DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkb1 and stk11

DIOPT Version :9

Sequence 1:	NP_001163606.1	Gene:	Lkb1 / 41673	FlyBaseID:	FBgn0038167	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_001016533.1	Gene:	stk11 / 549287	XenbaseID:	XB-GENE-955279	Length:	432	Species:	Xenopus tropicalis

Alignment Length:	454	Identity:	236/454 - (51%)
Similarity:	308/454 - (67%)	Gaps:	36/454 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 LDDQPHPQVTWLDDDEIETLDRVTLDMG-NMFFNRVDSQDIIYQQKKKSIKMVGKYIMGDVLGEG 181
            :|:....::.:|.|          |.:| :.|.:|:||.::|||.::|..|:||||:|||:||||
Frog     7 MDEGGSQEIGFLGD----------LSVGMDTFIHRIDSTEVIYQPRRKRAKLVGKYLMGDLLGEG 61

  Fly   182 SYGKVKEAMNSENLCRLAVKILTKRKLRRIPNGEQNVTREIALLKQLKHRHVVELVDVLYNEEKQ 246
            |||||||.::|:.|||.|||||.|:|||||||||.||.:||.||::|:||:|::|||||||||||
Frog    62 SYGKVKEMLDSDTLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHRNVIQLVDVLYNEEKQ 126

  Fly   247 KMYLVMEYCVGGLQEMIDYQPDKRMPLFQAHGYFKQLVDGLEYLHSCRVIHKDIKPGNLLLSLDQ 311
            |||:||||||.|:|||:|...:|..|:|||||||.||:||||||||..::|||||||||||:.|.
Frog   127 KMYMVMEYCVCGMQEMLDSVQEKHFPVFQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTDG 191

  Fly   312 TLKISDFGVAEQLDLFAPDDTCTTGQGSPAFQPPEIANGHETFAGFKVDIWSSGVTLYNLATGQY 376
            ||||||.||||.|..||..|||.|.||||||||||||||.:||:||||||||:||||||:.||.|
Frog   192 TLKISDLGVAEALHPFAEGDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLY 256

  Fly   377 PFEGDNIYRLLENIGRGQWEAPAWLYEMDADFANLILGMLQADPSKRLSLQEIRHDTWFRSAPVK 441
            ||||||||:|.||||:|.:..|.   |.....::|:.|||:.||:||.|:|:||...|||.....
Frog   257 PFEGDNIYKLFENIGKGDYSIPE---ECGPLLSDLLRGMLEYDPAKRFSIQQIRQHNWFRKKHPH 318

  Fly   442 TGPPIPIPPL--KGDKYRNSTVIPYLEAYHYGTQEEDVYFTEHDV--NQELARQAAAAASEIRAK 502
            ..|.:||||.  ..|::|:.||:||||..|..::|||:...|.|:  .|:.......|..:..|:
Frog   319 MDPIVPIPPSPETKDRWRSLTVVPYLEDLHGYSEEEDLCDLEDDIIYTQDFTVPGQVAEDDYFAQ 383

  Fly   503 QSAAALAACHTYEPPSTSAAAASNSL-GNGSREEAPVKKKGSALKRRAKKLTSCISVRKLSHCR 565
                            |.:.|.|..| .||:..:...:::.|:..:| |..|:...|||||.|:
Frog   384 ----------------TQSTAPSKQLCMNGTENQLKTERRVSSSSQR-KASTAGSKVRKLSACK 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	178/262 (68%)
Lkb1	NP_001163606.1	STKc_LKB1	178..435	CDD:271021	174/256 (68%)
stk11	NP_001016533.1	STKc_LKB1	58..312	CDD:271021	174/256 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	349	1.000	Domainoid score	I1020
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	426	1.000	Inparanoid score	I1725
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D517525at33208
OrthoFinder	1	1.000	-	-		FOG0006218
OrthoInspector	1	1.000	-	-		oto103896
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5157
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.970