DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkb1 and STK11

DIOPT Version :9

Sequence 1:	NP_001163606.1	Gene:	Lkb1 / 41673	FlyBaseID:	FBgn0038167	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_000446.1	Gene:	STK11 / 6794	HGNCID:	11389	Length:	433	Species:	Homo sapiens

Alignment Length:	424	Identity:	225/424 - (53%)
Similarity:	293/424 - (69%)	Gaps:	23/424 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 FFNRVDSQDIIYQQKKKSIKMVGKYIMGDVLGEGSYGKVKEAMNSENLCRLAVKILTKRKLRRIP 212
            |.:|:||.::|||.::|..|::|||:|||:|||||||||||.::||.|||.|||||.|:||||||
Human    25 FIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIP 89

  Fly   213 NGEQNVTREIALLKQLKHRHVVELVDVLYNEEKQKMYLVMEYCVGGLQEMIDYQPDKRMPLFQAH 277
            |||.||.:||.||::|:|::|::||||||||||||||:||||||.|:|||:|..|:||.|:.|||
Human    90 NGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAH 154

  Fly   278 GYFKQLVDGLEYLHSCRVIHKDIKPGNLLLSLDQTLKISDFGVAEQLDLFAPDDTCTTGQGSPAF 342
            |||.||:||||||||..::|||||||||||:...||||||.||||.|..||.||||.|.||||||
Human   155 GYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAF 219

  Fly   343 QPPEIANGHETFAGFKVDIWSSGVTLYNLATGQYPFEGDNIYRLLENIGRGQWEAPAWLYEMDAD 407
            ||||||||.:||:||||||||:||||||:.||.|||||||||:|.||||:|.:..|.   :....
Human   220 QPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPG---DCGPP 281

  Fly   408 FANLILGMLQADPSKRLSLQEIRHDTWFRSAPVKTGPPIPIPPLKG--DKYRNSTVIPYLEAYHY 470
            .::|:.|||:.:|:||.|:::||..:|||........|:||||...  |::|:.||:||||..|.
Human   282 LSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVVPYLEDLHG 346

  Fly   471 GTQEEDVYFTEHDV--NQE--LARQAAAAASEIRAKQSAAALAACHTYEPPSTSAAAASNSLGNG 531
            ..::||::..|.|:  .|:  :..|.....:....::.....|.|..    .|.||..|......
Human   347 ADEDEDLFDIEDDIIYTQDFTVPGQVPEEEASHNGQRRGLPKAVCMN----GTEAAQLSTKSRAE 407

  Fly   532 SREEAPVKKKGSALKRRAKKLTSCISVRKLSHCR 565
            .|...|.:|..||..:          :|:||.|:
Human   408 GRAPNPARKACSASSK----------IRRLSACK 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	176/262 (67%)
Lkb1	NP_001163606.1	STKc_LKB1	178..435	CDD:271021	172/256 (67%)
STK11	NP_000446.1	Sufficient for interaction with SIRT1. /evidence=ECO:0000269\|PubMed:18687677	45..90		33/44 (75%)
		STKc_LKB1	55..309	CDD:271021	172/256 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..331		5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..433		12/45 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159143
Domainoid	1	1.000	368	1.000	Domainoid score	I920
eggNOG	1	0.900	-	-		E33208_3BA8D
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	441	1.000	Inparanoid score	I1668
Isobase	1	0.950	-	0	Normalized mean entropy	S2228
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D517525at33208
OrthoFinder	1	1.000	-	-		FOG0006218
OrthoInspector	1	1.000	-	-		oto90091
orthoMCL	1	0.900	-	-		OOG6_104622
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2709
SonicParanoid	1	1.000	-	-		X5157
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.640