDPAYKHPRKHRDFVYKKAKFREVLNI 427

  Fly   256 KNLDLLAKIHQTFRVQYIQDIILPTPSVFVEDNMLNTLSSFIFFNKVEIVTMIQDDERYLLDVFA 320
            ...:|..|||:.:|.|||||..||:..:| |:|:|:||||.:||.:|:|||::|.|::.:.::|.
 Worm   428 SCDELRDKIHRLYRAQYIQDACLPSLGLF-EENLLSTLSSHVFFCRVDIVTLLQKDKKAMSELFG 491

  Fly   321 VLTDPTTGDAKRRDTVLFLKEFCNYAQNLQPQG----KDSFYK----TLTCLGILQALELTLVMN 377
            .|....|...:|||..|||||..:.:.::...|    |::|:|    .:....||.:||......
 Worm   492 QLISEETDVIRRRDLALFLKEMISLSTSIPSNGPAATKETFFKLQLQNMFNSEILDSLEPCFKSP 556

  Fly   378 DKKTKSASIDILTAIVEFSPLVVRNYTLNQA-NRPEVERMLLNIAIEQMLNDSEPELGIAVQLMG 441
            |.:|::..:|:|..:|:.:..::|::.|.|: .:.:.|.:|||:.|..:|.|.:..|....:::.
 Worm   557 DHETRAVMVDVLRTMVDANAQMIRDFLLKQSKTKDKNEDVLLNMMIRHLLTDIDVHLTSGSEIVL 621

  Fly   442 IVKILLEPENMLT---EKGDFLNFFYKYSVQTLVAPVILNTIGDRPQNEDYQTAQLLGIVLDILS 503
            |:|.||:||||.|   |:.|||..||....::|:.|::.|..|...:.:||..|....::|.:|:
 Worm   622 IMKTLLDPENMTTVKSERSDFLQLFYNRCYESLLKPILENVSGGNIKKDDYMIANRQSVILRLLT 686

  Fly   504 FCVEHHSYHIKNFLLQKDLLKRILVLMKSTHTFLVLGALRLLRKIIALKDEFYNRHIVKCNLFAP 568
            |||||||:.::...:..||:.::|||:||.|:||||.||:||::::.:||:.|.|:|||..:..|
 Worm   687 FCVEHHSFSMRQRCVSNDLMNKVLVLLKSKHSFLVLSALKLLQRVVTVKDDKYIRYIVKEKVLDP 751

  Fly   569 VVDAFIRNNGRYNLLESAILELFEFIKLEDIRTLCVYFVENFSKIFDEIEYVQTFKYLKNRYDQY 633
            |::.|.:|..|||::.|::|.||||::.||:|.|..|.|||..::.|.:.||:|||.:|.||||:
 Worm   752 VMECFRKNGNRYNIINSSVLHLFEFVRSEDVRPLIKYVVENHMEVVDSVNYVKTFKEIKIRYDQH 816

  Fly   634 QDRLKDRDKMENRT-DGGLPIIRSGGRFRRDQRQMEEEEEMWFNEEDDFTEEIDTYNNVMKSVSE 697
            :||   .:.|..|: |..|...||   ||:|:     .|:.||:|::|.  |:.|   :::|: |
 Worm   817 RDR---EETMSVRSEDNSLASPRS---FRKDR-----NEDQWFDEDEDL--EVGT---MLESI-E 864

  Fly   698 KNGPQTQNQQKSSPPHSTSPHSGLLGSLSTTASSTATSATSGAPVASGSSSPEAISADEQTQAAV 762
            |:                               |.|.|
 Worm   865 KD-------------------------------SVAVS--------------------------- 871

  Fly   763 HLAAAALQHHQQQQQQQQQNPFQQQTQPEIAELQQQLSSVEAPQSQELELSQSAAASASPTSSSS 827
                      .::::..|:....:...|.:.:.:......|||     .....:||..:.|....
 Worm   872 ----------PKKEEAGQRKTGMEPMFPSLLKRKNAFDDDEAP-----VFGGGSAAVINNTEKKI 921

  Fly   828 SLEAST--SSSSASSSSSSSSSSSPPGSSAAASLCDSATVAAVAASQFLSTIATAMAASVTAAAA 890
            .::.::  |.|...|.:||..:||.||.|..    |..|                        ::
 Worm   922 VIKVNSDRSPSRTPSPASSPRASSSPGPSRD----DEVT------------------------SS 958

  Fly   891 TNSSPSISPAPAVSS-PDIENAD--AQLPPSDDA---SSPASGEQDANSTEGTSSEADKTTAKKG 949
            .|:..| ||.|.|.| .|.:.:|  ...|||.||   ||..|.|::.:|.:|...::.:..
 Worm   959 QNNKES-SPTPTVKSLVDYDESDDSDDDPPSPDAVPSSSTGSPEKEGDSADGKKGDSPEYN---- 1018

  Fly   950 LVDYESDSGEDDYE 963
              |..|.|.|:.::
 Worm  1019 --DVSSTSNEEKFD 1030

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
flfl	NP_731849.2	PH-like	8..>66	CDD:473070	29/64 (45%)
		PP4R3	169..361	CDD:461435	79/199 (40%)
smk-1	NP_001023909.2	PP4R3	341..534	CDD:461435	78/193 (40%)