DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkb1 and mark4b

DIOPT Version :9

Sequence 1:	NP_001163606.1	Gene:	Lkb1 / 41673	FlyBaseID:	FBgn0038167	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	XP_005157655.1	Gene:	mark4b / 571279	ZFINID:	ZDB-GENE-100330-2	Length:	796	Species:	Danio rerio

Alignment Length:	391	Identity:	117/391 - (29%)
Similarity:	191/391 - (48%)	Gaps:	63/391 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 VGKYIMGDVLGEGSYGKVKEAMNSENLCRLAVKILTKRKLRRIPNGEQNVTREIALLKQLKHRHV 233
            :|.|.:...:|:|::.|||.|.:......:|:||:.|.:|.  |...|.:.||:.::|.|.|.::
Zfish    55 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLN--PTSLQKLFREVRIMKGLNHPNI 117

  Fly   234 VELVDVLYNEEKQKMYLVMEYCVGGLQEMIDYQPDK-RMPLFQAHGYFKQLVDGLEYLHSCRVIH 297
            |:|.:|:  |.::.:||||||..||  |:.||.... ||...:|.|.|:|:|..:.|.|...::|
Zfish   118 VQLFEVI--ETEKTLYLVMEYASGG--EVFDYLVSHGRMKEKEARGKFRQIVSAVHYCHLKNIVH 178

  Fly   298 KDIKPGNLLLSLDQTLKISDFGVAEQLDLFAPDDT-CTTGQGSPAFQPPEIANGHETFAGFKVDI 361
            :|:|..||||..|..:||:|||.:.:..|.:..|| |    |||.:..||:..| :.:.|.:|||
Zfish   179 RDLKAENLLLDADSNIKIADFGFSNEFTLGSKLDTFC----GSPPYAAPELFQG-KKYDGPEVDI 238

  Fly   362 WSSGVTLYNLATGQYPFEGDNIYRLLENIGRGQWEAPAWLYEMDADFANLILGMLQADPSKRLSL 426
            ||.||.||.|.:|..||:|.|:..|.|.:.||::..|   :.|..|...::...|..:|:||.:|
Zfish   239 WSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRVP---FYMSTDCEGILRRFLVLNPTKRCTL 300

  Fly   427 QEIRHDTWFRSAPVKTGPPIPIPPLKGDKYRNSTVIPYLEAY--HYGTQEEDVY----FTEHDVN 485
            ::|..|.|....                 |.|..:.||:|..  :..|...||.    ::..::.
Zfish   301 EQIMKDKWMNVG-----------------YENDELKPYIEPVEDYNDTSRVDVMVGMGYSRDEIK 348

  Fly   486 QELARQ-----------------------AAAAASEIRAKQSAAALAAC-HTYEPPSTSAAAASN 526
            ..|..|                       ::::.|..|.:.||...... |:....|:|.:|:|:
Zfish   349 DALTTQKYNEIFATYLLLGRKNEDGMESRSSSSLSLARVRPSAITNGTSKHSSTSSSSSTSASSH 413

  Fly   527 S 527
            :
Zfish   414 T 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	96/264 (36%)
Lkb1	NP_001163606.1	STKc_LKB1	178..435	CDD:271021	95/258 (37%)
mark4b	XP_005157655.1	STKc_MARK	57..309	CDD:270974	96/265 (36%)
		S_TKc	58..309	CDD:214567	96/264 (36%)
		UBA_like_SF	327..369	CDD:304366	5/41 (12%)
		MARK4_C	699..796	CDD:213382
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910