DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lkb1 and brsk1b

DIOPT Version :9

Sequence 1:	NP_001163606.1	Gene:	Lkb1 / 41673	FlyBaseID:	FBgn0038167	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	XP_009297839.1	Gene:	brsk1b / 558390	ZFINID:	ZDB-GENE-131122-54	Length:	862	Species:	Danio rerio

Alignment Length:	286	Identity:	101/286 - (35%)
Similarity:	161/286 - (56%)	Gaps:	17/286 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 KSIKMVGKYIMGDVLGEGSYGKVKEAMNSENLCRLAVKILTKRKLRRIPNGEQNVTREIALLKQL 228
            ::.:.||.|.:...||:|..|.||..::.....::|:||:.:.||..  :....|.||||:||.:
Zfish    10 QAAQYVGPYRLEKTLGKGQTGLVKLGVHCITTQKVAIKIVNREKLSE--SVLMKVEREIAILKLI 72

  Fly   229 KHRHVVELVDVLYNEEKQKMYLVMEYCVGGLQEMIDYQPDK-RMPLFQAHGYFKQLVDGLEYLHS 292
            :|.||::|.||.  |..:.:|||:|:..||  |:.||...| |:...:|..:|:|::..|::.||
Zfish    73 EHPHVLKLYDVY--ENNKYLYLVLEHVSGG--ELFDYLVKKGRLTPKEARKFFRQIISALDFCHS 133

  Fly   293 CRVIHKDIKPGNLLLSLDQTLKISDFGVAEQLDLFAPDDTCTTGQGSPAFQPPEIANGHETFAGF 357
            ..:.|:|:||.||||.....::|:|||:|   .|...|....|..|||.:..||:..| |.:.|.
Zfish   134 HSICHRDLKPENLLLDEKNNIRIADFGMA---SLQVGDSLLETSCGSPHYACPEVIRG-EKYDGR 194

  Fly   358 KVDIWSSGVTLYNLATGQYPFEGDNIYRLLENIGRGQWEAPAWLYEMDADFANLILGMLQADPSK 422
            :.|:||.||.|:.|..|..||:.||:.:|||.:..|.:..|.::   ..|...|:.||::.:..|
Zfish   195 RADVWSCGVILFALLVGALPFDHDNLRQLLEKVKSGVFHMPHFI---PPDCQALLRGMIEVNAEK 256

  Fly   423 RLSLQEIRHDTWF---RSAPVKTGPP 445
            ||:|:||:...|:   |:.|....||
Zfish   257 RLTLEEIQKHPWYQGGRNEPCPEQPP 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	94/263 (36%)
Lkb1	NP_001163606.1	STKc_LKB1	178..435	CDD:271021	93/257 (36%)
brsk1b	XP_009297839.1	STKc_BRSK1_2	16..269	CDD:270983	95/265 (36%)
		S_TKc	18..268	CDD:214567	94/262 (36%)
		UBA_BRSK	296..349	CDD:270525
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910