DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkb1 and Prkaa1

DIOPT Version :9

Sequence 1:	NP_001163606.1	Gene:	Lkb1 / 41673	FlyBaseID:	FBgn0038167	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_062015.2	Gene:	Prkaa1 / 65248	RGDID:	3387	Length:	559	Species:	Rattus norvegicus

Alignment Length:	278	Identity:	99/278 - (35%)
Similarity:	161/278 - (57%)	Gaps:	13/278 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 QQKKKSIKMVGKYIMGDVLGEGSYGKVKEAMNSENLCRLAVKILTKRKLRRIPNGEQNVTREIAL 224
            :||......:|.||:||.||.|::||||...:.....::|||||.::|:|.: :....:.|||..
  Rat    15 KQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSL-DVVGKIRREIQN 78

  Fly   225 LKQLKHRHVVELVDVLYNEEKQKMYLVMEYCVGGLQEMIDY-QPDKRMPLFQAHGYFKQLVDGLE 288
            ||..:|.|:::|..|:  .....:::||||..||  |:.|| ..:.|:...::...|:|::.|::
  Rat    79 LKLFRHPHIIKLYQVI--STPSDIFMVMEYVSGG--ELFDYICKNGRLDEKESRRLFQQILSGVD 139

  Fly   289 YLHSCRVIHKDIKPGNLLLSLDQTLKISDFGVAEQLDLFAPDDTCTTGQGSPAFQPPEIANGHET 353
            |.|...|:|:|:||.|:||......||:|||::   ::.:..:...|..|||.:..||:.:| ..
  Rat   140 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS---NMMSDGEFLRTSCGSPNYAAPEVISG-RL 200

  Fly   354 FAGFKVDIWSSGVTLYNLATGQYPFEGDNIYRLLENIGRGQWEAPAWLYEMDADFANLILGMLQA 418
            :||.:||||||||.||.|..|..||:.|::..|.:.|..|.:..|.:|   :....:|:..|||.
  Rat   201 YAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYL---NPSVISLLKHMLQV 262

  Fly   419 DPSKRLSLQEIRHDTWFR 436
            ||.||.::::||...||:
  Rat   263 DPMKRATIKDIREHEWFK 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	94/263 (36%)
Lkb1	NP_001163606.1	STKc_LKB1	178..435	CDD:271021	90/257 (35%)
Prkaa1	NP_062015.2	STKc_AMPK_alpha	24..279	CDD:270981	95/266 (36%)
		UBA_AID_AAPK1	296..360	CDD:270586
		AIS. /evidence=ECO:0000250	302..381
		AMPKA1_C	404..557	CDD:213384
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	484..536
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910