DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkb1 and Camkk1

DIOPT Version :9

Sequence 1:	NP_001163606.1	Gene:	Lkb1 / 41673	FlyBaseID:	FBgn0038167	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_113850.1	Gene:	Camkk1 / 60341	RGDID:	62023	Length:	505	Species:	Rattus norvegicus

Alignment Length:	346	Identity:	109/346 - (31%)
Similarity:	180/346 - (52%)	Gaps:	56/346 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 DSQDIIYQQKKKSIKMVGKYIMGDVLGEGSYGKVKEAMNSENLCRLAVKILTKRKL--------R 209
            |::|.:         .:.:|.:...:|:|:||.|:.|.|.......|:|:|:|:||        |
  Rat   118 DTEDCV---------QLNQYKLQSEIGKGAYGVVRLAYNEREDRHYAMKVLSKKKLLKQYGFPRR 173

  Fly   210 RIPNGEQ--------------NVTREIALLKQLKHRHVVELVDVLYNEEKQKMYLVMEYCVGGLQ 260
            ..|.|.|              .|.:|||:||:|.|.:||:|::||.:..:..:|||.:....|
  Rat   174 PPPRGSQAPQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKG-- 236

  Fly   261 EMIDYQPDKRMPLFQAHGYFKQLVDGLEYLHSCRVIHKDIKPGNLLLSLDQTLKISDFGVAEQLD 325
            .:::...||..|..||..|.:.::.||||||..:::|:||||.||||..|..:||:||||:.|.:
  Rat   237 PVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE 301

  Fly   326 LFAPDDTCTTGQGSPAFQPPE-IANGHETFAGFKVDIWSSGVTLYNLATGQYPFEGDNI---YRL 386
              ..|...::..|:|||..|| |::..::|:|..:|:|::|||||....|:.||..:.|   :|.
  Rat   302 --GNDAQLSSTAGTPAFMAPEAISDTGQSFSGKALDVWATGVTLYCFVYGKCPFIDEYILALHRK 364

  Fly   387 LENIGRGQWEAPAWLYEMDADFANLILGMLQADPSKRLSLQEIRHDTWFRSAPVKTG-PPIP--- 447
            ::|......|.|    |:..:..:|||.||..:|..|:.:.:|:...|.    .|.| .|:|
  Rat   365 IKNEAVVFPEEP----EVSEELKDLILKMLDKNPETRIGVSDIKLHPWV----TKHGEEPLPSEE 421

  Fly   448 ----IPPLKGDKYRNST-VIP 463
                :..:..::.:||. :||
  Rat   422 EHCSVVEVTEEEVKNSVKLIP 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	98/288 (34%)
Lkb1	NP_001163606.1	STKc_LKB1	178..435	CDD:271021	97/282 (34%)
Camkk1	NP_113850.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..66
		PKc_like	127..410	CDD:304357	99/294 (34%)
		S_TKc	128..409	CDD:214567	98/288 (34%)
		RP domain. /evidence=ECO:0000269\|PubMed:10336483	167..189		4/21 (19%)
		Autoinhibitory domain. /evidence=ECO:0000269\|PubMed:10336483, ECO:0000269\|PubMed:9335539	435..440		2/4 (50%)
		Calmodulin-binding. /evidence=ECO:0000269\|PubMed:10467092, ECO:0000269\|PubMed:9335539	438..463		2/5 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	460..505
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910