DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkb1 and mark2a

DIOPT Version :9

Sequence 1:	NP_001163606.1	Gene:	Lkb1 / 41673	FlyBaseID:	FBgn0038167	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	XP_009293774.1	Gene:	mark2a / 562231	ZFINID:	ZDB-GENE-030131-4145	Length:	782	Species:	Danio rerio

Alignment Length:	452	Identity:	124/452 - (27%)
Similarity:	206/452 - (45%)	Gaps:	95/452 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 VGKYIMGDVLGEGSYGKVKEAMNSENLCRLAVKILTKRKLRRIPNGEQNVTREIALLKQLKHRHV 233
            :|.|.:...:|:|::.|||.|.:......:||||:.|.:|.  .:..|.:.||:.::|.|.|.::
Zfish    41 IGCYRLLKTIGKGNFAKVKLAKHILTGKEVAVKIIDKTQLN--SSSLQKLFREVRIMKLLNHPNI 103

  Fly   234 VELVDVLYNEEKQKMYLVMEYCVGGLQEMIDY-QPDKRMPLFQAHGYFKQLVDGLEYLHSCRVIH 297
            |:|.:|:  |.::.:||||||..||  |:.|| ....||...:|...|:|:|..::|.|...::|
Zfish   104 VKLFEVI--ETEKTLYLVMEYASGG--EVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVH 164

  Fly   298 KDIKPGNLLLSLDQTLKISDFGVAEQLDLFAPDDT-CTTGQGSPAFQPPEIANGHETFAGFKVDI 361
            :|:|..||||..|..:||:|||.:.:..|....|| |    |||.:..||:..| :.:.|.:||:
Zfish   165 RDLKAENLLLDADMNIKIADFGFSNEFTLGNKLDTFC----GSPPYAAPELFQG-KKYDGPEVDV 224

  Fly   362 WSSGVTLYNLATGQYPFEGDNIYRLLENIGRGQWEAPAWLYEMDADFANLILGMLQADPSKRLSL 426
            ||.||.||.|.:|..||:|.|:..|.|.:.||::..|   :.|..|..||:...|..:|:||.||
Zfish   225 WSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIP---FYMSTDCENLLKKFLVLNPTKRGSL 286

  Fly   427 -QEIRHDTWFR------------------SAPVKTGP-PIPIPPLKGD----------------- 454
             |:|..|.|..                  ..|.:||. |......|.|
Zfish   287 EQQIMKDRWMNVGHEDEELKPYIEPQPDYKDPKRTGQHPSSAGGWKRDIMIRMGYSLDEIQDSLI 351

  Fly   455 --KYRNSTVIPYLEAYHYGTQEEDVYFTEH---DVN---QELARQAAAAASEIRAKQS------- 504
              || |..:..||...:..::.:::.....   |:.   |..:.:...:.|.:::::|
Zfish   352 NQKY-NDVMATYLLLDYRNSELDELSIKARPGTDITNNAQSPSHKGQRSTSNLKSRRSTDQSSVS 415

  Fly   505 ----------------------AAALAACHTYEP-PSTSAAAASNSLGNGSREEAPVKKKGS 543
                                  :..::..|...| |||::..:|   |.|....:|:.::.:
Zfish   416 SKRPQGDSKHIGSSGSSSKVPPSPLISGDHKKTPTPSTNSILSS---GTGRSRNSPITERAT 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	98/265 (37%)
Lkb1	NP_001163606.1	STKc_LKB1	178..435	CDD:271021	97/259 (37%)
mark2a	XP_009293774.1	STKc_MARK	44..296	CDD:270974	98/265 (37%)
		S_TKc	44..296	CDD:214567	98/265 (37%)
		UBA_MARK2	314..367	CDD:270589	11/53 (21%)
		MARK2_C	683..781	CDD:213386
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910