DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lkb1 and Camkk2

DIOPT Version :9

Sequence 1:NP_001163606.1 Gene:Lkb1 / 41673 FlyBaseID:FBgn0038167 Length:567 Species:Drosophila melanogaster
Sequence 2:NP_112628.2 Gene:Camkk2 / 83506 RGDID:620092 Length:587 Species:Rattus norvegicus


Alignment Length:624 Identity:163/624 - (26%)
Similarity:253/624 - (40%) Gaps:168/624 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 CSSSRPVGGKAAGGAEAGGAGATGQMTVTTMEAQVKAAHHHHLHHPTGGGAQHKVEEEEPDPVED 67
            |.||:|...:||...|.|..|                                 |..|...|.| 
  Rat     4 CVSSQPTSDRAAPQDELGSGG---------------------------------VSRESQKPCE- 34

  Fly    68 EMTVL--LANKNFHYDVASDLDDDAFVELKEDTAQADDAGAGVGFYNPDELLLDDQP---HPQVT 127
               .|  |::.:.|      |..::|:.:.|     .:.|.||     |..|..|||   ..|..
  Rat    35 ---ALRGLSSLSIH------LGMESFIVVTE-----CEPGRGV-----DLSLARDQPLEADGQEL 80

  Fly   128 WLDDDEIET-------------------LDRVTLDMG------NMFFNRVDS-QDIIYQQKKKSI 166
            .||..|.|:                   ....:|||.      ::.::...| |......::.::
  Rat    81 PLDASEPESRSLLSGRKMSLQERSQGGPASNSSLDMNGRCICPSLSYSPASSPQSSPRMPRRPTV 145

  Fly   167 K-------------MVGKYIMGDVLGEGSYGKVKEAMNSENLCRLAVKILTKRKL---------- 208
            :             .:.:|.:.|.:|:||||.||.|.|..:....|:|:|:|:||          
  Rat   146 ESHHVSITGLQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRP 210

  Fly   209 -----RRIPNG--------EQNVTREIALLKQLKHRHVVELVDVLYNEEKQKMYLVMEYCVGGLQ 260
                 |..|.|        || |.:|||:||:|.|.:||:||:||.:..:..:|:|.        
  Rat   211 PPRGTRPAPGGCIQPRGPIEQ-VYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVF-------- 266

  Fly   261 EMIDYQPDKRMPLF------QAHGYFKQLVDGLEYLHSCRVIHKDIKPGNLLLSLDQTLKISDFG 319
            |:::..|...:|..      ||..||:.|:.|:||||..::||:||||.|||:..|..:||:|||
  Rat   267 ELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFG 331

  Fly   320 VAEQLDLFAPDDTCTTGQGSPAFQPPE-IANGHETFAGFKVDIWSSGVTLYNLATGQYPFEGDNI 383
            |:.:..  ..|...:...|:|||..|| ::...:.|:|..:|:|:.|||||....||.||..:.|
  Rat   332 VSNEFK--GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERI 394

  Fly   384 YRLLENIGRGQWEAPAWLYEMDADFANLILGMLQADPSKRLSLQEIRHDTWFRSAPVKTGPPIPI 448
            ..|...|.....|.|. ..::..|..:||..||..:|..|:.:.||:...|     |......|:
  Rat   395 MCLHSKIKSQALEFPD-QPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPW-----VTRHGAEPL 453

  Fly   449 PPLKGDKYRNSTVIPYLEAYHYGTQEEDVYFTEHDVNQELARQAAAAASEIRAKQSAAALAACHT 513
            |    .:..|.|::..       |:||    .|:.|     :...:.|:.|..|......:..:.
  Rat   454 P----SEDENCTLVEV-------TEEE----VENSV-----KHIPSLATVILVKTMIRKRSFGNP 498

  Fly   514 YE---PPSTSAAAASNSL-GNGSREEAPVKKKGSALKRR 548
            :|   ....|.:|..|.| ...:||..|:.:...|.:||
  Rat   499 FEGSRREERSLSAPGNLLTKKPTREWEPLSEPKEARQRR 537

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lkb1NP_001163606.1 S_TKc 172..435 CDD:214567 101/292 (35%)
STKc_LKB1 178..435 CDD:271021 99/286 (35%)
Camkk2NP_112628.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..32 11/60 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 74..115 5/40 (13%)
RP domain 203..225 3/21 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 204..224 3/19 (16%)
Autoinhibitory domain. /evidence=ECO:0000250 471..476 2/9 (22%)
Calmodulin-binding. /evidence=ECO:0000250 474..499 4/29 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 496..587 11/42 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D856506at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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