DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkb1 and PRKAA1

DIOPT Version :9

Sequence 1:	NP_001163606.1	Gene:	Lkb1 / 41673	FlyBaseID:	FBgn0038167	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_996790.3	Gene:	PRKAA1 / 5562	HGNCID:	9376	Length:	574	Species:	Homo sapiens

Alignment Length:	293	Identity:	100/293 - (34%)
Similarity:	162/293 - (55%)	Gaps:	28/293 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 QQKKKSIKMVGKYIMGDVLGEGSYGKVKEAMNSENLCRLAVKILTKRKLRRIPNGEQNVTREIAL 224
            :||......:|.||:||.||.|::||||...:.....::|||||.::|:|.: :....:.|||..
Human    15 KQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSL-DVVGKIRREIQN 78

  Fly   225 LKQLKHRHVVELVDVLYNEEKQKMYLVMEYCVGGLQEMIDY------QPD----------KRMPL 273
            ||..:|.|:::|..|:  .....:::||||..||  |:.||      :.|          |.:..
Human    79 LKLFRHPHIIKLYQVI--STPSDIFMVMEYVSGG--ELFDYICKNGRKSDVPGVVKTGSTKELDE 139

  Fly   274 FQAHGYFKQLVDGLEYLHSCRVIHKDIKPGNLLLSLDQTLKISDFGVAEQLDLFAPDDTCTTGQG 338
            .::...|:|::.|::|.|...|:|:|:||.|:||......||:|||::   ::.:..:...|..|
Human   140 KESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS---NMMSDGEFLRTSCG 201

  Fly   339 SPAFQPPEIANGHETFAGFKVDIWSSGVTLYNLATGQYPFEGDNIYRLLENIGRGQWEAPAWLYE 403
            ||.:..||:.:| ..:||.:||||||||.||.|..|..||:.|::..|.:.|..|.:..|.:|
Human   202 SPNYAAPEVISG-RLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYL-- 263

  Fly   404 MDADFANLILGMLQADPSKRLSLQEIRHDTWFR 436
             :....:|:..|||.||.||.::::||...||:
Human   264 -NPSVISLLKHMLQVDPMKRATIKDIREHEWFK 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	95/278 (34%)
Lkb1	NP_001163606.1	STKc_LKB1	178..435	CDD:271021	91/272 (33%)
PRKAA1	NP_996790.3	STKc_AMPK_alpha	24..294	CDD:270981	96/281 (34%)
		UBA_AID_AAPK1	311..375	CDD:270586
		AMPKA1_C	419..572	CDD:213384
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910