DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lkb1 and STK11

DIOPT Version :10

Sequence 1:NP_650302.1 Gene:Lkb1 / 41673 FlyBaseID:FBgn0038167 Length:567 Species:Drosophila melanogaster
Sequence 2:NP_000446.1 Gene:STK11 / 6794 HGNCID:11389 Length:433 Species:Homo sapiens


Alignment Length:424 Identity:225/424 - (53%)
Similarity:293/424 - (69%) Gaps:23/424 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly   148 FFNRVDSQDIIYQQKKKSIKMVGKYIMGDVLGEGSYGKVKEAMNSENLCRLAVKILTKRKLRRIP 212
            |.:|:||.::|||.::|..|::|||:|||:|||||||||||.::||.|||.|||||.|:||||||
Human    25 FIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIP 89

  Fly   213 NGEQNVTREIALLKQLKHRHVVELVDVLYNEEKQKMYLVMEYCVGGLQEMIDYQPDKRMPLFQAH 277
            |||.||.:||.||::|:|::|::||||||||||||||:||||||.|:|||:|..|:||.|:.|||
Human    90 NGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAH 154

  Fly   278 GYFKQLVDGLEYLHSCRVIHKDIKPGNLLLSLDQTLKISDFGVAEQLDLFAPDDTCTTGQGSPAF 342
            |||.||:||||||||..::|||||||||||:...||||||.||||.|..||.||||.|.||||||
Human   155 GYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAF 219

  Fly   343 QPPEIANGHETFAGFKVDIWSSGVTLYNLATGQYPFEGDNIYRLLENIGRGQWEAPAWLYEMDAD 407
            ||||||||.:||:||||||||:||||||:.||.|||||||||:|.||||:|.:..|.   :....
Human   220 QPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPG---DCGPP 281

  Fly   408 FANLILGMLQADPSKRLSLQEIRHDTWFRSAPVKTGPPIPIPPLKG--DKYRNSTVIPYLEAYHY 470
            .::|:.|||:.:|:||.|:::||..:|||........|:||||...  |::|:.||:||||..|.
Human   282 LSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVVPYLEDLHG 346

  Fly   471 GTQEEDVYFTEHDV--NQE--LARQAAAAASEIRAKQSAAALAACHTYEPPSTSAAAASNSLGNG 531
            ..::||::..|.|:  .|:  :..|.....:....::.....|.|..    .|.||..|......
Human   347 ADEDEDLFDIEDDIIYTQDFTVPGQVPEEEASHNGQRRGLPKAVCMN----GTEAAQLSTKSRAE 407

  Fly   532 SREEAPVKKKGSALKRRAKKLTSCISVRKLSHCR 565
            .|...|.:|..||..:          :|:||.|:
Human   408 GRAPNPARKACSASSK----------IRRLSACK 431

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lkb1NP_650302.1 STKc_LKB1 178..435 CDD:271021 172/256 (67%)
STK11NP_000446.1 Sufficient for interaction with SIRT1. /evidence=ECO:0000269|PubMed:18687677 45..90 33/44 (75%)
STKc_LKB1 55..309 CDD:271021 172/256 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 312..331 5/18 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 397..433 12/45 (27%)

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