DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkb1 and stk11

DIOPT Version :9

Sequence 1:	NP_001163606.1	Gene:	Lkb1 / 41673	FlyBaseID:	FBgn0038167	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_001017839.1	Gene:	stk11 / 550537	ZFINID:	ZDB-GENE-050417-383	Length:	440	Species:	Danio rerio

Alignment Length:	448	Identity:	237/448 - (52%)
Similarity:	306/448 - (68%)	Gaps:	30/448 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 EIETLDRVTLD--MG-NMFFNRVDSQDIIYQQKKKSIKMVGKYIMGDVLGEGSYGKVKEAMNSEN 194
            :::.||.:|.:  || :.|.:|:||.::|||.::|..|::|||:|||:|||||||||||.::.|.
Zfish     6 DLQHLDYLTENELMGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSYGKVKEMLDPET 70

  Fly   195 LCRLAVKILTKRKLRRIPNGEQNVTREIALLKQLKHRHVVELVDVLYNEEKQKMYLVMEYCVGGL 259
            |||.|||||.|:|||||||||.||.:||.||::|:|::|::||||||||||||||:||||||.|:
Zfish    71 LCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLQHKNVIQLVDVLYNEEKQKMYMVMEYCVCGM 135

  Fly   260 QEMIDYQPDKRMPLFQAHGYFKQLVDGLEYLHSCRVIHKDIKPGNLLLSLDQTLKISDFGVAEQL 324
            |||:|..|.||.|:|||||||.||:||||||||..::|||||||||||:.|..|||||.||||.|
Zfish   136 QEMLDSVPGKRFPVFQAHGYFCQLLDGLEYLHSQGIVHKDIKPGNLLLTTDGALKISDLGVAEAL 200

  Fly   325 DLFAPDDTCTTGQGSPAFQPPEIANGHETFAGFKVDIWSSGVTLYNLATGQYPFEGDNIYRLLEN 389
            ..||.||||.|.||||||||||||||.:||:||||||||:||||||:.|..|||||||||:|.||
Zfish   201 HPFAKDDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTSLYPFEGDNIYKLFEN 265

  Fly   390 IGRGQWEAPAWLYEMDADFANLILGMLQADPSKRLSLQEIRHDTWFRSAPVKTGPPIPIPPL--K 452
            ||:|.:..|.   |.....::|:.|||:.||.||.|:|.||...|.|.....:..|:||||.  .
Zfish   266 IGKGDYSIPE---ECGPLLSDLLRGMLEYDPVKRFSIQRIRQHNWVRKKHASSERPVPIPPSAET 327

  Fly   453 GDKYRNSTVIPYLEAYH-YGTQ--EEDVYFTEHDV--NQELARQAAAAASEIRAKQSAAALAACH 512
            .|::|:.||:||||..| ||.:  ||:::..|.|:  .|:.......|..|...::.|
Zfish   328 RDRWRSMTVVPYLEDLHGYGDEEDEEELFDGEDDIIYTQDFTVPGQVAEDEEEDEECA------- 385

  Fly   513 TYEPPSTSAAAASNSLGNGSREEAPVKKK-----GSALKRRAKKLTSCISVRKLSHCR 565
                |..:.|.|.....||: |.|.:|.|     .|:.....|.|::...:||||.|:
Zfish   386 ----PERTCAVAKAVCVNGT-ESAALKPKCERRSSSSSNPSRKGLSAASKIRKLSTCK 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	178/262 (68%)
Lkb1	NP_001163606.1	STKc_LKB1	178..435	CDD:271021	174/256 (68%)
stk11	NP_001017839.1	S_TKc	48..308	CDD:214567	178/262 (68%)
stk11	NP_001017839.1	STKc_LKB1	54..308	CDD:271021	174/256 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595209
Domainoid	1	1.000	366	1.000	Domainoid score	I876
eggNOG	1	0.900	-	-		E33208_3BA8D
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	440	1.000	Inparanoid score	I1637
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D517525at33208
OrthoFinder	1	1.000	-	-		FOG0006218
OrthoInspector	1	1.000	-	-		oto41699
orthoMCL	1	0.900	-	-		OOG6_104622
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2709
SonicParanoid	1	1.000	-	-		X5157
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.690