DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment flfl and ppp4r3a

DIOPT Version :9

Sequence 1:	NP_731849.2	Gene:	flfl / 41675	FlyBaseID:	FBgn0024555	Length:	980	Species:	Drosophila melanogaster
Sequence 2:	XP_002933248.1	Gene:	ppp4r3a / 100485426	XenbaseID:	XB-GENE-5858259	Length:	822	Species:	Xenopus tropicalis

Alignment Length:	821	Identity:	448/821 - (54%)
Similarity:	607/821 - (73%)	Gaps:	42/821 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TDTRRRVKLYALNAERQWDDRGTGHVSSTYVERLKGISLLVRAESDGSLLLESKIQPDTAYQKQQ 67
            ||||||||:|.||.:|||||||||||||.|||||||:||||||||||||||||||..:|||||||
Frog     2 TDTRRRVKVYTLNEDRQWDDRGTGHVSSGYVERLKGMSLLVRAESDGSLLLESKINTNTAYQKQQ 66

  Fly    68 DTLIVWSEGDNFDLALSFQEKAGCDEIWEKICQVQGKDPSVEITQDIVEESEDERFEDMSDTAPP 132
            ||||||||.:|:|||||||||||||||||||||||||||||:||||:|:|||:|||:|||  :|.
Frog    67 DTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVDITQDLVDESEEERFDDMS--SPG 129

  Fly   133 IELPPCELSRLEDISETIQSCLSTPLRKEKLSMALESESYIKKLLNLFHVCEDLDNTEGLHHLFE 197
            :|||.|||||||:|:|.:.|.|.:|||:|||::|||:|.||||||.||||||||:|.||||||:|
Frog   130 LELPSCELSRLEEIAEVVASSLPSPLRREKLAVALENEGYIKKLLELFHVCEDLENIEGLHHLYE 194

  Fly   198 IFKNIFLLNKNALFEIMFADDTIFDVVGCLEYDPSVSQPKKHRQYLKQLAKFREAVPIKNLDLLA 262
            |.|.|||||:.||||:||::|.|.|::||||||||:...:|||::|.:.|||:|.:||.:.||..
Frog   195 IIKGIFLLNRTALFEVMFSEDCIMDIIGCLEYDPSLPTQRKHREFLTKTAKFKEVIPISDPDLKQ 259

  Fly   263 KIHQTFRVQYIQDIILPTPSVFVEDNMLNTLSSFIFFNKVEIVTMIQDDERYLLDVFAVLTDPTT 327
            |||||:|||||||::||||||| |:|||:||.|||||||||||.|:|:||::|.::||.|||..|
Frog   260 KIHQTYRVQYIQDVVLPTPSVF-EENMLSTLHSFIFFNKVEIVGMLQEDEKFLTELFAHLTDEAT 323

  Fly   328 GDAKRRDTVLFLKEFCNYAQNLQPQGKDSFYKTLTCLGILQALELTLVMNDKKTKSASIDILTAI 392
            .|.||::.|.||||||.::|.||||.:|:|:|||:.:|||.|||:.|.|:|.:.:||:.||.:.:
Frog   324 DDEKRQELVNFLKEFCAFSQTLQPQNRDAFFKTLSNMGILPALEVILGMDDPQVRSAATDIFSYL 388

  Fly   393 VEFSPLVVRNYTLNQANRPEVERMLLNIAIEQMLNDSEPELGIAVQLMGIVKILLEPENML---- 453
            ||::|.:||.:.:.:|.:.:.:.:|:|:.||.|:.|::||||.||||.|:::.|::|||||
Frog   389 VEYNPSMVREFVMQEAQQNDDDILLINLIIEHMICDTDPELGGAVQLTGLLRTLVDPENMLATTN 453

  Fly   454 -TEKGDFLNFFYKYSVQTLVAPVILNTIGDRPQNEDYQTAQLLGIVLDILSFCVEHHSYHIKNFL 517
             |||.:||.||||:.:..|.||::.||..::|..:|:||||||.::|::|:||||||:|||||::
Frog   454 KTEKTEFLGFFYKHCMHVLTAPLLANTTEEKPSKDDFQTAQLLALILELLTFCVEHHTYHIKNYI 518

  Fly   518 LQKDLLKRILVLMKSTHTFLVLGALRLLRKIIALKDEFYNRHIVKCNLFAPVVDAFIRNNGRYNL 582
            :.||:|:|:||||.|.|:||.|.|||.:|||:.||||||||:|||..||.|||.||:.|..||||
Frog   519 INKDILRRVLVLMSSVHSFLGLCALRFMRKIVGLKDEFYNRYIVKSFLFEPVVKAFLNNGSRYNL 583

  Fly   583 LESAILELFEFIKLEDIRTLCVYFVENFSKIFDEIEYVQTFKYLKNRYDQYQDRLKDRDKMENRT 647
            :.|||||:||:|::|||::|..:.:||:.|..:::|||||||.||.||||.::| :|..|:::..
Frog   584 MNSAILEIFEYIRVEDIKSLTAHVIENYWKALEDVEYVQTFKGLKLRYDQQRER-QDNPKLDSMR 647

  Fly   648 DGGLPIIRSGGRFRRDQRQMEEEEEMWFNEEDDFTEE-----------------IDTYNNVMKSV 695
            .    |:|: .|:|||.|.:|:|||||||.::|..|:                 ||..:..|:..
Frog   648 S----ILRN-HRYRRDARSIEDEEEMWFNTDEDDLEDGEPVVLSSEKIKNSEDLIDPISKFMERK 707

  Fly   696 SEKNGPQTQNQQKSSPPHSTSPHSGLLGSLSTTASSTATSATSGAPVASGS-------SSPEAIS 753
            ..|...:.:...|::.....||...|..|.:|..:.|:.|:.||.|.:.||       .||.::|
Frog   708 KLKESEEKEVLLKTNLTGRQSPSFKLSFSGATKTNLTSQSSASGLPGSPGSPGSPGSPGSPGSVS 772

  Fly   754 ADEQTQAAV----HLAAAALQHHQQQQQQQQQNPFQQQTQP 790
            ......||:    .|..........:::.:..:..:::|.|
Frog   773 KSTPQAAAITTKGGLVGLVDYPDDDEEEDEDDDEEKEETLP 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flfl	NP_731849.2	PH-like	8..>66	CDD:302622	48/57 (84%)
flfl	NP_731849.2	SMK-1	169..361	CDD:282636	124/191 (65%)
ppp4r3a	XP_002933248.1	PH-like	7..>65	CDD:388408	48/57 (84%)
ppp4r3a	XP_002933248.1	SMK-1	166..357	CDD:368128	124/191 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	351	1.000	Domainoid score	I1014
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	882	1.000	Inparanoid score	I395
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D261288at33208
OrthoFinder	1	1.000	-	-		FOG0001376
OrthoInspector	1	1.000	-	-		otm48971
Panther	1	1.100	-	-	O	PTHR23318
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3995
SonicParanoid	1	1.000	-	-		X869
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.190