DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment flfl and PPP4R3C

DIOPT Version :9

Sequence 1:	NP_731849.2	Gene:	flfl / 41675	FlyBaseID:	FBgn0024555	Length:	980	Species:	Drosophila melanogaster
Sequence 2:	NP_997202.3	Gene:	PPP4R3C / 139420	HGNCID:	33146	Length:	832	Species:	Homo sapiens

Alignment Length:	842	Identity:	352/842 - (41%)
Similarity:	528/842 - (62%)	Gaps:	77/842 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RRRVKLYALNAERQWDDRGTGHVSSTYVERLKGISLLVRAESDGSLLLESKIQPDTAYQKQQDTL 70
            |..||:|.||.:.:|::.|||.|||||.|:.:|:|||||::||||::|.|:|.||..|.|.|:||
Human     5 RYSVKVYVLNEDEEWNNLGTGQVSSTYDEQFQGMSLLVRSDSDGSVILRSQIPPDRPYGKYQETL 69

  Fly    71 IVWSEGDNFDLALSFQEKAGCDEIWEKICQVQGKDPSVEITQDIVEESEDERFEDMSDTAPPIEL 135
            |||.|.:|..|.|.||:.|||.:||::|||.||||||::.|.:|.:|.|:: |.:||..:..:.|
Human    70 IVWYEAENQGLVLKFQDPAGCQDIWKEICQAQGKDPSIQTTVNISDEPEED-FNEMSVISNMVVL 133

  Fly   136 PPCELSRLEDISETIQSCLSTPLR-KEKLSMALESESYIKKLLNLFHVCEDLDNTEGLHHLFEIF 199
            |.|||:.|:.|::.:.|..|:|:. :|:|:..|::|:||.|||.|||.||:|:||||||||:||.
Human   134 PDCELNTLDQIADIVTSVFSSPVTDRERLAEILKNEAYIPKLLQLFHTCENLENTEGLHHLYEII 198

  Fly   200 KNIFLLNKNALFEIMFADDTIFDVVGCLEYDPSVSQPKKHRQYLKQLAKFREAVPIKNLDLLAKI 264
            |.|..||:..||||||:|:.|.||||||||||::.|||:||.:|...|||:|.:||.|.:|..||
Human   199 KGILFLNEACLFEIMFSDECIMDVVGCLEYDPALDQPKRHRDFLTNDAKFKEVIPITNSELRQKI 263

  Fly   265 HQTFRVQYIQDIILPTPSVFVEDNMLNTLSSFIFFNKVEIVTMIQDDERYLLDVFAVLTDPTTGD 329
            |||:|:|||.||:||.||:| |||.|:||::|||.||.|||:|:|.|.::|.:|||.|.|.||.|
Human   264 HQTYRLQYIYDILLPVPSIF-EDNFLSTLTTFIFSNKAEIVSMLQKDHKFLYEVFAQLKDETTHD 327

  Fly   330 AKRRDTVLFLKEFCNYAQNLQPQGKDSFYKTLTCLGILQALELTLVMNDKKTKSASIDILTAIVE 394
            .:|.:.:.|.||.|:::|.||||.||:.::||..||:|.||::.::.:|.:.:||:..|...:||
Human   328 DRRCELLFFFKELCSFSQALQPQSKDALFETLIQLGVLPALKIVMIRDDLQVRSAAAVICAYLVE 392

  Fly   395 FSPLVVRNYTLNQANRPEVERMLLNIAIEQMLNDSEPELGIAVQLMGIVKILLEPENMLT----- 454
            :||..:|.:.:::|:..:...:.:|:.|:||:.|::||||.||.||.::..||:|.||||
Human   393 YSPSRIREFIISEAHVCKDSDLFINVIIKQMICDTDPELGGAVHLMVVLHTLLDPRNMLTTPEKS 457

  Fly   455 EKGDFLNFFYKYSVQTLVAPVILNTIG-----------DRPQN--EDYQTAQLLGIVLDILSFCV 506
            |:.:||:||||:.:....||::..|..           |:.:|  .|.||||||.::|::|:||:
Human   458 ERSEFLHFFYKHCMHKFTAPLLAATSEHNCEEDDIAGYDKSKNCPNDNQTAQLLALILELLTFCI 522

  Fly   507 EHHSYHIKNFLLQKDLLKRILVLMKSTHTFLVLGALRLLRKIIALKDEFYNRHIVKCNLFAPVVD 571
            :||:::|::::|.||||::.|:||.|.||.|:|..||.:|::|.|.||.||.:|:|.|||.|||:
Human   523 QHHTFYIRSYILNKDLLRKALILMNSKHTHLILCVLRFMRRMICLNDEAYNNYIIKGNLFEPVVN 587

  Fly   572 AFIRNNGRYNLLESAILELFEFIKLEDIRTLCVYFVENFSKIFDEIEYVQTFKYLKNRYDQYQDR 636
            |.:.|..|||:|.||||||||:|::|:|:.|..:.||.|....:.||||||||.||.:|::.:||
Human   588 ALLDNGTRYNMLNSAILELFEYIRVENIKPLVSHIVEKFYNTLESIEYVQTFKGLKIKYEKERDR 652

  Fly   637 LKDRDK---------------------------MENRTDGGLPIIRSGGRFRRDQRQMEEEEEMW 674
            .....|                           ||:..:..:|.:.....|...:|..|.|..|.
Human   653 QSQIQKNLHSVLQNIVVFRGTIEEIGLEEEICFMEDAGEVVMPPLEDDDEFMETKRTQEGEAVMP 717

  Fly   675 FNEEDD-FTEEIDTYNNVMKSVSEKNGPQTQNQQKSSPPHSTSPHSGLLGSLSTTASST-ATSAT 737
            ..|:|| |||...|:..     .|...|..::..:.........|.|.:.|...|:|.. ..|::
Human   718 PLEDDDKFTETKRTHQE-----GEAVMPPLEDDDEFMETKRNQEHEGKVDSPKRTSSGDFKFSSS 777

  Fly   738 SGAPVASGSSSPEAISA--------DEQTQAAVHLAAAALQHHQQQQQQQQQNPFQQQTQPE 791
            ..|..|.|:.||...|.        ||:              .:::.:::::...:.:|.|:
Human   778 YSACAAIGTGSPSGSSVVRLVDHPDDEE--------------EKEEDEEEKEEDKEDETSPK 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flfl	NP_731849.2	PH-like	8..>66	CDD:302622	31/57 (54%)
flfl	NP_731849.2	SMK-1	169..361	CDD:282636	112/191 (59%)
PPP4R3C	NP_997202.3	SMK-1	168..359	CDD:309787	112/191 (59%)
PPP4R3C	NP_997202.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..832		29/137 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	340	1.000	Domainoid score	I1092
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54949
OrthoDB	1	1.010	-	-		D261288at33208
OrthoFinder	1	1.000	-	-		FOG0001376
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101106
Panther	1	1.100	-	-	O	PTHR23318
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X869
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.930