Protein Alignment omd and INTS5

DIOPT Version :10

• Sequence 1: NP_650303.1
• Gene: omd / 41674
• FlyBaseID: FBgn0038168
• Length: 994
• Species: Drosophila melanogaster
• Sequence 2: NP_085131.1
• Gene: INTS5 / 80789
• HGNCID: 29352
• Length: 1019
• Species: Homo sapiens
• Alignment Length: 1148
• Identity: 269/1148 - (23%)
• Similarity: 404/1148 - (35%)
• Gaps: 322/1148 - (28%)

  Fly     4 QNLLDQLKHFIETVSN--GHSCPQLLTSPNLIKLALGFLEELPATRDIVFEYFALLAEISVQLYV 66
            |.|..::|.|:..|..  ||.    |::....:..|..|..||..|..|.::...:.:.||:.::
Human    29 QELSQEIKAFLTGVDPILGHQ----LSAREHARCGLLLLRSLPPARAAVLDHLRGVFDESVRAHL 89

  Fly    67 S----------PEMADPKTGMPVSQVKLAGNRQQQQRAPEYE-AFNLVKTALQSLVWKGPPAWSP 120
            :          |.:..|    |.|.|...|        |..| ....|:..|...:...|.||:|
Human    90 AALDETPVAGPPHLRPP----PPSHVPAGG--------PGLEDVVQEVQQVLSEFIRANPKAWAP 142

  Fly   121 LIANWSLELVAKLSDKYT---QRRMTITASCN----YWLECSAMHGLMTLINSCFRKLTQPEEEA 178
            :|:.||::|:.:||..|:   ||....|.:.|    .|:.|.|...||.:...|...|.....:|
Human   143 VISAWSIDLMGQLSSTYSGQHQRVPHATGALNELLQLWMGCRATRTLMDIYVQCLSALIGSCPDA 207

  Fly   179 CVEIMLNAFHRFPMTFDWIVARLGGCFPYKIIMQILQCGIKRFVDDYRCH--------------- 228
            ||:.:|:...:....|||:||.:|..||..||.::|.||:|    |:..|
Human   208 CVDALLDTSVQHSPHFDWVVAHIGSSFPGTIISRVLSCGLK----DFCVHGGAGGGAGSSGGSSS 268

  Fly   229 ----------------------LDSEAGILDYMTSCHEQHLRAAFREMLR---------EGFAPK 262
                                  :.|..|||.::.|.|...:|   ||:||         .|....
Human   269 QTPSTDPFPGSPAIPAEKRVPKIASVVGILGHLASRHGDSIR---RELLRMFHDSLAGGSGGRSG 330

  Fly   263 KPLDVAVVPFLLITTNYSDTILQSLVNVLVEIYTEDMCEVIVQKAPLWLS--NKMFAGM-QPTLN 324
            .|...|.|||||.....|..:|.::...||:..          |.|..||  .:...|. :..|:
Human   331 DPSLQATVPFLLQLAVMSPALLGTVSGELVDCL----------KPPAVLSQLQQHLQGFPREELD 385

  Fly   325 NAVLRLNERGATLLLTAAKMAEKYVWCQDFLDNSMQ----------------------------E 361
            | :|.|    |..|::.|..|..|...|..:|.:|.                            .
Human   386 N-MLNL----AVHLVSQASGAGAYRLLQFLVDTAMPASVITTQGLAVPDTVREACDRLIQLLLLH 445

  Fly   362 LEQWVLNQRNFP--------------------------LLADLAYEETKYMLWKSCLSTNLFEQQ 400
            |::.|.::...|                          |..:....|.|..||          |.
Human   446 LQKLVHHRGGSPGEGVLGPPPPPRLVPFLDALKNHVGELCGETLRLERKRFLW----------QH 500

  Fly   401 TAVRLLLVVSSQHPNIYYQTISQLLKKSYAQNPNGIGALIRLLGGQSGMVNFPGFTP-GFKMVLE 464
            ..:.||.|.:  .|:...:.:..||  |.|::|..:....:|..|.  :|:..|..| .|:..|.
Human   501 QLLGLLSVYT--RPSCGPEALGHLL--SRARSPEELSLATQLYAGL--VVSLSGLLPLAFRSCLA 559

  Fly   465 DI---TLDVQVNNRLPVPPGTPTEAFNTFSNLNILARMHKSKNVAPYIKAQHLNQA----LNECL 522
            .:   ||.         ||.|.    ....||.:|....:.....|.....|..::    |::..
Human   560 RVHAGTLQ---------PPFTA----RFLRNLALLVGWEQQGGEGPAALGAHFGESASAHLSDLA 611

  Fly   523 PKILQIFDCTVNKLVLRIDRDAAERIADKFRAQQSKNSNNNNELCNGKDYGKRTKLEPGEDKVDD 587
            |            |:|..:.:.||..|...            .:|....    ..|.|.:
Human   612 P------------LLLHPEEEVAEAAASLL------------AICPFPS----EALSPSQ----- 643

  Fly   588 EDATRMRLAHLIVDLLNNIEAGSRTTVLRTPLVLKLATLSVKYFFVGLTEKTVIRRAAASHRSYT 652
                          ||..:.||                  |..||..|........|:|..
Human   644 --------------LLGLVRAG------------------VHRFFASLRLHGPPGVASACQ---- 672

  Fly   653 LLQRQCSARKIARTVCLRELVERAL------FYHGHLLGQLEVYQLDELEIPEHEHLILQNLHTS 711
            ||.|............|:.|||.||      .:.|.:.|..|...:....:.....|.....||:
Human   673 LLTRLSQTSPAGLKAVLQLLVEGALHRGNTELFGGQVDGDNETLSVVSASLASASLLDTNRRHTA 737

  Fly   712 S--GANSNRSVLHSGIIGRGLRPVLPPSERNCDAEKQALY-----LKALNACC------------ 757
            :  |.....||.|:|:|||||:|......||   :::.:|     |..|..||
Human   738 AVPGPGGIWSVFHAGVIGRGLKPPKFVQSRN---QQEVIYNTQSLLSLLVHCCSAPGGTECGECW 799

  Fly   758 -ADLEKPNNVEGYSLVSLLLVELVSTDVMYNGLPFPDEEFTRVTMERDMLIRRAFINSPVLWAVL 821
             |.:..|   |....|::.|||.|..|.....|.:|.||..|.|:|||:.|.|.|...|:|:.:|
Human   800 GAPILSP---EAAKAVAVTLVESVCPDAAGAELAWPPEEHARATVERDLRIGRRFREQPLLFELL 861

  Fly   822 GLIAGHRPALCYSSVLLRALCATCLHHWRGKNVNRFQPTAANDELML---CTKKMLQLLAMSQLI 883
            .|:|...|||||.|||||.|.|..|.||....    .|...:....|   ||  ::.::|...|:
Human   862 KLVAAAPPALCYCSVLLRGLLAALLGHWEASR----HPDTTHSPWHLEASCT--LVAVMAEGSLL 920

  Fly   884 PPPLTNLHLIIEHFESAEIALLLRECIWNYLKDHVPSPALF-HVDNNGLHWRNTNTQLAKVPPQY 947
            ||.|.|:|.:.......|:.|||.. :|.:|::|.|.|..| .....|...|:.:.:.......:
Human   921 PPALGNMHEVFSQLAPFEVRLLLLS-VWGFLREHGPLPQKFIFQSERGRFIRDFSREGGGEGGPH 984

  Fly   948 VDPLRHLMQRKLSTLGPHYHQMFIMGELMEGDSE-PDPTARLQ 989
            :..|..::.|.:..||           |..|..: |.|:..|:
Human   985 LAVLHSVLHRNIDRLG-----------LFSGRFQAPSPSTLLR 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
omd	NP_650303.1	INTS5_N	4..221	CDD:464341	66/236 (28%)
		INTS5_C	229..962	CDD:464342	194/836 (23%)
INTS5	NP_085131.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		INTS5_N	29..251	CDD:464341	67/241 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	261..283		0/21 (0%)
		INTS5_C	290..999	CDD:464342	194/837 (23%)