DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lkb1 and Sik1

DIOPT Version :9

Sequence 1:	NP_001163606.1	Gene:	Lkb1 / 41673	FlyBaseID:	FBgn0038167	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_067725.2	Gene:	Sik1 / 59329	RGDID:	69407	Length:	776	Species:	Rattus norvegicus

Alignment Length:	405	Identity:	111/405 - (27%)
Similarity:	190/405 - (46%)	Gaps:	57/405 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 QQKKKSIKMVGKYIMGDVLGEGSYGKVKEAMNSENLCRLAVKILTKRKLRRIPNGEQNVTREIAL 224
            |.::|.:: ||.|.:...||:|::..||.|.:.....::|:||:.|.:|.  .:..:.:.||:.|
  Rat    16 QGQQKPLR-VGFYDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLD--SSNLEKIYREVQL 77

  Fly   225 LKQLKHRHVVELVDVLYNEEKQKMYLVMEYCVGGLQEMIDY-QPDKRMPLFQAHGYFKQLVDGLE 288
            :|.|.|.::::|..|:  |.|..:|:|.|:...|  ||.|| ..:..:...:|...|.|::..:|
  Rat    78 MKLLNHPNIIKLYQVM--ETKDMLYIVTEFAKNG--EMFDYLTSNGHLSENEARKKFWQILSAVE 138

  Fly   289 YLHSCRVIHKDIKPGNLLLSLDQTLKISDFGVAEQLDLFAPDDTCTTGQGSPAFQPPEIANGHET 353
            |.|:..::|:|:|..||||..:..:|::|||..   :.:.|.:..:|..|||.:..||:..|.|
  Rat   139 YCHNHHIVHRDLKTENLLLDGNMDIKLADFGFG---NFYKPGEPLSTWCGSPPYAAPEVFEGKE- 199

  Fly   354 FAGFKVDIWSSGVTLYNLATGQYPFEGDNIYRLLENIGRGQWEAPAWLYEMDADFANLILGMLQA 418
            :.|.::||||.||.||.|..|..||:|.|:..|.:.:..|::..|   :.|..|...||..||..
  Rat   200 YEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIP---FFMSQDCETLIRRMLVV 261

  Fly   419 DPSKRLSLQEIRHDTWFRSAPVKTGPPIPIPPLKG---------------------DKYRNSTVI 462
            ||:||:::.:||...|.::.|.......|...::|                     |:.|....:
  Rat   262 DPAKRITIAQIRQHRWMQADPTLLQQDDPAFSMQGYTSNLGDYNEQVLGIMQALGIDRQRTVESL 326

  Fly   463 PYLEAYHYGTQEEDVYF------TEHDVNQELARQAAAAA-------SEIRAKQSAAALAACHTY 514
            ......|:..    :|:      .||...|..:|...|.|       |::.:.:....:..|..:
  Rat   327 QNSSYNHFAA----IYYLLLERLREHRSTQPSSRATPAPARQPQLRNSDLSSLEVPQEILPCDPF 387

  Fly   515 EP----PSTSAAAAS 525
            .|    |...|.|.|
  Rat   388 RPSLLCPQPQALAQS 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	86/263 (33%)
Lkb1	NP_001163606.1	STKc_LKB1	178..435	CDD:271021	85/257 (33%)
Sik1	NP_067725.2	STKc_SIK	26..278	CDD:270973	86/264 (33%)
		UBA_SIK1	300..349	CDD:270591	5/52 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	350..371		4/20 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..472
		RK-rich region. /evidence=ECO:0000250	586..612
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	621..643
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910