DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkb1 and brsk1a

DIOPT Version :9

Sequence 1:	NP_001163606.1	Gene:	Lkb1 / 41673	FlyBaseID:	FBgn0038167	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	XP_693123.4	Gene:	brsk1a / 564701	ZFINID:	ZDB-GENE-121214-354	Length:	746	Species:	Danio rerio

Alignment Length:	286	Identity:	101/286 - (35%)
Similarity:	161/286 - (56%)	Gaps:	17/286 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 KSIKMVGKYIMGDVLGEGSYGKVKEAMNSENLCRLAVKILTKRKLRRIPNGEQNVTREIALLKQL 228
            ::.:.||.|.:...||:|..|.||..::.....::|:||:.:.||..  :....|.||||:||.:
Zfish     9 QAAQYVGPYRLEKTLGKGQTGLVKLGIHCITSQKVAIKIVNREKLSE--SVLMKVEREIAILKLI 71

  Fly   229 KHRHVVELVDVLYNEEKQKMYLVMEYCVGGLQEMIDYQPDK-RMPLFQAHGYFKQLVDGLEYLHS 292
            :|.||::|.||.  |..:.:|||:|:..||  |:.||...| |:...:|..:|:|::..|::.||
Zfish    72 EHPHVLKLHDVY--ENNKYLYLVLEHVSGG--ELFDYLVKKGRLTPKEARKFFRQIISALDFCHS 132

  Fly   293 CRVIHKDIKPGNLLLSLDQTLKISDFGVAEQLDLFAPDDTCTTGQGSPAFQPPEIANGHETFAGF 357
            ..:.|:|:||.||||.....::|:|||:|   .|...|....|..|||.:..||:..| |.:.|.
Zfish   133 HSICHRDLKPENLLLDERNNIRIADFGMA---SLQVGDSLLETSCGSPHYACPEVIRG-EKYDGR 193

  Fly   358 KVDIWSSGVTLYNLATGQYPFEGDNIYRLLENIGRGQWEAPAWLYEMDADFANLILGMLQADPSK 422
            :.|:||.||.|:.|..|..||:.||:.:|||.:..|.:..|.::   ..|...|:.||::.:|.|
Zfish   194 RADVWSCGVILFALLVGALPFDHDNLRQLLEKVKSGVFHMPHFI---PPDCQALLRGMIEVNPEK 255

  Fly   423 RLSLQEIRHDTWF---RSAPVKTGPP 445
            ||:|:.|:...|:   |:.|....||
Zfish   256 RLTLEAIQKHAWYQAGRNEPCPEQPP 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	94/263 (36%)
Lkb1	NP_001163606.1	STKc_LKB1	178..435	CDD:271021	93/257 (36%)
brsk1a	XP_693123.4	STKc_BRSK1_2	15..268	CDD:270983	95/265 (36%)
		S_TKc	17..267	CDD:214567	94/262 (36%)
		UBA_BRSK	295..348	CDD:270525
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910