DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment omd and Ints5

DIOPT Version :9

Sequence 1:	NP_001262542.1	Gene:	omd / 41674	FlyBaseID:	FBgn0038168	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_789813.1	Gene:	Ints5 / 109077	MGIID:	1923578	Length:	1018	Species:	Mus musculus

Alignment Length:	1130	Identity:	263/1130 - (23%)
Similarity:	408/1130 - (36%)	Gaps:	290/1130 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 QNLLDQLKHFIETVSN--GHSCPQLLTSPNLIKLALGFLEELPATRDIVFEYFALLAEISVQLYV 66
            |.|..::|.|:..|..  ||.    |::....:..|..|..||..|..|.::...:.:.||:.::
Mouse    29 QELSQEIKAFLTGVDPILGHQ----LSAREHARCGLLLLRSLPPARAAVLDHLRGVFDESVRAHL 89

  Fly    67 SPEMADPKTG------MPVSQVKLAGNRQQQQRAPEYE-AFNLVKTALQSLVWKGPPAWSPLIAN 124
            :.....|..|      .|.|.|...|        |..| ..:.|:..|...:...|.||:|:|:.
Mouse    90 AALEESPVAGPPHLRPPPPSHVPTGG--------PGLEDVVHEVQQVLCEFIRANPKAWAPVISA 146

  Fly   125 WSLELVAKLSDKYT---QRRMTITASCN----YWLECSAMHGLMTLINSCFRKLTQPEEEACVEI 182
            ||::|:.:||..|:   ||....|.|.|    .|:.|.|...||.:...|...|.....:|||:.
Mouse   147 WSIDLMGQLSSTYSGQHQRVPHATGSLNELLQLWMGCRATRTLMDIYVQCLSALIGSCPDACVDA 211

  Fly   183 MLNAFHRFPMTFDWIVARLGGCFPYKIIMQILQCGIKRFVDDYRCH------------------- 228
            :|:...:....|||:||.:|..||..||.::|.||:|    |:..|
Mouse   212 LLDTSVQHSPHFDWVVAHIGSSFPGTIISRVLSCGLK----DFCVHSGAGGGASACGNSSQPPST 272

  Fly   229 -----------------LDSEAGILDYMTSCHEQHLRAAFREMLR---------EGFAPKKPLDV 267
                             :.|..|||.::.|.|...:|   ||:||         .|....:|...
Mouse   273 DPFPGSPAIPGEKRVPKIASVVGILGHLASRHGDSIR---RELLRMFHDSLAGGSGGRNGEPSLQ 334

  Fly   268 AVVPFLLITTNYSDTILQSLVNVLVEIYTEDMCEVIVQKAPLWLS--NKMFAG-----MQPTLNN 325
            |.|||||.....|..:|.::...||:..          |.|..||  .:...|     :...||.
Mouse   335 ATVPFLLQLAVMSPALLGTVSGELVDCL----------KPPAVLSQLQQHLQGFPREELDNMLNL 389

  Fly   326 AVLRLNERGAT-------LLLTAAKMAEKYVW------------CQDFLDNSMQELEQWVLNQ-- 369
            ||..:::...|       .|:..|..|.....            |...:...:..|::.|.::
Mouse   390 AVHLVSQASGTGAYRLLQFLVDTAMPASVITTQGLAVPDTVREACDRLIQLLLLHLQKLVHHRGG 454

  Fly   370 -------------RNFPLL-------ADLAYE----ETKYMLWKSCLSTNLFEQQTAVRLLLVVS 410
                         |..|.|       .:|..|    |.|..||          |...:.||.|.:
Mouse   455 SPGEGVLGPPPPPRPVPFLDALRNHVGELCGETLRLERKRFLW----------QHQLLGLLSVYT 509

  Fly   411 SQHPNIYYQTISQLLKKSYAQNPNGIGALIRLLGGQSGMVNFPGFTP-GFKMVLEDI---TLDVQ 471
              .|:...:.:..||  |.|::|..:....:|..|.  :|:..|..| .|:..|..:   ||.
Mouse   510 --RPSCGPEALGHLL--SRARSPEELSLATQLYAGL--VVSLSGLLPLAFRSCLARVHAGTLQ-- 566

  Fly   472 VNNRLPVPPGTPTEAFNTFSNLNILARMHKSKNVAPYIKAQHLNQALNECLPKILQIFDCTVNKL 536
                   ||.|.    ....||.:|....:.....|                          :.|
Mouse   567 -------PPFTA----RFLRNLALLVGWEQQGGEGP--------------------------SAL 594

  Fly   537 VLRIDRDAAERIADKFRAQQSKNSNNNNELCNGKDYGKRTKLEP----GEDKVDDEDATRMRLAH 597
            ..|....|:..:||                           |.|    .|::|.:..|:.:.:..
Mouse   595 GARFGESASAHLAD---------------------------LAPLLLHPEEEVAEAAASLLAICP 632

  Fly   598 LIVDLLNNIEAGSRTTVLRTPLVLKLATLSVKYFFVGLTEKTVIRRAAASHRSYTLLQRQCSARK 662
            ...:.|:..:            :|.|....|.:||..|........|:||.    ||.|......
Mouse   633 FPSEALSPSQ------------LLGLVRAGVHHFFSSLRLHGPPGVASASQ----LLTRLSQTSP 681

  Fly   663 IARTVCLRELVERAL------FYHGHLLGQLEVYQLDELEIPEHEHLILQNLHTSS--GANSNRS 719
            ......|:.|||.||      .:.|.:.|..|...:....:.....|.:...||::  |.....|
Mouse   682 AGLKAVLQLLVEGALHRGNTELFGGEMDGDNETLSIVSTPLASASLLDINRRHTAAVPGPGGIWS 746

  Fly   720 VLHSGIIGRGLRPVLPPSERNCDAEKQALY-----LKALNACCA---DLEKPN-------NVEGY 769
            |.|:|:|||||:|......||   .::.:|     :..|..||:   :.|:..       :.|..
Mouse   747 VFHAGVIGRGLKPPKIVQSRN---HQEVIYNTQSLVSLLVHCCSASGNSEREGCWGAPTLSPEAA 808

  Fly   770 SLVSLLLVELVSTDVMYNGLPFPDEEFTRVTMERDMLIRRAFINSPVLWAVLGLIAGHRPALCYS 834
            ..|::.|||.|..|.....|.:|.|:..|.|:|||:.|.|.|...|:|:.:|.|:|...|||||.
Mouse   809 KAVAVTLVESVCPDAAGAELAWPPEDHARATVERDLRIGRRFREQPLLFELLKLVAAAPPALCYC 873

  Fly   835 SVLLRALCATCLHHWRGKNVNRFQPTAANDELMLCTKKMLQLLAMSQLIPPPLTNLHLIIEHFES 899
            |||||.|.|..|.||   ..:|...|..:...:..:..::.::|...|:||.|.|:|.:......
Mouse   874 SVLLRGLLAALLSHW---EASRHPDTTHSPWHLEASCILVAVMAEGSLLPPALGNMHEVFSQLAP 935

  Fly   900 AEIALLLRECIWNYLKDHVPSPALF-HVDNNGLHWRNTNTQLAKVPPQYVDPLRHLMQRKLSTLG 963
            .|:.|||.. :|.:|::|.|.|..| .....|...|:...:.......::..|..::.|.:..||
Mouse   936 FEVRLLLLS-VWGFLREHGPLPQKFIFQSERGRFIRDFAREGGAEGGPHLSVLHSVLHRNIDRLG 999

  Fly   964 PHYHQMFIMGELMEGDSEPDPTARL 988
                       |..|..:..|.:.|
Mouse  1000 -----------LFSGRFQAPPPSTL 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
omd	NP_001262542.1	INTS5_N	4..221	CDD:291503	67/232 (29%)
omd	NP_001262542.1	INTS5_C	229..962	CDD:291504	188/825 (23%)
Ints5	NP_789813.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		INTS5_N	29..251	CDD:291503	68/237 (29%)
		INTS5_C	289..998	CDD:291504	188/826 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845420
Domainoid	1	1.000	87	1.000	Domainoid score	I8021
eggNOG	1	0.900	-	-		E1_28HHP
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	206	1.000	Inparanoid score	I3714
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46681
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009533
OrthoInspector	1	1.000	-	-		oto92813
orthoMCL	1	0.900	-	-		OOG6_108361
Panther	1	1.100	-	-	LDO	PTHR31697
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4370
SonicParanoid	1	1.000	-	-		X7278
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.880