DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lkb1 and Brsk2

DIOPT Version :9

Sequence 1:	NP_001163606.1	Gene:	Lkb1 / 41673	FlyBaseID:	FBgn0038167	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_001009930.1	Gene:	Brsk2 / 75770	MGIID:	1923020	Length:	719	Species:	Mus musculus

Alignment Length:	282	Identity:	103/282 - (36%)
Similarity:	161/282 - (57%)	Gaps:	14/282 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 VGKYIMGDVLGEGSYGKVKEAMNSENLCRLAVKILTKRKLRRIPNGEQNVTREIALLKQLKHRHV 233
            ||.|.:...||:|..|.||..::.....::|:||:.:.||..  :....|.||||:||.::|.||
Mouse    17 VGPYRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSE--SVLMKVEREIAILKLIEHPHV 79

  Fly   234 VELVDVLYNEEKQKMYLVMEYCVGGLQEMIDYQPDK-RMPLFQAHGYFKQLVDGLEYLHSCRVIH 297
            ::|.||.  |.|:.:|||:|:..||  |:.||...| |:...:|..:|:|::..|::.||..:.|
Mouse    80 LKLHDVY--ENKKYLYLVLEHVSGG--ELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICH 140

  Fly   298 KDIKPGNLLLSLDQTLKISDFGVAEQLDLFAPDDTCTTGQGSPAFQPPEIANGHETFAGFKVDIW 362
            :|:||.||||.....::|:|||:|   .|...|....|..|||.:..||:..| |.:.|.|.|:|
Mouse   141 RDLKPENLLLDERNNIRIADFGMA---SLQVGDSLLETSCGSPHYACPEVIRG-EKYDGRKADVW 201

  Fly   363 SSGVTLYNLATGQYPFEGDNIYRLLENIGRGQWEAPAWLYEMDADFANLILGMLQADPSKRLSLQ 427
            |.||.|:.|..|..||:.||:.:|||.:.||.:..|.::   ..|..:|:.||::.|.::||:|:
Mouse   202 SCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFI---PPDCQSLLRGMIEVDAARRLTLE 263

  Fly   428 EIRHDTWFRSAPVKTGPPIPIP 449
            .|:...|:.....:..|..|||
Mouse   264 HIQKHIWYIGGKNEPEPEQPIP 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	96/263 (37%)
Lkb1	NP_001163606.1	STKc_LKB1	178..435	CDD:271021	95/257 (37%)
Brsk2	NP_001009930.1	STKc_BRSK1_2	18..271	CDD:270983	97/265 (37%)
Brsk2	NP_001009930.1	UBA_BRSK	298..351	CDD:270525
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910