DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkb1 and Prkaa2

DIOPT Version :9

Sequence 1:	NP_001163606.1	Gene:	Lkb1 / 41673	FlyBaseID:	FBgn0038167	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_076481.1	Gene:	Prkaa2 / 78975	RGDID:	620893	Length:	552	Species:	Rattus norvegicus

Alignment Length:	278	Identity:	97/278 - (34%)
Similarity:	158/278 - (56%)	Gaps:	13/278 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 QQKKKSIKMVGKYIMGDVLGEGSYGKVKEAMNSENLCRLAVKILTKRKLRRIPNGEQNVTREIAL 224
            :||......:|.|::||.||.|::||||...:.....::|||||.::|:|.: :....:.|||..
  Rat     4 KQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSL-DVVGKIKREIQN 67

  Fly   225 LKQLKHRHVVELVDVLYNEEKQKMYLVMEYCVGGLQEMIDY-QPDKRMPLFQAHGYFKQLVDGLE 288
            ||..:|.|:::|..|:  ......::||||..||  |:.|| ....|:...:|...|:|::..::
  Rat    68 LKLFRHPHIIKLYQVI--STPTDFFMVMEYVSGG--ELFDYICKHGRVEEVEARRLFQQILSAVD 128

  Fly   289 YLHSCRVIHKDIKPGNLLLSLDQTLKISDFGVAEQLDLFAPDDTCTTGQGSPAFQPPEIANGHET 353
            |.|...|:|:|:||.|:||......||:|||::   ::.:..:...|..|||.:..||:.:| ..
  Rat   129 YCHRHMVVHRDLKPENVLLDAQMNAKIADFGLS---NMMSDGEFLRTSCGSPNYAAPEVISG-RL 189

  Fly   354 FAGFKVDIWSSGVTLYNLATGQYPFEGDNIYRLLENIGRGQWEAPAWLYEMDADFANLILGMLQA 418
            :||.:|||||.||.||.|..|..||:.:::..|.:.|..|.:..|.:|   :...|.|::.|||.
  Rat   190 YAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYL---NRSIATLLMHMLQV 251

  Fly   419 DPSKRLSLQEIRHDTWFR 436
            ||.||.::::||...||:
  Rat   252 DPLKRATIKDIREHEWFK 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	92/263 (35%)
Lkb1	NP_001163606.1	STKc_LKB1	178..435	CDD:271021	89/257 (35%)
Prkaa2	NP_076481.1	STKc_AMPK_alpha	13..268	CDD:270981	93/266 (35%)
		S_TKc	16..268	CDD:214567	92/263 (35%)
		UBA_AID_AAPK2	285..349	CDD:270587
		AIS. /evidence=ECO:0000250	291..376
		AMPKA2_C	395..550	CDD:213385
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	478..520
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910