DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkb1 and mark2

DIOPT Version :9

Sequence 1:	NP_001163606.1	Gene:	Lkb1 / 41673	FlyBaseID:	FBgn0038167	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	XP_012808991.1	Gene:	mark2 / 594939	XenbaseID:	XB-GENE-876451	Length:	792	Species:	Xenopus tropicalis

Alignment Length:	431	Identity:	124/431 - (28%)
Similarity:	203/431 - (47%)	Gaps:	81/431 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 VGKYIMGDVLGEGSYGKVKEAMNSENLCRLAVKILTKRKLRRIPNGEQNVTREIALLKQLKHRHV 233
            :|.|.:...:|:|::.|||.|.:......:||||:.|.:|.  .:..|.:.||:.::|.|.|.::
Frog    61 IGNYRLLKTIGKGNFAKVKLARHVLTGKEVAVKIIDKTQLN--SSSLQKLFREVRIMKVLNHPNI 123

  Fly   234 VELVDVLYNEEKQKMYLVMEYCVGGLQEMIDY-QPDKRMPLFQAHGYFKQLVDGLEYLHSCRVIH 297
            |:|.:|:  |.::.:||||||..||  |:.|| ....||...:|...|:|:|..::|.|...::|
Frog   124 VKLFEVI--ETEKTLYLVMEYASGG--EVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKLIVH 184

  Fly   298 KDIKPGNLLLSLDQTLKISDFGVAEQ------LDLFAPDDTCTTGQGSPAFQPPEIANGHETFAG 356
            :|:|..||||..|..:||:|||.:.:      ||.|.         |||.:..||:..| :.:.|
Frog   185 RDLKAENLLLDSDMNIKIADFGFSNEFTFGNKLDTFC---------GSPPYAAPELFQG-KKYDG 239

  Fly   357 FKVDIWSSGVTLYNLATGQYPFEGDNIYRLLENIGRGQWEAPAWLYEMDADFANLILGMLQADPS 421
            .:||:||.||.||.|.:|..||:|.|:..|.|.:.||::..|   :.|..|..||:...|..:|:
Frog   240 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIP---FYMSTDCENLLKKFLILNPA 301

  Fly   422 KRLSLQEIRHDTWFRSAPVKTG-------PPI-PIPPLK-----------------------GDK 455
            ||.:|::|..|.|     :..|       |.: |||..|                       ..|
Frog   302 KRGTLEQIMRDRW-----MNVGHEEDELKPYVEPIPDYKDPKRTELMITMGYTREEISDSLVNQK 361

  Fly   456 YRNSTVIPYLEAYHYGTQEEDVYFT-----EHDVNQELA--------RQAAAAASEIR-AKQSAA 506
            | |..:..||...:..::.::...|     ..||...:|        |..:|...:.| :.|:..
Frog   362 Y-NEVMATYLLLGYKSSETDNDNLTLKPRPPPDVTNSIAPSPAHKVQRSVSANPKQRRLSDQAGP 425

  Fly   507 ALAACHTYEPPSTSAAAASNSLGNGSREEAPVKKKGSALKR 547
            |:...::|...:.|    :|:....|.::....:|.|:..|
Frog   426 AIPNSNSYSKKTQS----NNAENRRSEDDKESGRKSSSTVR 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	95/269 (35%)
Lkb1	NP_001163606.1	STKc_LKB1	178..435	CDD:271021	94/263 (36%)
mark2	XP_012808991.1	STKc_MARK	63..315	CDD:270974	96/275 (35%)
		UBA_MARK2	333..374	CDD:270589	6/41 (15%)
		MARK2_C	693..791	CDD:213386
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910