DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment omd and ints5

DIOPT Version :9

Sequence 1:	NP_001262542.1	Gene:	omd / 41674	FlyBaseID:	FBgn0038168	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	XP_693062.2	Gene:	ints5 / 564642	ZFINID:	ZDB-GENE-090908-2	Length:	1023	Species:	Danio rerio

Alignment Length:	1136	Identity:	258/1136 - (22%)
Similarity:	439/1136 - (38%)	Gaps:	322/1136 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 QNLLDQLKHFIETVSNGHSCPQLLTSPNLIKLALGFLEELPATRDIVFEYFALLAEISVQLYVSP 68
            |.|..::|.||..|.....  :.|:..:..:.|:..|..:||.|:.|.|:...:.:..|..::..
Zfish    26 QELSLEIKAFISGVDQTQG--RKLSVRDHARCAIRLLRTVPACREAVLEHLRGVYDEYVASFLQD 88

  Fly    69 EMADPKTG---------MPVSQVKLAGNRQQQQRAPEYEAFNLVKTALQSLVWKGPPAWSPLIAN 124
            ..|:.:.|         :.:|.::              :....|...|...:...|.||:||:::
Zfish    89 LEAEGENGGNSASGGASVSISNLE--------------DVIKEVHAVLSEFIKLSPKAWAPLVSS 139

  Fly   125 WSLELVAKLSDKYTQRR-----MTITASCNYWLECSAMHGLMTLINSCFRKLTQPEEEACVEIML 184
            |:::|:.:||.|:..||     .::......|:.|:|...||...:.|...:.....:|||:.:|
Zfish   140 WAVDLLGQLSSKHAGRRAAPHSSSLNELLQLWMSCAATRSLMECYSQCLAAMLAWCPDACVDALL 204

  Fly   185 NAFHRFPMTFDWIVARLGGCFPYKIIMQILQCGIKRFVDDYRCH--------------------- 228
            :...:....|||:||.:|..||..||.::|.||:|    |:..|
Zfish   205 DTSVQHSPHFDWVVAHIGSAFPGTIISRVLACGLK----DFYAHGYSSAEKISQQQAIDKSSRVP 265

  Fly   229 -LDSEAGILDYMTSCHEQHLRAAFREMLRE-----------------GFAPKKPLDVAVVPFLLI 275
             :.|..|||.::.|.|...::.....|.::                 |:.....|..|.|||||.
Zfish   266 KIGSVVGILGHLASRHSDSIKKELLRMFQDSLSVPPQNVPQLTSGAGGWENSPHLRRATVPFLLQ 330

  Fly   276 TTNYSDTILQSLVNVLVEIYTEDMCEVIVQKAPLWLSNKMFAGMQPTLNN----AVLRLNER--- 333
            ....|.|:|.::...|||....   .|::|     |..:..|..:..|.|    ||..:::.
Zfish   331 LAALSPTLLGAVSTELVEFLRP---PVLIQ-----LQAQFQALPREELENMLGLAVHLISQSPSG 387

  Fly   334 GATLLLTAAKMA-------------------EKYVWCQDFLDNSMQELEQWVLNQRN----FPL- 374
            ||.:|...|..|                   |.   |...|...:..|.:.|.|:.:    ||.
Zfish   388 GARVLKFLADTATPSSVIISGPTPSPHDGIREA---CDRLLQMLLLHLHKLVHNRPDGDEPFPQS 449

  Fly   375 -------------------LADLAYE----ETKYMLWKSCLSTNLFEQQTAVRLLLVVSSQH--P 414
                               :|||..|    |.|..||              :..||.:.|.:  |
Zfish   450 STSPAMPQVIPFLEELQAHIADLCAETLRLERKRHLW--------------LHQLLCLLSVYGGP 500

  Fly   415 NIYYQTISQLLKKSYAQNPNGIGALIRLLGGQSGMVNFPGFTPGFKMVLEDITLDVQVNNRLPVP 479
            :|..:.:.||.  :.|:||                              |::.|..|:..:
Zfish   501 SIATEALCQLF--TQARNP------------------------------EELALASQLYTQ---- 529

  Fly   480 PGTPTEAFNTFSNLNILARMHKSKNVAPYIKAQHLNQALNECLPKILQIFDCTVNKLVLRID--- 541
                                              |:.:|:..||.       ||.:.|.:|.
Zfish   530 ----------------------------------LSTSLSGLLPS-------TVARCVAQIHTQT 553

  Fly   542 ---RDAAERIADKFRAQQSKNSNNNNELCNGKDYGKRTKLEPGEDKVDDEDATRMRLAHLIVD-- 601
               ::.|:.:.:...|.||:..       :||:.|..|.......:.......|:.::..:.|
Zfish   554 LDIKELAQLLNNLATAVQSQEE-------DGKNGGGTTTTTGSLTQSSMASEVRVAVSSNLQDFC 611

  Fly   602 -LLNNIEAGSRTTVLR-----------TPL-VLKLATLSVKYFFVGLTEKTVIRRAAASHRSYT- 652
             ||.:.::|.....:|           :|. :|::...:|.:|||.|.::....:|......|:
Zfish   612 PLLLHGDSGVSKAAVRLLSCSQIPRACSPAHLLRICRAAVSHFFVCLRQQGKSPQAGQEEVGYSR 676

  Fly   653 -LLQRQCSARKIARTVCLRELVERALFYHGH--LLGQLEVYQLDELEIPEHEHLILQNLHTSSG- 713
             ||.|..:...:::...|::|||.|| :.|:  |.|.|:       |.|..:....|||....|
Zfish   677 RLLSRLAAYSSLSQKAVLQQLVEGAL-HKGNQDLFGGLQ-------ENPSDDTTQAQNLVPDLGI 733

  Fly   714 --ANSNR-------------SVLHSGIIGRGLRPVLPPSERNCDAEKQAL--YLKALNACC---- 757
              .:.||             ||.|:||||:||:|...|...:.|...|.:  .|..:..||
Zfish   734 SLLDVNRKFGTSVNFSGNVWSVFHAGIIGKGLKPPYTPLHPDPDRVSQNMQTLLAVMVQCCSSSG 798

  Fly   758 ----------------ADLEKPNNVEGYSLVSLLLVELVSTDVMYNGLPFPDEEFTRVTMERDML 806
                            :|...|.|.|...::::.|||.:..||....|.:|.||.::.|:|||:.
Zfish   799 GNPTGSAGSTCSEPNVSDKLPPINAEAAKVIAVTLVENICPDVANGELSWPPEEHSKTTVERDIH 863

  Fly   807 IRRAFINSPVLWAVLGLIAGHRPALCYSSVLLRALCATCLHHWRGKNVNRFQPTAANDELMLCTK 871
            |||.|..:|||:.:|.::|..||||||.||:||||.:|.|.||....    :|:.::....|.|.
Zfish   864 IRRCFEKNPVLFYLLHVVAAGRPALCYCSVILRALLSTLLAHWESSR----EPSVSDSPWHLQTS 924

  Fly   872 -KMLQLLAMSQLIPPPLTNLHLIIEHFESAEIALLLRECIWNYLKDHVPSPALF-HVDNNGLHWR 934
             .::..:...||:||.|:|::.:..|....|:.|||.. :|.|::.:.|.|..| ...:.||.:|
Zfish   925 CWLVSCMGEGQLLPPVLSNINEVFPHLSPFEVRLLLLG-VWEYMRGNSPMPQKFTFCADQGLFFR 988

  Fly   935 --NTNTQLAKVPPQYVDPLRHLMQRKLSTLG 963
              :.:..:|:    |:.|:..::.:.:..||
Zfish   989 DFSRDGDVAR----YIAPIHSVLHKNIDRLG 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
omd	NP_001262542.1	INTS5_N	4..221	CDD:291503	56/230 (24%)
omd	NP_001262542.1	INTS5_C	229..962	CDD:291504	198/872 (23%)
ints5	XP_693062.2	INTS5_N	26..243	CDD:291503	57/236 (24%)
ints5	XP_693062.2	INTS5_C	266..1014	CDD:291504	198/873 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589987
Domainoid	1	1.000	88	1.000	Domainoid score	I7932
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	233	1.000	Inparanoid score	I3396
OMA	1	1.010	-	-		QHG46681
OrthoDB	1	1.010	-	-		D108880at2759
OrthoFinder	1	1.000	-	-		FOG0009533
OrthoInspector	1	1.000	-	-		oto41361
orthoMCL	1	0.900	-	-		OOG6_108361
Panther	1	1.100	-	-	LDO	PTHR31697
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X7278
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910